Scaffold-hopping cascade yields potent inhibitors of 5-lipoxygenase (Q81758946)

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11 January 2020

title

Scaffold-hopping cascade yields potent inhibitors of 5-lipoxygenase (English)

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11 January 2020

7

Gisbert Schneider

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11 January 2020

5

Petra Schneider

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11 January 2020

author name string

Bettina Hofmann

1

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11 January 2020

Lutz Franke

2

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11 January 2020

Ewgenij Proschak

3

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11 January 2020

Yusuf Tanrikulu

4

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11 January 2020

Dieter Steinhilber

6

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11 January 2020

publication date

1 October 2008

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11 January 2020

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11 January 2020

volume

3

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11 January 2020

issue

10

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11 January 2020

page(s)

1535-1538

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Prostaglandins and leukotrienes: advances in eicosanoid biology

11 January 2020

cites work

1 reference

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7 January 2021

5-Lipoxygenase and atherosclerosis

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7 January 2021

Development of 5-lipoxygenase inhibitors--lessons from cellular enzyme regulation

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Licofelone--a novel analgesic and anti-inflammatory agent

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Cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) selectivity of COX inhibitors

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7 January 2021

Locating biologically active compounds in medium-sized heterogeneous datasets by topological autocorrelation vectors: dopamine and benzodiazepine agonists.

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7 January 2021

Dual inhibitors of cyclooxygenase and 5-lipoxygenase. A new avenue in anti-inflammatory therapy?

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7 January 2021

Therapeutic options for 5-lipoxygenase inhibitors

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7 January 2021

COX-2/5-LOX dual acting anti-inflammatory drugs in cancer chemotherapy.

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7 January 2021

Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening

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7 January 2021

Identification and Classification of GPCR Ligands Using Self-Organizing Neural Networks

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7 January 2021

Impact of conformational flexibility on three-dimensional similarity searching using correlation vectors

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7 January 2021

Sequential induction of 5-lipoxygenase gene expression and activity in Mono Mac 6 cells by transforming growth factor beta and 1,25-dihydroxyvitamin D3

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7 January 2021

Cyclooxygenase-1/2 (COX-1/COX-2) and 5-lipoxygenase (5-LOX) inhibitors of the 6,7-diaryl-2,3-1H-dihydropyrrolizine type

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7 January 2021

Dual inhibition of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) as a new strategy to provide safer non-steroidal anti-inflammatory drugs

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7 January 2021

Chemical Similarity Searching

1 reference

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7 January 2021

Reoptimization of MDL keys for use in drug discovery

1 reference

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7 January 2021

Do structurally similar molecules have similar biological activity?

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800153

7 January 2021

Application of belief theory to similarity data fusion for use in analog searching and lead hopping

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800153

7 January 2021

Scaffold hopping by "fuzzy" pharmacophores and its application to RNA targets

1 reference

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7 January 2021

N-(5-substituted) thiophene-2-alkylsulfonamides as potent inhibitors of 5-lipoxygenase

1 reference

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7 January 2021

Synthesis and biological evaluation of 5-[[3,5-bis(1,1-dimethylethyl)- 4-hydroxyphenyl]methylene]oxazoles, -thiazoles, and -imidazoles: novel dual 5-lipoxygenase and cyclooxygenase inhibitors with antiinflammatory activity

1 reference

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7 January 2021

Computer-aided discovery of anti-inflammatory thiazolidinones with dual cyclooxygenase/lipoxygenase inhibition

1 reference

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7 January 2021

Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes

1 reference

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7 January 2021

Extraction and visualization of potential pharmacophore points using support vector machines: application to ligand-based virtual screening for COX-2 inhibitors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800153

7 January 2021

Identifiers

DOI

10.1002/CMDC.200800153

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18688907%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

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