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Action of SN 28049, a new DNA binding topoisomerase II-directed antitumour drug: comparison with doxorubicin and etoposide (Q84453578)

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scientific article published on 22 June 2010

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English	Action of SN 28049, a new DNA binding topoisomerase II-directed antitumour drug: comparison with doxorubicin and etoposide	scientific article published on 22 June 2010

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6 February 2020

Action of SN 28049, a new DNA binding topoisomerase II-directed antitumour drug: comparison with doxorubicin and etoposide (English)

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6 February 2020

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Catherine Drummond

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6 February 2020

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Graeme J Finlay

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6 February 2020

Laura Broome

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6 February 2020

Elaine S Marshall

4

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6 February 2020

Emma Richardson

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6 February 2020

Bruce C Baguley

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6 February 2020

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22 June 2010

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6 February 2020

language of work or name

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Investigational New Drugs

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6 February 2020

29

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6 February 2020

5

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6 February 2020

1102-1110

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6 February 2020

The experimental antitumour properties of three congeners of the acridylmethanesulphonanilide (AMSA) series

1 reference

https://pubmed.ncbi.nlm.nih.gov/20567995

12 December 2020

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Synthesis, antitumor activity, and DNA binding properties of a new derivative of amsacrine, N-5-dimethyl-9-[(2-methoxy-4-methylsulfonylamino) phenylamino]-4-acridinecarboxamide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20567995

12 December 2020

based on heuristic

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Phase I study of the cytotoxic agent N-[2-(dimethylamino)ethyl]acridine-4-carboxamide

1 reference

https://pubmed.ncbi.nlm.nih.gov/20567995

12 December 2020

based on heuristic

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p53 localization at centrosomes during mitosis and postmitotic checkpoint are ATM-dependent and require serine 15 phosphorylation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20567995

12 December 2020

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Properties of antitumor anthracyclines and new developments in their application: Cain memorial award lecture

1 reference

https://pubmed.ncbi.nlm.nih.gov/20567995

12 December 2020

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Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks

1 reference

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12 December 2020

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Radiation-induced cell cycle delays and p53 status of early passage melanoma cell lines

1 reference

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12 December 2020

based on heuristic

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Dual role of topoisomerase II in centromere resolution and aurora B activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20567995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Experimental solid tumour activity of N-[2-(dimethylamino)ethyl]-acridine-4-carboxamide

1 reference

https://pubmed.ncbi.nlm.nih.gov/20567995

12 December 2020

based on heuristic

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Topoisomerase IIalpha controls the decatenation checkpoint

1 reference

https://pubmed.ncbi.nlm.nih.gov/20567995

12 December 2020

based on heuristic

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Mechanism of G1-like arrest by low concentrations of paclitaxel: next cell cycle p53-dependent arrest with sub G1 DNA content mediated by prolonged mitosis

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/20567995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics and distribution of SN 28049, a novel DNA binding anticancer agent, in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20567995

12 December 2020

based on heuristic

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Synthesis and antitumor properties of N-[2-(dimethylamino)ethyl]carboxamide derivatives of fused tetracyclic quinolines and quinoxalines: a new class of putative topoisomerase inhibitors

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139

1 reference

https://pubmed.ncbi.nlm.nih.gov/20567995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crosstalk of the mitotic spindle assembly checkpoint with p53 to prevent polyploidy

1 reference

https://pubmed.ncbi.nlm.nih.gov/20567995

12 December 2020

based on heuristic

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The role of topoisomerases and RNA transcription in the action of the antitumour benzonaphthyridine derivative SN 28049.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20567995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

To cell cycle, swing the APC/C.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20567995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple patterns of resistance of human leukemia cell sublines to amsacrine analogues

1 reference

https://pubmed.ncbi.nlm.nih.gov/20567995

12 December 2020

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Synthesis and cytotoxic activity of carboxamide derivatives of benzo[b][1,6]naphthyridin-(5H)ones.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20567995

12 December 2020

based on heuristic

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Phase II study of the amsacrine analogue CI-921 (NSC 343499) in non-small cell lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/20567995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Topoisomerase II gene mutations in tumors and tumor cell lines with microsatellite instability

1 reference

https://pubmed.ncbi.nlm.nih.gov/20567995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the p53-Dependent Postmitotic Checkpoint following Spindle Disruption

1 reference

https://pubmed.ncbi.nlm.nih.gov/20567995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I and II trial of 4'-(9-acridinylamino)methanesulfon-m-anisidide in patients with acute leukemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20567995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcriptional repression of the anti-apoptotic survivin gene by wild type p53.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20567995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and cytotoxic activity of carboxamide derivatives of benzo[b][1,6]naphthyridines

1 reference

https://pubmed.ncbi.nlm.nih.gov/20567995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chromosome alignment and segregation regulated by ubiquitination of survivin

1 reference

https://pubmed.ncbi.nlm.nih.gov/20567995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytometry of ATM activation and histone H2AX phosphorylation to estimate extent of DNA damage induced by exogenous agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/20567995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of cytotoxicity of N-[2-(dimethylamino)ethyl] acridine-4-carboxamide and of its 7-chloro derivative: the roles of topoisomerases I and II.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20567995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathways of apoptotic and non-apoptotic death in tumour cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20567995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radiosensitivity of new and established human melanoma cell lines: comparison of [3H]thymidine incorporation and soft agar clonogenic assays

1 reference

https://pubmed.ncbi.nlm.nih.gov/20567995

12 December 2020

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The chemical and biological route from podophyllotoxin glucoside to etoposide: ninth Cain memorial Award lecture

1 reference

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12 December 2020

based on heuristic

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