A placebo-controlled, multiple ascending dose study to evaluate the safety, pharmacokinetics and pharmacodynamics of avagacestat (BMS-708163) in healthy young and elderly subjects (Q87389000)

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scientific article published on 01 October 2012

Language	Label	Description	Also known as
English	A placebo-controlled, multiple ascending dose study to evaluate the safety, pharmacokinetics and pharmacodynamics of avagacestat (BMS-708163) in healthy young and elderly subjects	scientific article published on 01 October 2012

Statements

scholarly article

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9 March 2020

A placebo-controlled, multiple ascending dose study to evaluate the safety, pharmacokinetics and pharmacodynamics of avagacestat (BMS-708163) in healthy young and elderly subjects (English)

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9 March 2020

pharmacokinetics

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pharmacodynamics

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author name string

Randy Dockens

1

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9 March 2020

Jun-Sheng Wang

2

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9 March 2020

Lorna Castaneda

3

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9 March 2020

Oleksandr Sverdlov

4

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9 March 2020

Shu-Pang Huang

5

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9 March 2020

Randy Slemmon

6

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9 March 2020

Huidong Gu

7

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9 March 2020

Oi Wong

8

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9 March 2020

Hewei Li

9

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9 March 2020

Robert M Berman

10

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9 March 2020

Christina Smith

11

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9 March 2020

Charles F Albright

12

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9 March 2020

Gary Tong

13

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publication date

1 October 2012

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9 March 2020

Clinical Pharmacokinetics

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9 March 2020

51

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10

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681-693

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9 March 2020

Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease

1 reference

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The amyloid hypothesis for Alzheimer's disease: a critical reappraisal

1 reference

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12 December 2020

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A beta oligomers - a decade of discovery

1 reference

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Effects of a gamma-secretase inhibitor in a randomized study of patients with Alzheimer disease

1 reference

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12 December 2020

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

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12 December 2020

based on heuristic

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2010 Alzheimer's disease facts and figures

1 reference

https://pubmed.ncbi.nlm.nih.gov/23018531

12 December 2020

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The amyloid-beta rise and gamma-secretase inhibitor potency depend on the level of substrate expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/23018531

12 December 2020

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Development and validation of sensitive and selective LC-MS/MS methods for the determination of BMS-708163, a gamma-secretase inhibitor, in plasma and cerebrospinal fluid using deprotonated or formate adduct ions as precursor ions

1 reference

https://pubmed.ncbi.nlm.nih.gov/23018531

12 December 2020

based on heuristic

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Concentration-dependent modulation of amyloid-beta in vivo and in vitro using the gamma-secretase inhibitor, LY-450139.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23018531

12 December 2020

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Identification of Notch target genes in uncommitted T-cell progenitors: No direct induction of a T-cell specific gene program

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Prediction of survival in diffuse large-B-cell lymphoma based on the expression of six genes

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Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23018531

12 December 2020

based on heuristic

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Reduced levels of amyloid-beta-binding proteins in cerebrospinal fluid from Alzheimer's disease patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23018531

12 December 2020

based on heuristic

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Safety, tolerability, and effects on plasma and cerebrospinal fluid amyloid-beta after inhibition of gamma-secretase

1 reference

https://pubmed.ncbi.nlm.nih.gov/23018531

12 December 2020

based on heuristic

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gamma-Secretase as a therapeutic target in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23018531

12 December 2020

based on heuristic

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Multicenter, randomized, double-blind, placebo-controlled, single-ascending dose study of the oral γ-secretase inhibitor BMS-708163 (Avagacestat): tolerability profile, pharmacokinetic parameters, and pharmacodynamic markers

1 reference

https://pubmed.ncbi.nlm.nih.gov/23018531

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The secretases: enzymes with therapeutic potential in Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23018531

12 December 2020

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General derivation of the equation for time to reach a certain fraction of steady state.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23018531

12 December 2020

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Novel research horizons for presenilins and γ-secretases in cell biology and disease

1 reference

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The application of statistical moment theory to the evaluation of in vivo dissolution time and absorption time.

1 reference

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Rolling in the clover: trefoil factor family (TFF)-domain peptides, cell migration and cancer.

1 reference

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12 December 2020

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The role of cerebral amyloid beta accumulation in common forms of Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23018531

12 December 2020

based on heuristic

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Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/23018531

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Safety, tolerability, and changes in amyloid beta concentrations after administration of a gamma-secretase inhibitor in volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/23018531

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stool form scale as a useful guide to intestinal transit time

1 reference

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12 December 2020

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Stabilization of mRNA expression in whole blood samples.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23018531

12 December 2020

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Identifiers

10.1007/S40262-012-0005-X

1 reference

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9 March 2020

1 reference

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9 March 2020

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