Insulin-like growth factor-1 receptor (IGF-1R) expression does not predict for resistance to trastuzumab-based treatment in patients with Her-2/neu overexpressing metastatic breast cancer (Q81261780)

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scientific article published on 24 September 2005

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English	Insulin-like growth factor-1 receptor (IGF-1R) expression does not predict for resistance to trastuzumab-based treatment in patients with Her-2/neu overexpressing metastatic breast cancer	scientific article published on 24 September 2005

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scholarly article

1 reference

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7 January 2020

Insulin-like growth factor-1 receptor (IGF-1R) expression does not predict for resistance to trastuzumab-based treatment in patients with Her-2/neu overexpressing metastatic breast cancer (English)

1 reference

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7 January 2020

metastatic breast cancer

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author name string

Wolfgang J Köstler

1

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7 January 2020

Gernot Hudelist

2

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7 January 2020

Werner Rabitsch

3

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7 January 2020

Klaus Czerwenka

4

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7 January 2020

Ruth Müller

5

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7 January 2020

Christian F Singer

6

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7 January 2020

Christoph C Zielinski

7

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7 January 2020

publication date

24 September 2005

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7 January 2020

Journal of Cancer Research and Clinical Oncology

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7 January 2020

132

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7 January 2020

9-18

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7 January 2020

1

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7 January 2020

https://scigraph.springernature.com/pub.10.1007/s00432-005-0038-8

0 references

Inhibition of in vivo breast cancer growth by antisense oligodeoxynucleotides to type I insulin-like growth factor receptor mRNA involves inactivation of ErbBs, PI-3K/Akt and p42/p44 MAPK signaling pathways but not modulation of progesterone recepto

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of ErbB-2 via a hierarchical interaction between ErbB-2 and type I insulin-like growth factor receptor in mammary tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical activity of trastuzumab and vinorelbine in women with HER2-overexpressing metastatic breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Weekly trastuzumab and paclitaxel therapy for metastatic breast cancer with analysis of efficacy by HER2 immunophenotype and gene amplification.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the insulin-like growth factor family in cancer development and progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical determination of estrogen and progesterone receptor content in human breast cancer. Computer-assisted image analysis (QIC score) vs. subjective grading (IRS)

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor 1 receptors in human breast tumour: localisation and quantification by histo-autoradiographic analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt Is required for antibody-mediated effects on p27, cyclin D1, and antitumor action

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The IRS-1 signaling system

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of HER2/neu expression and trastuzumab in non-small cell lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The insulin-like growth factor 1 receptor is expressed by epithelial cells with proliferative potential in human epidermis and skin appendages: correlation of increased expression with epidermal hyperplasia

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monitoring of serum Her-2/neu predicts response and progression-free survival to trastuzumab-based treatment in patients with metastatic breast cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AKT activation up-regulates insulin-like growth factor I receptor expression and promotes invasiveness of human pancreatic cancer cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trastuzumab and vinorelbine as first-line therapy for HER2-overexpressing metastatic breast cancer: multicenter phase II trial with clinical outcomes, analysis of serum tumor markers as predictive factors, and cardiac surveillance algorithm

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The expression of insulin-like growth factor-I receptor correlates with Fuhrman grading of renal cell carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sporadic amplification of the insulin-like growth factor 1 receptor gene in human breast tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor-I receptor signalling and acquired resistance to gefitinib (ZD1839; Iressa) in human breast and prostate cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitogen-activated protein kinase and phosphatidylinositol 3-kinase pathways are not sufficient for insulin-like growth factor I-induced mitogenesis and tumorigenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The efficacy of Herceptin therapies is influenced by the expression of other erbB receptors, their ligands and the activation of downstream signalling proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular and cellular aspects of the insulin-like growth factor I receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of the insulin-like growth factor I receptor in human colon carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The PIK3CA gene is mutated with high frequency in human breast cancers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Her-2/neu-triggered intracellular tyrosine kinase activation: in vivo relevance of ligand-independent activation mechanisms and impact upon the efficacy of trastuzumab-based treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PTEN inhibits cell proliferation and induces apoptosis by downregulating cell surface IGF-IR expression in prostate cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor I receptor activity in human medulloblastomas.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gemcitabine, paclitaxel, and trastuzumab in metastatic breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Co-targeting HER2/ErbB2 and insulin-like growth factor-1 receptors causes synergistic inhibition of growth in HER2-overexpressing breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin).

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt-dependent and -independent survival signaling pathways utilized by insulin-like growth factor I.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The localization of the insulin-like growth factor receptor 1 (IGFR-1) in benign and malignant breast tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the insulin-like growth factor-I receptor in primary breast cancer and lymph node metastases: correlations with estrogen receptors alpha and beta.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anticancer therapy targeting the erbB family of receptor tyrosine kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Breast Cancer Conference. Trastuzumab and capecitabine in the treatment of advanced breast cancer. Milano, 6-7 June 2002

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biology of HER2 and its importance in breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular mechanisms underlying IGF-I-induced attenuation of the growth-inhibitory activity of trastuzumab (Herceptin) on SKBR3 breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factors and neoplasia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C-terminal Src kinase associates with ligand-stimulated insulin-like growth factor-I receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of phosphorylated insulin-like growth factor-I receptor with the SH2 domains of phosphatidylinositol 3-kinase p85

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Southwest Oncology Group standard response criteria, endpoint definitions and toxicity criteria

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

erbB-2 overexpression in human mammary epithelial cells confers growth factor independence

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Down-regulation of insulin-like growth factor-I receptor and insulin receptor substrate-1 expression in advanced human breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of ErbB2 receptor inhibits IGF-I-induced Shc-MAPK signaling pathway in breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16184380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00432-005-0038-8

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16184380%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16184380%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

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