L-374,087, an efficacious, orally bioavailable, pyridinone acetamide thrombin inhibitor (Q77743915)

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8 December 2019

title

L-374,087, an efficacious, orally bioavailable, pyridinone acetamide thrombin inhibitor (English)

1 reference

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8 December 2019

author name string

P E Sanderson

1

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8 December 2019

K J Cutrona

2

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8 December 2019

B D Dorsey

3

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8 December 2019

D L Dyer

4

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8 December 2019

C M McDonough

5

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8 December 2019

A M Naylor-Olsen

6

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I W Chen

7

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8 December 2019

Z Chen

8

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8 December 2019

J J Cook

9

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8 December 2019

S J Gardell

10

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8 December 2019

J A Krueger

11

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S D Lewis

12

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8 December 2019

J H Lin

13

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8 December 2019

B J Lucas

14

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E A Lyle

15

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J J Lynch

16

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M T Stranieri

17

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K Vastag

18

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J A Shafer

19

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J P Vacca

20

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publication date

1 April 1998

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Bioorganic & Medicinal Chemistry Letters

8 December 2019

published in

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volume

8

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issue

7

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8 December 2019

page(s)

817-822

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Synthetic low-molecular weight thrombin inhibitors: the ideal antithrombotic drug? An introduction

8 December 2019

cites work

1 reference

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7 January 2021

Challenges in the development of orally bioavailable thrombin active site inhibitors

1 reference

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7 January 2021

Orally effective CVS-1123 prevents coronary artery thrombosis in the conscious dog.

1 reference

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7 January 2021

CVS-1123, a direct thrombin inhibitor, prevents occlusive arterial and venous thrombosis in a canine model of vascular injury

1 reference

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7 January 2021

Discovery and development of the novel potent orally active thrombin inhibitor N-(9-hydroxy-9-fluorenecarboxy)prolyl trans-4-aminocyclohexylmethyl amide (L-372,460): coapplication of structure-based design and rapid multiple analogue synthesis on so

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7 January 2021

Potent noncovalent thrombin inhibitors that utilize the unique amino acid D-dicyclohexylalanine in the P3 position. Implications on oral bioavailability and antithrombotic efficacy

1 reference

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7 January 2021

Discovery of a novel, selective, and orally bioavailable class of thrombin inhibitors incorporating aminopyridyl moieties at the P1 position

1 reference

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7 January 2021

Design of highly potent noncovalent thrombin inhibitors that utilize a novel lipophilic binding pocket in the thrombin active site

1 reference

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7 January 2021

Crystal structure of human alpha-thrombin complexed with hirugen and p-amidinophenylpyruvate at 1.6 A resolution

1 reference

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7 January 2021

Inhibition of thrombin and other trypsin-like serine proteinases by cyclotheonamide A

1 reference

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7 January 2021

Potent and selective thrombin inhibitors incorporating the constrained arginine mimic l-3-piperidyl(N-guanidino)alanine at P1.

1 reference

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7 January 2021

Design, synthesis, and evolution of a novel, selective, and orally bioavailable class of thrombin inhibitors: P1-argininal derivatives incorporating P3-P4 lactam sulfonamide moieties

1 reference

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7 January 2021

Design and synthesis of potent and highly selective thrombin inhibitors

1 reference

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7 January 2021

Rat model of arterial thrombosis induced by ferric chloride

1 reference

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7 January 2021

10.1016/S0960-894X(98)00117-6

Identifiers

DOI

1 reference

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8 December 2019

1 reference