γ-H2AX foci formation as a pharmacodynamic marker of DNA damage produced by DNA cross-linking agents: results from 2 phase I clinical trials of SJG-136 (SG2000) (Q85727980)

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scientific article published on 18 December 2012

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English	γ-H2AX foci formation as a pharmacodynamic marker of DNA damage produced by DNA cross-linking agents: results from 2 phase I clinical trials of SJG-136 (SG2000)	scientific article published on 18 December 2012

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scholarly article

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20 February 2020

γ-H2AX foci formation as a pharmacodynamic marker of DNA damage produced by DNA cross-linking agents: results from 2 phase I clinical trials of SJG-136 (SG2000) (English)

1 reference

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20 February 2020

phase I clinical trial

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based on heuristic

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pharmacodynamics

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6

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20 February 2020

author name string

Jenny Wu

1

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20 February 2020

Peter H Clingen

2

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20 February 2020

Victoria J Spanswick

3

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20 February 2020

Maria Mellinas-Gomez

4

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20 February 2020

Tim Meyer

5

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20 February 2020

Duncan Jodrell

7

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20 February 2020

Daniel Hochhauser

8

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20 February 2020

John A Hartley

9

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20 February 2020

publication date

18 December 2012

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20 February 2020

Clinical Cancer Research

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20 February 2020

19

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20 February 2020

721-730

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20 February 2020

3

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20 February 2020

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/23251007

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defining the roles of nucleotide excision repair and recombination in the repair of DNA interstrand cross-links in mammalian cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23251007

12 December 2020

based on heuristic

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Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23251007

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23251007

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses

1 reference

https://pubmed.ncbi.nlm.nih.gov/23251007

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of histone H2AX as a measure of radiosensitivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23251007

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessment of histone H2AX phosphorylation induced by DNA topoisomerase I and II inhibitors topotecan and mitoxantrone and by the DNA cross-linking agent cisplatin

1 reference

https://pubmed.ncbi.nlm.nih.gov/23251007

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The structure-specific endonuclease Ercc1-Xpf is required to resolve DNA interstrand cross-link-induced double-strand breaks

1 reference

https://pubmed.ncbi.nlm.nih.gov/23251007

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 1: cellular pharmacology, in vitro and initial in vivo antitumor activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23251007

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 2: efficacy evaluations

1 reference

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12 December 2020

based on heuristic

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Radiation sensitivity, H2AX phosphorylation, and kinetics of repair of DNA strand breaks in irradiated cervical cancer cell lines

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequence-selective interaction of the minor-groove interstrand cross-linking agent SJG-136 with naked and cellular DNA: footprinting and enzyme inhibition studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/23251007

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I trial combining gemcitabine and treosulfan in advanced cutaneous and uveal melanoma patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/23251007

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The XPF-ERCC1 endonuclease and homologous recombination contribute to the repair of minor groove DNA interstrand crosslinks in mammalian cells produced by the pyrrolo[2,1-c][1,4]benzodiazepine dimer SJG-136

1 reference

https://pubmed.ncbi.nlm.nih.gov/23251007

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

gamma-H2AX formation in response to interstrand crosslinks requires XPF in human cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23251007

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Time-dependent cytotoxicity induced by SJG-136 (NSC 694501): influence of the rate of interstrand cross-link formation on DNA damage signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/23251007

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylated histone H2AX in relation to cell survival in tumor cells and xenografts exposed to single and fractionated doses of X-rays

1 reference

https://pubmed.ncbi.nlm.nih.gov/23251007

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GammaH2AX and its role in DNA double-strand break repair

1 reference

https://pubmed.ncbi.nlm.nih.gov/23251007

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A phase I study of single administration of antibody-directed enzyme prodrug therapy with the recombinant anti-carcinoembryonic antigen antibody-enzyme fusion protein MFECP1 and a bis-iodo phenol mustard prodrug.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23251007

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GammaH2AX in cancer cells: a potential biomarker for cancer diagnostics, prediction and recurrence

1 reference

https://pubmed.ncbi.nlm.nih.gov/23251007

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A phase 1 clinical-laboratory study of clofarabine followed by cyclophosphamide for adults with refractory acute leukemias

1 reference

https://pubmed.ncbi.nlm.nih.gov/23251007

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histone H2AX phosphorylation as a molecular pharmacological marker for DNA interstrand crosslink cancer chemotherapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23251007

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Active oral regimen for elderly adults with newly diagnosed acute myelogenous leukemia: a preclinical and phase 1 trial of the farnesyltransferase inhibitor tipifarnib (R115777, Zarnestra) combined with etoposide

1 reference

https://pubmed.ncbi.nlm.nih.gov/23251007

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I study of sequence-selective minor groove DNA binding agent SJG-136 in patients with advanced solid tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/23251007

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

gammaH2AX expression in tumors exposed to cisplatin and fractionated irradiation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23251007

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A phase I trial of SJG-136 (NSC#694501) in advanced solid tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/23251007

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

H2AX: functional roles and potential applications

1 reference

https://pubmed.ncbi.nlm.nih.gov/23251007

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pyrrolobenzodiazepine dimer SJG-136 forms sequence-dependent intrastrand DNA cross-links and monoalkylated adducts in addition to interstrand cross-links.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23251007

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Measurement of DNA interstrand crosslinking in individual cells using the Single Cell Gel Electrophoresis (Comet) assay

1 reference

https://pubmed.ncbi.nlm.nih.gov/23251007

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monitoring drug-induced gammaH2AX as a pharmacodynamic biomarker in individual circulating tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23251007

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quinone oxidoreductase-2-mediated prodrug cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23251007

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of carboplatin-induced DNA interstrand cross-link repair by gemcitabine in patients receiving these drugs for platinum-resistant ovarian cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23251007

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histone gammaH2AX and poly(ADP-ribose) as clinical pharmacodynamic biomarkers

1 reference

https://pubmed.ncbi.nlm.nih.gov/23251007

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of a validated immunofluorescence assay for γH2AX as a pharmacodynamic marker of topoisomerase I inhibitor activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23251007

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I pharmacokinetic and pharmacodynamic study of SJG-136, a novel DNA sequence selective minor groove cross-linking agent, in advanced solid tumors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23251007

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the "comet" assay

1 reference

https://pubmed.ncbi.nlm.nih.gov/23251007

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/1078-0432.CCR-12-2529

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23251007%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23251007%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23251007%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

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