A SERCA2 pump with an increased Ca2+ affinity can lead to severe cardiac hypertrophy, stress intolerance and reduced life span (Q79824394)

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26 December 2019

title

A SERCA2 pump with an increased Ca2+ affinity can lead to severe cardiac hypertrophy, stress intolerance and reduced life span (English)

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26 December 2019

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1

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26 December 2019

Paul Herijgers

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7

Peter Carmeliet

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26 December 2019

author name string

Marc Tjwa

2

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26 December 2019

An Van Den Bergh

3

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26 December 2019

William E Louch

4

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26 December 2019

Monique Beullens

5

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26 December 2019

Leonard Dode

6

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26 December 2019

Evangelia Kranias

8

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Karin R Sipido

10

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Luc Raeymaekers

11

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Frank Wuytack

12

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publication date

30 June 2006

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Journal of Molecular and Cellular Cardiology

26 December 2019

published in

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volume

41

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issue

2

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page(s)

308-317

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SERCA pump level is a critical determinant of Ca(2+)homeostasis and cardiac contractility

26 December 2019

cites work

1 reference

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Modulating sarco(endo)plasmic reticulum Ca2+ ATPase 2 (SERCA2) activity: cell biological implications.

7 January 2021

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Phospholamban: a crucial regulator of cardiac contractility

7 January 2021

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Interactions between phospholamban and beta-adrenergic drive may lead to cardiomyopathy and early mortality

7 January 2021

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Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban

7 January 2021

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Targeting calcium cycling proteins in heart failure through gene transfer

7 January 2021

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Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy

7 January 2021

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Targeting phospholamban by gene transfer in human heart failure

7 January 2021

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Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery

7 January 2021

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Rescue of cardiomyocyte dysfunction by phospholamban ablation does not prevent ventricular failure in genetic hypertrophy

7 January 2021

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Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human

7 January 2021

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Replacement of the muscle-specific sarcoplasmic reticulum Ca(2+)-ATPase isoform SERCA2a by the nonmuscle SERCA2b homologue causes mild concentric hypertrophy and impairs contraction-relaxation of the heart

7 January 2021

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Dissection of the functional differences between sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) 1 and 2 isoforms and characterization of Darier disease (SERCA2) mutants by steady-state and transient kinetic analyses

7 January 2021

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Ca2+ transport ATPase isoforms SERCA2a and SERCA2b are targeted to the same sites in the murine heart.

7 January 2021

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Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulation

7 January 2021

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Probing of the membrane topology of sarcoplasmic reticulum Ca2+-ATPase with sequence-specific antibodies. Evidence for plasticity of the c-terminal domain

7 January 2021

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Expression of endoplasmic-reticulum Ca2(+)-pump isoforms and of phospholamban in pig smooth-muscle tissues

7 January 2021

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Antibodies against the non-muscle isoform of the endoplasmic reticulum Ca2(+)-transport ATPase

7 January 2021

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Mutation Lys758 --> Ile of the sarcoplasmic reticulum Ca2+-ATPase enhances dephosphorylation of E2P and inhibits the E2 to E1Ca2 transition

7 January 2021

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Ca2+ uptake by the sarcoplasmic reticulum in ventricular myocytes of the SERCA2b/b mouse is impaired at higher Ca2+ loads only

7 January 2021

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Functional difference between SERCA2a and SERCA2b Ca2+ pumps and their modulation by phospholamban

7 January 2021

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New concepts in diastolic dysfunction and diastolic heart failure: Part I: diagnosis, prognosis, and measurements of diastolic function

7 January 2021

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Minimal force-frequency modulation of inotropy and relaxation of in situ murine heart

7 January 2021

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Transgenic Galphaq overexpression induces cardiac contractile failure in mice

7 January 2021

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Disruption of a single copy of the SERCA2 gene results in altered Ca2+ homeostasis and cardiomyocyte function.

7 January 2021

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Enhanced myocyte contractility and Ca2+ handling in a calcineurin transgenic model of heart failure

7 January 2021

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Excessive sarcoplasmic/endoplasmic reticulum Ca2+-ATPase expression causes increased sarcoplasmic reticulum Ca2+ uptake but decreases myocyte shortening.

7 January 2021

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An overview of stress echocardiography in the study of patients with dilated or hypertrophic cardiomyopathy

7 January 2021

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Cardiac-specific overexpression of phospholamban alters calcium kinetics and resultant cardiomyocyte mechanics in transgenic mice

7 January 2021

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The presence of Lys27 instead of Asn27 in human phospholamban promotes sarcoplasmic reticulum Ca2+-ATPase superinhibition and cardiac remodeling

7 January 2021

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7 January 2021

Identifiers

DOI

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26 December 2019

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