Fully automated analysis of activities catalysed by the major human liver cytochrome P450 (CYP) enzymes: assessment of human CYP inhibition potential (Q74608267)

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scientific article published on 01 January 1999

Language	Label	Description	Also known as
English	Fully automated analysis of activities catalysed by the major human liver cytochrome P450 (CYP) enzymes: assessment of human CYP inhibition potential	scientific article published on 01 January 1999

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10078840%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

Fully automated analysis of activities catalysed by the major human liver cytochrome P450 (CYP) enzymes: assessment of human CYP inhibition potential (English)

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Europe PubMed Central

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12 November 2019

author name string

G C Moody

1

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12 November 2019

S J Griffin

2

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12 November 2019

A N Mather

3

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12 November 2019

D F McGinnity

4

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12 November 2019

R J Riley

5

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12 November 2019

publication date

1 January 1999

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12 November 2019

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12 November 2019

29

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12 November 2019

1

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12 November 2019

53-75

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12 November 2019

Estradiol metabolism by complementary deoxyribonucleic acid-expressed human cytochrome P450s

1 reference

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In vitro inhibition studies of tolbutamide hydroxylase activity of human liver microsomes by azoles, sulphonamides and quinolines

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Ketoconazole and sulphaphenazole as the respective selective inhibitors of P4503A and 2C9

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Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions

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The role of cytochrome P4502D6 in the metabolism of paroxetine by human liver microsomes

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Inhibitory studies of mexiletine and dextromethorphan oxidation in human liver microsomes

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

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Characterization of the inhibition of P4501A2 by furafylline

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Microtiter plate assays for inhibition of human, drug-metabolizing cytochromes P450

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Dextromethorphan O-demethylation in liver microsomes as a prototype reaction to monitor cytochrome P-450 db1 activity

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Relationship between phenytoin and tolbutamide hydroxylations in human liver microsomes

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21 January 2018

Dextromethorphan as an in vivo probe for the simultaneous determination of CYP2D6 and CYP3A activity.

1 reference

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21 January 2018

Drug interactions and the cytochrome P450 system. The role of cytochrome P450 2C19.

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Xenobiotic and endobiotic inhibitors of cytochrome P-450dbl function, the target of the debrisoquine/sparteine type polymorphism

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21 January 2018

Characterization of dextromethorphan N-demethylation by human liver microsomes. Contribution of the cytochrome P450 3A (CYP3A) subfamily

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Metabolism of theophylline by cDNA-expressed human cytochromes P-450.

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An investigation of the interaction between halofantrine, CYP2D6 and CYP3A4: studies with human liver microsomes and heterologous enzyme expression systems

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21 January 2018

CYP2D6- and CYP3A-dependent metabolism of dextromethorphan in humans

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21 January 2018

The role of CYP2D6 in primary and secondary oxidative metabolism of dextromethorphan: in vitro studies using human liver microsomes

1 reference

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Primary and secondary oxidative metabolism of dextromethorphan

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21 January 2018

High-performance liquid chromatographic assays for bufuralol 1'-hydroxylase, debrisoquine 4-hydroxylase, and dextromethorphan O-demethylase in microsomes and purified cytochrome P-450 isozymes of human liver

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21 January 2018

Dextromethorphan as a safe probe for debrisoquine hydroxylation polymorphism

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21 January 2018

The Substrate Binding Site of Human Liver Cytochrome P450 2C9: An Approach Using Designed Tienilic Acid Derivatives and Molecular Modeling

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21 January 2018

Interaction of sulfaphenazole derivatives with human liver cytochromes P450 2C: molecular origin of the specific inhibitory effects of sulfaphenazole on CYP 2C9 and consequences for the substrate binding site topology of CYP 2C9

1 reference

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21 January 2018

Cytochromes P450, 1A2, and 2C9 are responsible for the human hepatic O-demethylation of R- and S-naproxen

1 reference

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21 January 2018

Specificity of substrate and inhibitor probes for cytochrome P450s: evaluation of in vitro metabolism using cDNA-expressed human P450s and human liver microsomes

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21 January 2018

Distinction of CYP1A1 and CYP1A2 activity by selective inhibition using fluvoxamine and isosafrole

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21 January 2018

In vitro analysis of the activity of the major human hepatic CYP enzyme (CYP3A4) using [N-methyl-14C]-erythromycin

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21 January 2018

Preclinical drug metabolism in the age of high-throughput screening: an industrial perspective

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Metabolism of dextromethorphan in vitro: involvement of cytochromes P450 2D6 and 3A3/4, with a possible role of 2E1.

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Furafylline is a potent and selective inhibitor of cytochrome P450IA2 in man.

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Involvement of multiple cytochrome P450 isoforms in naproxen O-demethylation

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Identifiers

10.1080/004982599238812

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10078840%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10078840%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

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