Homology modelling of human cytochromes P450 involved in xenobiotic metabolism and rationalization of substrate selectivity (Q78120133)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10445400%20AND%20SRC:MED&resulttype=core&format=json

11 December 2019

title

Homology modelling of human cytochromes P450 involved in xenobiotic metabolism and rationalization of substrate selectivity (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10445400%20AND%20SRC:MED&resulttype=core&format=json

11 December 2019

author name string

D F Lewis

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10445400%20AND%20SRC:MED&resulttype=core&format=json

11 December 2019

publication date

1 July 1999

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10445400%20AND%20SRC:MED&resulttype=core&format=json

Experimental and Toxicologic Pathology

11 December 2019

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10445400%20AND%20SRC:MED&resulttype=core&format=json

11 December 2019

volume

51

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11 December 2019

issue

4-5

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11 December 2019

page(s)

369-374

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Cytochrome P450 proteins and potential utilization in biodegradation

11 December 2019

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Xenobiotic-metabolizing cytochrome P450 enzymes in the human feto-placental unit: role in intrauterine toxicity

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Competitive inhibition of coumarin 7-hydroxylation by pilocarpine and its interaction with mouse CYP 2A5 and human CYP 2A6

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Three-dimensional models of human and other mammalian microsomal P450s constructed from an alignment with P450102 (P450bm3)

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Molecular modelling and quantitative structure-activity relationship studies on the interaction of omeprazole with cytochrome P450 isozymes

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Molecular modelling of CYP2E1 enzymes from rat, mouse and man: an explanation for species differences in butadiene metabolism and potential carcinogenicity, and rationalization of CYP2E substrate specificity

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Molecular modelling of human CYP2C subfamily enzymes CYP2C9 and CYP2C19: rationalization of substrate specificity and site-directed mutagenesis experiments in the CYP2C subfamily

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7 January 2021

Structural determinants of cytochrome P450 substrate specificity, binding affinity and catalytic rate

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Molecular modelling of CYP3A4 from an alignment with CYP102: identification of key interactions between putative active site residues and CYP3A-specific chemicals

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Evolution of the cytochrome P450 superfamily: sequence alignments and pharmacogenetics

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The structure of the cytochrome p450BM-3 haem domain complexed with the fatty acid substrate, palmitoleic acid

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Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue

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P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.

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The metabolism of tamoxifen by human cytochromes P450 is rationalized by molecular modelling of the enzyme-substrate interactions: potential importance to its proposed anti-carcinogenic/carcinogenic actions

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7 January 2021

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Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10445400%20AND%20SRC:MED&resulttype=core&format=json

11 December 2019

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