BAX translocation is a critical event in neuronal apoptosis: regulation by neuroprotectants, BCL-2, and caspases (Q78166402)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10460254%20AND%20SRC:MED&resulttype=core&format=json

11 December 2019

title

BAX translocation is a critical event in neuronal apoptosis: regulation by neuroprotectants, BCL-2, and caspases (English)

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11 December 2019

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G V Putcha

1

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11 December 2019

M Deshmukh

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10460254%20AND%20SRC:MED&resulttype=core&format=json

11 December 2019

E M Johnson

series ordinal

3

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11 December 2019

publication date

1 September 1999

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11 December 2019

published in

Journal of Neuroscience

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11 December 2019

volume

19

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11 December 2019

issue

17

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11 December 2019

page(s)

7476-7485

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Bax deletion further orders the cell death pathway in cerebellar granule cells and suggests a caspase-independent pathway to cell death.

11 December 2019

cites work

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12 December 2020

Placement of the BCL2 family member BAX in the death pathway of sympathetic neurons activated by trophic factor deprivation.

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12 December 2020

Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis

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12 December 2020

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

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12 December 2020

Role for Bcl-xL as an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis

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12 December 2020

Role of BCL-2 in the survival and function of developing and mature sympathetic neurons

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12 December 2020

Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons

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12 December 2020

BAX is required for neuronal death after trophic factor deprivation and during development

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12 December 2020

Nerve growth factor regulates sympathetic ganglion cell morphology and survival in the adult mouse

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12 December 2020

Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex

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12 December 2020

BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases

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12 December 2020

Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9

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12 December 2020

Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor

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12 December 2020

Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

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12 December 2020

Injected cytochrome c induces apoptosis

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12 December 2020

The release of cytochrome c from mitochondria during apoptosis of NGF-deprived sympathetic neurons is a reversible event

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12 December 2020

The death programme in cultured sympathetic neurones can be suppressed at the posttranslational level by nerve growth factor, cyclic AMP, and depolarization

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12 December 2020

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

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12 December 2020

DESTRUCTION OF THE SYMPATHETIC GANGLIA IN MAMMALS BY AN ANTISERUM TO A NERVE-GROWTH PROTEIN.

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12 December 2020

Experimental autoimmune model of nerve growth factor deprivation: Effects on developing peripheral sympathetic and sensory neurons

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12 December 2020

Redistribution of Bax from cytosol to membranes is induced by apoptotic stimuli and is an early step in the apoptotic pathway

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12 December 2020

Bax-induced cytochrome C release from mitochondria is independent of the permeability transition pore but highly dependent on Mg2+ ions

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12 December 2020

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

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12 December 2020

Genetic and metabolic status of NGF-deprived sympathetic neurons saved by an inhibitor of ICE family proteases

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12 December 2020

Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c

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12 December 2020

Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia.

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12 December 2020

Differential requirement for caspase 9 in apoptotic pathways in vivo.

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12 December 2020

Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death

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12 December 2020

Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

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12 December 2020

Cell-specific induction of apoptosis by microinjection of cytochrome c. Bcl-xL has activity independent of cytochrome c release

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12 December 2020

Role of Ca2+ channels in the ability of membrane depolarization to prevent neuronal death induced by trophic-factor deprivation: evidence that levels of internal Ca2+ determine nerve growth factor dependence of sympathetic ganglion cells

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12 December 2020

Bax-deficient mice with lymphoid hyperplasia and male germ cell death

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12 December 2020

Involvement of caspases in sympathetic neuron apoptosis

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12 December 2020

Widespread elimination of naturally occurring neuronal death in Bax-deficient mice

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12 December 2020

Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation

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12 December 2020

Analysis of the mechanism of loss of trophic factor dependence associated with neuronal maturation: a phenotype indistinguishable from Bax deletion.

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12 December 2020

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

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12 December 2020

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

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12 December 2020

Bcl-xL functions downstream of caspase-8 to inhibit Fas- and tumor necrosis factor receptor 1-induced apoptosis of MCF7 breast carcinoma cells

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12 December 2020

Activation of the CED3/ICE-related protease CPP32 in cerebellar granule neurons undergoing apoptosis but not necrosis

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12 December 2020

Chronic depolarization prevents programmed death of sympathetic neurons in vitro but does not support growth: requirement for Ca2+ influx but not Trk activation

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12 December 2020

Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xL.

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12 December 2020

cAMP analogs promote survival and neurite outgrowth in cultures of rat sympathetic and sensory neurons independently of nerve growth factor

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12 December 2020

Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes

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12 December 2020

Endogenous bax translocation in SH-SY5Y human neuroblastoma cells and cerebellar granule neurons undergoing apoptosis.

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12 December 2020

Bax deficiency prevents the increased cell death of immature neurons in bcl-x-deficient mice

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12 December 2020

Regulated targeting of BAX to mitochondria.

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12 December 2020

Role of hypoxia-induced Bax translocation and cytochrome c release in reoxygenation injury

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12 December 2020

Movement of Bax from the cytosol to mitochondria during apoptosis

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12 December 2020

Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria

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12 December 2020

The contrasting roles of ICE family proteases and interleukin-1beta in apoptosis induced by trophic factor withdrawal and by copper/zinc superoxide dismutase down-regulation

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12 December 2020

Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis

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12 December 2020

In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system

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12 December 2020

Human IAP-like protein regulates programmed cell death downstream of Bcl-xL and cytochrome c

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12 December 2020

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

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12 December 2020

Blocking cytochrome c activity within intact neurons inhibits apoptosis.

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12 December 2020

Techniques in the tissue culture of rat sympathetic neurons

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12 December 2020

Evidence of a novel event during neuronal death: development of competence-to-die in response to cytoplasmic cytochrome c

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12 December 2020

10.1523/JNEUROSCI.19-17-07476.1999

Identifiers

DOI

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11 December 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10460254%20AND%20SRC:MED&resulttype=core&format=json

11 December 2019

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