Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass (Q83207600)

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20 January 2020

title

Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass (English)

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12

Hitoshi Okamura

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author name string

Naoko Hashimoto

1

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Yoshiaki Kido

2

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Tohru Uchida

3

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Shun-ichiro Asahara

4

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Yutaka Shigeyama

5

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Tomokazu Matsuda

6

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Akihiko Takeda

7

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Daisuke Tsuchihashi

8

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Akihiko Nishizawa

9

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Wataru Ogawa

10

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Yoshito Fujimoto

11

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Karen C Arden

13

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Tetsuo Noda

15

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Masato Kasuga

16

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publication date

23 April 2006

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volume

38

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page(s)

589-593

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issue

5

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https://scigraph.springernature.com/pub.10.1038/ng1774

20 January 2020

exact match

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cites work

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

1 reference

7 January 2021

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

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7 January 2021

Disruption of IRS-2 causes type 2 diabetes in mice

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7 January 2021

Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

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7 January 2021

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

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7 January 2021

Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta

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7 January 2021

Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice.

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7 January 2021

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

1 reference

7 January 2021

Essential role of PDK1 in regulating cell size and development in mice

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7 January 2021

FoxOs at the crossroads of cellular metabolism, differentiation, and transformation

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7 January 2021

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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7 January 2021

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.

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7 January 2021

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth

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7 January 2021

Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice

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7 January 2021

Genetic control of cell size

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7 January 2021

Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K.

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7 January 2021

Role for Akt3/protein kinase Bgamma in attainment of normal brain size

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Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia

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7 January 2021

Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes

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7 January 2021

Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus

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7 January 2021

Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes

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7 January 2021

Role of hepatic STAT3 in brain-insulin action on hepatic glucose production.

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7 January 2021

Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1.

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7 January 2021

PKClambda regulates glucose-induced insulin secretion through modulation of gene expression in pancreatic beta cells

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7 January 2021

Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.

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7 January 2021

Light-induced resetting of a mammalian circadian clock is associated with rapid induction of the mPer1 transcript.

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Disruption of the WFS1 gene in mice causes progressive beta-cell loss and impaired stimulus-secretion coupling in insulin secretion

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7 January 2021

Identifiers

DOI

10.1038/NG1774

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20 January 2020

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