Gluten induces an intestinal cytokine response strongly dominated by interferon gamma in patients with celiac disease (Q77164863)

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3 December 2019

title

Gluten induces an intestinal cytokine response strongly dominated by interferon gamma in patients with celiac disease (English)

1 reference

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3 December 2019

author name string

E M Nilsen

1

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3 December 2019

F L Jahnsen

2

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3 December 2019

K E Lundin

3

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3 December 2019

F E Johansen

4

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3 December 2019

O Fausa

5

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3 December 2019

L M Sollid

6

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3 December 2019

J Jahnsen

7

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3 December 2019

H Scott

8

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3 December 2019

P Brandtzaeg

9

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3 December 2019

language of work or name

English

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publication date

1 September 1998

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3 December 2019

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3 December 2019

volume

115

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3 December 2019

page(s)

551-563

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3 December 2019

issue

3

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3 December 2019

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Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue')

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Intraepithelial T cells of the TcR gamma/delta+ CD8- and V delta 1/J delta 1+ phenotypes are increased in coeliac disease

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Activated T lymphocytes in the celiac lesion: non-proliferative activation (CD25) of CD4+ alpha/beta cells in the lamina propria but proliferation (Ki-67) of alpha/beta and gamma/delta cells in the epithelium

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Gluten stimulation of coeliac mucosa in vitro induces activation (CD25) of lamina propria CD4+ T cells and macrophages but no crypt-cell hyperplasia

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Gliadin-specific, HLA-DQ(alpha 1*0501,beta 1*0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients

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T cells from the small intestinal mucosa of a DR4, DQ7/DR4, DQ8 celiac disease patient preferentially recognize gliadin when presented by DQ8.

7 January 2021

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Gluten specific, HLA-DQ restricted T cells from coeliac mucosa produce cytokines with Th1 or Th0 profile dominated by interferon gamma

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Triggered human mucosal T cells release tumour necrosis factor-alpha and interferon-gamma which kill human colonic epithelial cells

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Selective differentiation of CD4+ T helper cell subsets

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Th1 and Th2 subsets: paradigms lost?

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The expanding universe of T-cell subsets: Th1, Th2 and more.

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Revised criteria for diagnosis of coeliac disease. Report of Working Group of European Society of Paediatric Gastroenterology and Nutrition

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Detection of intracellular cytokines by flow cytometry

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Detection of interferon gamma mRNA in the mucosa of patients with coeliac disease by in situ hybridisation

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Definition of the initial immunologic modifications upon in vitro gliadin challenge in the small intestine of celiac patients

7 January 2021

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Histological changes in small bowel mucosa induced by gliadin sensitive T lymphocytes can be blocked by anti-interferon gamma antibody

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inferred from DOI database lookup

7 January 2021

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Identifiers

DOI

10.1016/S0016-5085(98)70134-9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9721152%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

1 reference