Pharmacological inhibition of the chemokine C-C motif chemokine ligand 2 (monocyte chemoattractant protein 1) accelerates liver fibrosis regression by suppressing Ly-6C(+) macrophage infiltration in mice (Q87203689)

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scientific article published on 30 January 2014

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English	Pharmacological inhibition of the chemokine C-C motif chemokine ligand 2 (monocyte chemoattractant protein 1) accelerates liver fibrosis regression by suppressing Ly-6C(+) macrophage infiltration in mice	scientific article published on 30 January 2014

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scholarly article

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6 March 2020

Pharmacological inhibition of the chemokine C-C motif chemokine ligand 2 (monocyte chemoattractant protein 1) accelerates liver fibrosis regression by suppressing Ly-6C(+) macrophage infiltration in mice (English)

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6 March 2020

author name string

Christer Baeck

1

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Xiao Wei

2

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Matthias Bartneck

3

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Viktor Fech

4

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Felix Heymann

5

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Nikolaus Gassler

6

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Kanishka Hittatiya

7

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6 March 2020

Dirk Eulberg

8

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Tom Luedde

9

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Christian Trautwein

10

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Frank Tacke

11

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publication date

30 January 2014

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59

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3

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1060-1072

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6 March 2020

Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis

1 reference

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Monocytes and macrophages as cellular targets in liver fibrosis

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Hepatic recruitment of the inflammatory Gr1+monocyte subset upon liver injury promotes hepatic fibrosis

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Functional contribution of elevated circulating and hepatic non-classical CD14CD16 monocytes to inflammation and human liver fibrosis

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Monocyte subsets in human liver disease show distinct phenotypic and functional characteristics

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Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair

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Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosis

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Elastin accumulation is regulated at the level of degradation by macrophage metalloelastase (MMP-12) during experimental liver fibrosis

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CCR2 promotes hepatic fibrosis in mice

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Monocyte chemoattractant protein-1 (MCP-1): an overview

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Lack of CC chemokine ligand 2 differentially affects inflammation and fibrosis according to the genetic background in a murine model of steatohepatitis

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Dual role of CCR2 in the constitution and the resolution of liver fibrosis in mice

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Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury.

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Hepatic macrophage migration and differentiation critical for liver fibrosis is mediated by the chemokine receptor C-C motif chemokine receptor 8 in mice.

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Late onset of Ccl2 blockade with the Spiegelmer mNOX-E36-3'PEG prevents glomerulosclerosis and improves glomerular filtration rate in db/db mice.

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Langerhans cells arise from monocytes in vivo

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Immature monocytes acquire antigens from other cells in the bone marrow and present them to T cells after maturing in the periphery

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The fractalkine receptor CX₃CR1 protects against liver fibrosis by controlling differentiation and survival of infiltrating hepatic monocytes

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Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques

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Functional role of monocytes and macrophages for the inflammatory response in acute liver injury

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Modification of chemokine pathways and immune cell infiltration as a novel therapeutic approach in liver inflammation and fibrosis

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A significant proportion of myofibroblasts are of bone marrow origin in human liver fibrosis.

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Critical review of clinical trials of bone marrow stem cells in liver disease.

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The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C- monocytes

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Chronic inflammation, immune escape, and oncogenesis in the liver: a unique neighborhood for novel intersections

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Comparison of gene expression profiles between human and mouse monocyte subsets

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Functional role of intrahepatic monocyte subsets for the progression of liver inflammation and liver fibrosis in vivo

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Identifiers

10.1002/HEP.26783

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6 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24481979%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

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