TP53 gene mutations, nuclear p53 accumulation, expression of Waf/p21, Bcl-2, and CD95 (APO-1/Fas) proteins are not prognostic factors in de novo glioblastoma multiforme (Q74418586)

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scientific article published on 01 May 2001

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English	TP53 gene mutations, nuclear p53 accumulation, expression of Waf/p21, Bcl-2, and CD95 (APO-1/Fas) proteins are not prognostic factors in de novo glioblastoma multiforme	scientific article published on 01 May 2001

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scholarly article

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10 November 2019

TP53 gene mutations, nuclear p53 accumulation, expression of Waf/p21, Bcl-2, and CD95 (APO-1/Fas) proteins are not prognostic factors in de novo glioblastoma multiforme (English)

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10 November 2019

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Andreas von Deimling

15

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10 November 2019

author name string

J A Kraus

1

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10 November 2019

M Wenghoefer

2

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10 November 2019

N Glesmann

3

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10 November 2019

S Mohr

4

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10 November 2019

M Beck

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M C Schmidt

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10 November 2019

R Schröder

7

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10 November 2019

U Berweiler

8

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10 November 2019

W Roggendorf

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10 November 2019

S Diete

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10 November 2019

K Dietzmann

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10 November 2019

K Heuser

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10 November 2019

B Müller

13

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10 November 2019

R Fimmers

14

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10 November 2019

U Schlegel

16

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10 November 2019

publication date

1 May 2001

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10 November 2019

Journal of Neuro-Oncology

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10 November 2019

52

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10 November 2019

3

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10 November 2019

263-272

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10 November 2019

https://scigraph.springernature.com/pub.10.1023/a:1010684203704

0 references

Bcl-2 distribution in neuroepithelial tumors: an immunohistochemical study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a p53-dependent negative response element in the bcl-2 gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Social controls on cell survival and cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene transfer of wild-type p53 results in restoration of tumor-suppressor function in a medulloblastoma cell line.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recursive partitioning analysis of prognostic factors in three Radiation Therapy Oncology Group malignant glioma trials.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparisons of carmustine, procarbazine, and high-dose methylprednisolone as additions to surgery and radiotherapy for the treatment of malignant glioma

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resection, biopsy, and survival in malignant glial neoplasms. A retrospective study of clinical parameters, therapy, and outcome.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of prognostic relevance of alterations in the epidermal growth factor receptor-transforming growth factor-alpha pathway in human astrocytic gliomas.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TP53 alterations and clinical outcome in low grade astrocytomas.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term glioblastoma multiforme survivors: a population-based study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ten-year survival among patients with supratentorial astrocytomas grade III and IV

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selection bias in clinical trials of anaplastic glioma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic significance of Bcl-2 in clinically localized prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Malignant glioma: who benefits from adjuvant chemotherapy?

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

bcl-2 expression, p53 accumulation, and apoptosis in ovarian carcinomas.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer. p53, guardian of the genome

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adenovirus-mediated transfer of the p53 gene produces rapid and generalized death of human glioma cells via apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis and immunohistochemical bcl-2 expression in colorectal adenomas and carcinomas. Aspects of carcinogenesis and prognostic significance

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl-2 protein: a prognostic factor inversely correlated to p53 in non-small-cell lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular pathogenesis of malignant gliomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 function influences the effect of fractionated radiotherapy on glioblastoma tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Response criteria for phase II studies of supratentorial malignant glioma

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 is required for radiation-induced apoptosis in mouse thymocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

WAF1, a potential mediator of p53 tumor suppression

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of malignant glioma in adults.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53, the cellular gatekeeper for growth and division

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term survivors of glioblastoma multiforme: clinical and molecular characteristics.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human gliomas with wild-type p53 express bcl-2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term survival in patients with glioblastoma multiforme

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis in cerebral astrocytic tumours and its relationship to expression of the bcl-2 and p53 proteins.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple polymorphisms, but no mutations, in the WAF1/CIP1 gene in human brain tumours

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 in tumour pathology: can we trust immunohistochemistry?--Revisited!

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single cell monitoring of growth arrest and morphological changes induced by transfer of wild-type p53 alleles to glioblastoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progression as exemplified by human astrocytic tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased levels of p21WAF1/Cip1 in human brain tumors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl-2 and the regulation of programmed cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of Bcl-2 in node-negative breast cancer is associated with various prognostic factors, but does not predict response to one course of perioperative chemotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of postoperative radiotherapy and combined postoperative radiotherapy and chemotherapy in the multidisciplinary management of malignant gliomas. A joint Radiation Therapy Oncology Group and Eastern Cooperative Oncology Group study

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The intrinsic radioresistance of glioblastoma-derived cell lines is associated with a failure of p53 to induce p21(BAX) expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of p53 and p21 functional interactions in glioma cells en route to apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Survival after stereotactic biopsy of malignant gliomas.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Randomized trial of three chemotherapy regimens and two radiotherapy regimens and two radiotherapy regimens in postoperative treatment of malignant glioma. Brain Tumor Cooperative Group Trial 8001.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alterations of the TP53 gene in human gliomas.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

bcl-2 protein expression in astrocytomas in relation to patient survival and p53 gene status.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

bcl-2 protein expression in tumors of the central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression level of Bcl-2 determines anti- or proapoptotic function.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in radiation sensitivity of human osteosarcoma cells after p53 introduction.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of CD95 (APO-1/Fas)-mediated apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic sub-types of human malignant astrocytoma correlate with survival.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Primary and secondary glioblastomas: from concept to clinical diagnosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term survival after the diagnosis of malignant glioma: a series of 22 patients surviving more than 4 years after diagnosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fas (APO-1/CD95) signaling pathway is intact in radioresistant human glioma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic value of bcl-2 immunoreactivity in medullary thyroid carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of treatment on long-term survivors with malignant astrocytomas.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The p53 gene and protein in human brain tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Shared allelic losses on chromosomes 1p and 19q suggest a common origin of oligodendroglioma and oligoastrocytoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53-dependent G1 arrest and p53-independent apoptosis influence the radiobiologic response of glioblastoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term survival in patients with malignant astrocytoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Bcl-2 protein family: arbiters of cell survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/11519857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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