TDP1 and TOP1 Modulation in Olaparib-Resistant Cancer Determines the Efficacy of Subsequent Chemotherapy (Q89578157)

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6 April 2020

title

TDP1 and TOP1 Modulation in Olaparib-Resistant Cancer Determines the Efficacy of Subsequent Chemotherapy (English)

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6 April 2020

1

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6 April 2020

Kyung Hun Lee

7

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6 April 2020

Yung-Jue Bang

12

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3

Seock-Ah Im

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6 April 2020

author name string

Ahrum Min

2

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6 April 2020

Hyemin Jang

4

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6 April 2020

Yu Jin Kim

5

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Hee-Jun Kim

6

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6 April 2020

Tae-Yong Kim

8

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6 April 2020

Keun Wook Lee

9

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Do-Youn Oh

10

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Jee-Hyun Kim

11

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publication date

3 February 2020

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6 April 2020

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volume

12

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issue

2

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Creative Commons Attribution 4.0 International

6 April 2020

copyright license

start time

3 February 2020

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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CPT-11 in human colon-cancer cell lines and xenografts: characterization of cellular sensitivity determinants

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12 December 2020

Association of XRCC1 and tyrosyl DNA phosphodiesterase (Tdp1) for the repair of topoisomerase I-mediated DNA lesions

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Cytotoxicity and DNA Topoisomerase Inhibitory Activity of Benz[f]indole-4,9-dione Analogs

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TDP1 overexpression in human cells counteracts DNA damage mediated by topoisomerases I and II

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Olaparib Maintenance Therapy in Platinum-Sensitive Relapsed Ovarian Cancer

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Germline RAD51C mutations in ovarian cancer susceptibility

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Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors

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RAD51C-deficient cancer cells are highly sensitive to the PARP inhibitor olaparib

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Differing effects of adjuvant chemotherapy according to BRCA1 nuclear expression in gastric cancer

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Efficacy of chemotherapy in BRCA1/2 mutation carrier ovarian cancer in the setting of PARP inhibitor resistance: a multi-institutional study

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The use of Olaparib (AZD2281) potentiates SN-38 cytotoxicity in colon cancer cells by indirect inhibition of Rad51-mediated repair of DNA double-strand breaks.

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Clinical and cellular roles for TDP1 and TOP1 in modulating colorectal cancer response to irinotecan

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A Dominant Mutation in Human RAD51 Reveals Its Function in DNA Interstrand Crosslink Repair Independent of Homologous Recombination

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Randomized, Double-Blind Phase II Trial With Prospective Classification by ATM Protein Level to Evaluate the Efficacy and Tolerability of Olaparib Plus Paclitaxel in Patients With Recurrent or Metastatic Gastric Cancer

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Olaparib in combination with paclitaxel in patients with advanced gastric cancer who have progressed following first-line therapy (GOLD): a double-blind, randomised, placebo-controlled, phase 3 trial

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Pan-Pim Kinase Inhibitor AZD1208 Suppresses Tumor Growth and Synergistically Interacts with Akt Inhibition in Gastric Cancer Cells.

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Targeting Topoisomerase I in the Era of Precision Medicine

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12 December 2020

Identifiers

DOI

10.3390/CANCERS12020334

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6 April 2020

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6 April 2020

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