IFN-gamma represses IL-4 expression via IRF-1 and IRF-2 (Q78651172)

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15 December 2019

title

IFN-gamma represses IL-4 expression via IRF-1 and IRF-2 (English)

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15 December 2019

author name string

Bernd Elser

1

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15 December 2019

Michael Lohoff

2

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15 December 2019

Sonja Kock

3

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15 December 2019

Marco Giaisi

4

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15 December 2019

Sabine Kirchhoff

5

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15 December 2019

Peter H Krammer

6

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15 December 2019

Min Li-Weber

7

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15 December 2019

publication date

1 December 2002

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15 December 2019

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15 December 2019

volume

17

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15 December 2019

issue

6

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15 December 2019

page(s)

703-712

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Functional diversity of helper T lymphocytes

15 December 2019

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Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system

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7 January 2021

The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4.

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7 January 2021

c-maf promotes T helper cell type 2 (Th2) and attenuates Th1 differentiation by both interleukin 4-dependent and -independent mechanisms

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7 January 2021

Interleukin (IL)-4 is a major regulatory cytokine governing bioactive IL-12 production by mouse and human dendritic cells

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Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice

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NF-AT-Driven interleukin-4 transcription potentiated by NIP45

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Stat6 is required for mediating responses to IL-4 and for development of Th2 cells.

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Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

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Essential and non-redundant roles of p48 (ISGF3 gamma) and IRF-1 in both type I and type II interferon responses, as revealed by gene targeting studies

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7 January 2021

Interferon regulatory factor 1 (IRF-1) mediates cell growth inhibition by transactivation of downstream target genes.

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7 January 2021

Interplay between repressing and activating domains defines the transcriptional activity of IRF-1.

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7 January 2021

Activation interferes with the APO-1 pathway in mature human T cells.

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7 January 2021

Disruption of the murine IL-4 gene blocks Th2 cytokine responses.

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7 January 2021

Generation and analysis of interleukin-4 deficient mice

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Involvement of Jun and Rel proteins in up-regulation of interleukin-4 gene activity by the T cell accessory molecule CD28.

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Interferon regulatory factor-1 is required for a T helper 1 immune response in vivo

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7 January 2021

Deficiency in the transcription factor interferon regulatory factor (IRF)-2 leads to severely compromised development of natural killer and T helper type 1 cells

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7 January 2021

Type 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases.

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7 January 2021

The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells

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7 January 2021

IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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Activation of a cell-cycle-regulated histone gene by the oncogenic transcription factor IRF-2.

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7 January 2021

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Identifiers

DOI

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15 December 2019

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