Amino acid residue 200 on the alpha1 subunit of GABA(A) receptors affects the interaction with selected benzodiazepine binding site ligands (Q77354747)

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4 December 2019

title

Amino acid residue 200 on the alpha1 subunit of GABA(A) receptors affects the interaction with selected benzodiazepine binding site ligands (English)

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4 December 2019

author name string

Schaerer MT

1

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4 December 2019

Buhr A

2

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4 December 2019

Baur R

3

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4 December 2019

Sigel E

4

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4 December 2019

publication date

1 August 1998

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European Journal of Pharmacology

4 December 2019

published in

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4 December 2019

volume

354

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4 December 2019

issue

2-3

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4 December 2019

page(s)

283-287

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GABAA receptor needs two homologous domains of the beta-subunit for activation by GABA but not by pentobarbital.

4 December 2019

cites work

1 reference

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A point mutation in the gamma2 subunit of gamma-aminobutyric acid type A receptors results in altered benzodiazepine binding site specificity

7 January 2021

1 reference

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Subtle changes in residue 77 of the gamma subunit of alpha1beta2gamma2 GABAA receptors drastically alter the affinity for ligands of the benzodiazepine binding site

7 January 2021

1 reference

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High-efficiency transformation of mammalian cells by plasmid DNA

7 January 2021

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

7 January 2021

1 reference

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Benzodiazepine-induced motor impairment linked to point mutation in cerebellar GABAA receptor.

7 January 2021

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GABAA-receptor expressed from rat brain alpha- and beta-subunit cDNAs displays potentiation by benzodiazepine receptor ligands

7 January 2021

1 reference

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Functional characteristics and sites of gene expression of the alpha 1, beta 1, gamma 2-isoform of the rat GABAA receptor

7 January 2021

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Quaternary structure of the native GABAA receptor determined by electron microscopic image analysis.

7 January 2021

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gamma-Aminobutyric acid type A receptor point mutation increases the affinity of compounds for the benzodiazepine site

7 January 2021

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From ion currents to genomic analysis: recent advances in GABAA receptor research.

7 January 2021

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Point mutations affecting antagonist affinity and agonist dependent gating of GABAA receptor channels.

7 January 2021

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Four amino acid exchanges convert a diazepam-insensitive, inverse agonist-preferring GABAA receptor into a diazepam-preferring GABAA receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900456-7

Key amino acids in the gamma subunit of the gamma-aminobutyric acidA receptor that determine ligand binding and modulation at the benzodiazepine site.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900456-7

Two tyrosine residues on the alpha subunit are crucial for benzodiazepine binding and allosteric modulation of gamma-aminobutyric acidA receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900456-7

inferred from DOI database lookup

7 January 2021

based on heuristic

Residues at positions 206 and 209 of the alpha1 subunit of gamma-aminobutyric AcidA receptors influence affinities for benzodiazepine binding site ligands

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900456-7

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0014-2999(98)00456-7

1 reference

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4 December 2019

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