Human midsized neurofilament subunit induces motor neuron disease in transgenic mice (Q79322910)

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21 December 2019

title

Human midsized neurofilament subunit induces motor neuron disease in transgenic mice (English)

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21 December 2019

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Miguel A Gama Sosa

1

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21 December 2019

Victor L Friedrich

2

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21 December 2019

Rita DeGasperi

3

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21 December 2019

Kevin Kelley

4

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21 December 2019

Paul H Wen

5

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21 December 2019

Emir Senturk

6

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21 December 2019

Robert A Lazzarini

7

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21 December 2019

Gregory A Elder

8

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21 December 2019

language of work or name

English

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publication date

1 November 2003

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21 December 2019

published in

Experimental Neurology

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21 December 2019

volume

184

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21 December 2019

issue

1

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21 December 2019

page(s)

408-419

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Formation of intermediate filament protein aggregates with disparate effects in two transgenic mouse models lacking the neurofilament light subunit

21 December 2019

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Late onset of motor neurons in mice overexpressing wild-type peripherin

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Selective distribution of the 57 kDa neural intermediate filament protein in the rat CNS.

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Neurofilament (NF) assembly; divergent characteristics of human and rodent NF-L subunits.

7 January 2021

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Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: a mouse model of amyotrophic lateral sclerosis

7 January 2021

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Absence of the mid-sized neurofilament subunit decreases axonal calibers, levels of light neurofilament (NF-L), and neurofilament content

7 January 2021

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Requirement of heavy neurofilament subunit in the development of axons with large calibers

7 January 2021

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Neurofilament-deficient axons and perikaryal aggregates in viable transgenic mice expressing a neurofilament-beta-galactosidase fusion protein

7 January 2021

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BAC and PAC DNA for the generation of transgenic animals.

7 January 2021

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Organization of mammalian neurofilament polypeptides within the neuronal cytoskeleton

7 January 2021

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Cytoskeletal abnormalities in amyotrophic lateral sclerosis: beneficial or detrimental effects?

7 January 2021

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Antagonistic roles of neurofilament subunits NF-H and NF-M against NF-L in shaping dendritic arborization in spinal motor neurons

7 January 2021

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A mutant neurofilament subunit causes massive, selective motor neuron death: implications for the pathogenesis of human motor neuron disease

7 January 2021

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Expression of human mid-sized neurofilament subunit in transgenic mice

7 January 2021

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Identification of the major multiphosphorylation site in mammalian neurofilaments

7 January 2021

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The structure and organization of the human heavy neurofilament subunit (NF-H) and the gene encoding it

7 January 2021

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Structure and evolutionary origin of the gene encoding mouse NF-M, the middle-molecular-mass neurofilament protein.

7 January 2021

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Neurofilament subunit NF-H modulates axonal diameter by selectively slowing neurofilament transport

7 January 2021

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Extra neurofilament NF-L subunits rescue motor neuron disease caused by overexpression of the human NF-H gene in mice.

7 January 2021

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Antibody labeling of bovine neurofilaments: implications on the structure of neurofilament sidearms*1

7 January 2021

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The human mid-size neurofilament subunit: a repeated protein sequence and the relationship of its gene to the intermediate filament gene family

7 January 2021

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Neurofilament-dependent radial growth of motor axons and axonal organization of neurofilaments does not require the neurofilament heavy subunit (NF-H) or its phosphorylation

7 January 2021

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The structure of the largest murine neurofilament protein (NF-H) as revealed by cDNA and genomic sequences

7 January 2021

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Overexpression of the human NFM subunit in transgenic mice modifies the level of endogenous NFL and the phosphorylation state of NFH subunits

7 January 2021

1 reference

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Age-associated and cell-type-specific neurofibrillary pathology in transgenic mice expressing the human midsized neurofilament subunit

7 January 2021

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Increasing neurofilament subunit NF-M expression reduces axonal NF-H, inhibits radial growth, and results in neurofilamentous accumulation in motor neurons.

7 January 2021

1 reference

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Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease

7 January 2021

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Subunit composition of neurofilaments specifies axonal diameter.

7 January 2021

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Delayed maturation of regenerating myelinated axons in mice lacking neurofilaments

7 January 2021

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Disruption of the NF-H gene increases axonal microtubule content and velocity of neurofilament transport: relief of axonopathy resulting from the toxin beta,beta'-iminodipropionitrile

7 January 2021

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10.1016/S0014-4886(03)00206-1

7 January 2021

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14637110%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

1 reference