Sterol 14α-Demethylase Structure-Based Design of VNI (( R)- N-(1-(2,4-Dichlorophenyl)-2-(1 H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallogr (Q89076660)

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scientific article published on 25 June 2018

Language	Label	Description	Also known as
English	Sterol 14α-Demethylase Structure-Based Design of VNI (( R)- N-(1-(2,4-Dichlorophenyl)-2-(1 H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallogr	scientific article published on 25 June 2018

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scholarly article

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31 March 2020

Sterol 14α-Demethylase Structure-Based Design of VNI (( R)- N-(1-(2,4-Dichlorophenyl)-2-(1 H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic Analysis (English)

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31 March 2020

Craig W. Lindsley

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F. Peter Guengerich

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31 March 2020

Galina I. Lepesheva

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31 March 2020

Zdzislaw Wawrzak

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Zdzislaw Wawrzak

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Maurizio Botta

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31 March 2020

author name string

Laura Friggeri

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31 March 2020

Tatiana Y Hargrove

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31 March 2020

Anna L Blobaum

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31 March 2020

Girish Rachakonda

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Fernando Villalta

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W David Nes

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publication date

25 June 2018

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31 March 2020

Journal of Medicinal Chemistry

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5679-5691

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31 March 2020

13

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31 March 2020

Interaction of azole antifungal agents with cytochrome P-45014DM purified from Saccharomyces cerevisiae microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/29894182

12 December 2020

based on heuristic

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Spectral studies of drug interaction with hepatic microsomal cytochrome.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29894182

12 December 2020

based on heuristic

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In vitro and in vivo effects of the antimycotic drug ketoconazole on sterol synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29894182

12 December 2020

based on heuristic

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Yeast cytochrome P-450 catalyzing lanosterol 14 alpha-demethylation. II. Lanosterol metabolism by purified P-450(14)DM and by intact microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/29894182

12 December 2020

based on heuristic

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A graphical user interface to the CCP4 program suite

1 reference

https://pubmed.ncbi.nlm.nih.gov/29894182

12 December 2020

based on heuristic

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Sterol 14alpha-demethylase as a potential target for antitrypanosomal therapy: enzyme inhibition and parasite cell growth

1 reference

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12 December 2020

based on heuristic

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Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections

1 reference

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12 December 2020

based on heuristic

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Therapy for fungal diseases: opportunities and priorities

1 reference

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12 December 2020

based on heuristic

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Features and development of Coot

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12 December 2020

based on heuristic

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Structural basis for conservation in the CYP51 family

1 reference

https://pubmed.ncbi.nlm.nih.gov/29894182

12 December 2020

based on heuristic

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1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sterol 14alpha-demethylase (CYP51) as a therapeutic target for human trypanosomiasis and leishmaniasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29894182

12 December 2020

based on heuristic

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Hidden killers: human fungal infections

1 reference

https://pubmed.ncbi.nlm.nih.gov/29894182

12 December 2020

based on heuristic

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VNI cures acute and chronic experimental Chagas disease

1 reference

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12 December 2020

based on heuristic

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Antitrypanosomal Lead Discovery: Identification of a Ligand-Efficient Inhibitor of Trypanosoma cruzi CYP51 and Parasite Growth

1 reference

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12 December 2020

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Complexes of Trypanosoma cruzi Sterol 14 -Demethylase (CYP51) with Two Pyridine-based Drug Candidates for Chagas Disease: STRUCTURAL BASIS FOR PATHOGEN SELECTIVITY

1 reference

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12 December 2020

based on heuristic

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New Promising Compounds with in Vitro Nanomolar Activity against Trypanosoma cruzi

1 reference

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12 December 2020

based on heuristic

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Structural Basis for Rational Design of Inhibitors Targeting Trypanosoma cruzi Sterol 14α-Demethylase: Two Regions of the Enzyme Molecule Potentiate Its Inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/29894182

12 December 2020

based on heuristic

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Infectious Disease. How to bolster the antifungal pipeline

1 reference

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12 December 2020

based on heuristic

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VFV as a New Effective CYP51 Structure-Derived Drug Candidate for Chagas Disease and Visceral Leishmaniasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29894182

12 December 2020

based on heuristic

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Structure-Functional Characterization of Cytochrome P450 Sterol 14α-Demethylase (CYP51B) from Aspergillus fumigatus and Molecular Basis for the Development of Antifungal Drugs

1 reference

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12 December 2020

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Invasive Candidiasis

1 reference

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12 December 2020

based on heuristic

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Ligand tunnels in T. brucei and human CYP51: Insights for parasite-specific drug design.

1 reference

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12 December 2020

based on heuristic

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Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America

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12 December 2020

based on heuristic

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Isavuconazole versus voriconazole for primary treatment of invasive mould disease caused by Aspergillus and other filamentous fungi (SECURE): a phase 3, randomised-controlled, non-inferiority trial

1 reference

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12 December 2020

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Human sterol 14α-demethylase as a target for anticancer chemotherapy: towards structure-aided drug design

1 reference

https://pubmed.ncbi.nlm.nih.gov/29894182

12 December 2020

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Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis

1 reference

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12 December 2020

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Crystal Structure of the New Investigational Drug Candidate VT-1598 in Complex with Aspergillus fumigatus Sterol 14α-Demethylase Provides Insights into Its Broad-Spectrum Antifungal Activity

1 reference

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Global and Multi-National Prevalence of Fungal Diseases-Estimate Precision.

1 reference

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12 December 2020

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Posaconazole MIC distributions for Aspergillus fumigatus SC by four methods: Impact of Cyp51A mutations on estimation of epidemiological cutoff values (ECVs/ECOFFs).

1 reference

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CYP51 as drug targets for fungi and protozoan parasites: past, present and future.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29894182

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Identifiers

10.1021/ACS.JMEDCHEM.8B00641

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31 March 2020

1 reference

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31 March 2020

1 reference

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31 March 2020

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