Evaluating precursor-directed biosynthesis towards novel erythromycins through in vitro studies on a bimodular polyketide synthase (Q77716392)

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7 December 2019

title

Evaluating precursor-directed biosynthesis towards novel erythromycins through in vitro studies on a bimodular polyketide synthase (English)

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7 December 2019

author name string

K J Weissman

1

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7 December 2019

M Bycroft

2

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7 December 2019

A L Cutter

3

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7 December 2019

U Hanefeld

4

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7 December 2019

E J Frost

5

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7 December 2019

M C Timoney

6

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7 December 2019

R Harris

7

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7 December 2019

S Handa

8

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7 December 2019

M Roddis

9

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7 December 2019

J Staunton

10

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7 December 2019

P F Leadlay

11

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7 December 2019

publication date

1 December 1998

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7 December 2019

published in

Chemistry and Biology

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7 December 2019

volume

5

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7 December 2019

issue

12

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7 December 2019

page(s)

743-754

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An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea.

7 December 2019

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Modular organization of genes required for complex polyketide biosynthesis

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6-Deoxyerythronolide-B synthase 2 from Saccharopolyspora erythraea. Cloning of the structural gene, sequence analysis and inferred domain structure of the multifunctional enzyme.

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Characterisation of a Streptomyces antibioticus gene encoding a type I polyketide synthase which has an unusual coding sequence.

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Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase

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Identification of DEBS 1, DEBS 2 and DEBS 3, the multienzyme polypeptides of the erythromycin-producing polyketide synthase from Saccharopolyspora erythraea

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Polyketide synthase gene manipulation: a structure-function approach in engineering novel antibiotics

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Combinatorial approaches to polyketide biosynthesis

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Generation of polyketide libraries via combinatorial biosynthesis

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Combinatorial biosynthesis of erythromycin and complex polyketides

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Novel avermectins produced by mutational biosynthesis.

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Engineering broader specificity into an antibiotic-producing polyketide synthase.

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Precursor-directed biosynthesis of erythromycin analogs by an engineered polyketide synthase

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Macrolide biosynthesis. 7. Incorporation of polyketide chain elongation intermediates into methymycin

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Avermectin biosynthesis. Intact incorporation of a diketide chain-assembly intermediate into the polyketide macrocyclic ring

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6-deoxyerythronolide B synthase 1 is specifically acylated by a diketide intermediate at the beta-ketoacyl-acyl carrier protein synthase domain of module 2

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7 January 2021

Molecular recognition of diketide substrates by a beta-ketoacyl-acyl carrier protein synthase domain within a bimodular polyketide synthase

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7 January 2021

Stereospecific acyl transfers on the erythromycin-producing polyketide synthase

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7 January 2021

Erythromycin biosynthesis: kinetic studies on a fully active modular polyketide synthase using natural and unnatural substrates

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7 January 2021

Purification and characterization of bimodular and trimodular derivatives of the erythromycin polyketide synthase

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7 January 2021

Repositioning of a domain in a modular polyketide synthase to promote specific chain cleavage

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7 January 2021

Origin of starter units for erythromycin biosynthesis.

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7 January 2021

Polyketide synthesis in vitro on a modular polyketide synthase

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7 January 2021

The Molecular Basis of Celmer's Rules: The Stereochemistry of the Condensation Step in Chain Extension on the Erythromycin Polyketide Synthase†

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7 January 2021

The Thioesterase of the Erythromycin-Producing Polyketide Synthase: Influence of Acyl Chain Structure on the Mode of Release of Substrate Analogues from the Acyl Enzyme Intermediates

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7 January 2021

The loading domain of the erythromycin polyketide synthase is not essential for erythromycin biosynthesis in Saccharopolyspora erythraea

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7 January 2021

Heterologous expression in Escherichia coli of an intact multienzyme component of the erythromycin-producing polyketide synthase

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7 January 2021

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A useful 12-I-5 triacetoxyperiodinane (the Dess-Martin periodinane) for the selective oxidation of primary or secondary alcohols and a variety of related 12-I-5 species

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Identifiers

DOI

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7 December 2019

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