Ran-mediated nuclear export of the von Hippel-Lindau tumor suppressor protein occurs independently of its assembly with cullin-2 (Q73561184)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10722748%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

title

Ran-mediated nuclear export of the von Hippel-Lindau tumor suppressor protein occurs independently of its assembly with cullin-2 (English)

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5 November 2019

author name string

I Groulx

series ordinal

1

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5 November 2019

M E Bonicalzi

series ordinal

2

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5 November 2019

S Lee

series ordinal

3

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5 November 2019

language of work or name

English

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publication date

1 March 2000

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Journal of Biological Chemistry

5 November 2019

published in

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5 November 2019

volume

275

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5 November 2019

page(s)

8991-9000

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5 November 2019

issue

12

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Identification of the von Hippel-Lindau disease tumor suppressor gene

5 November 2019

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The VHL tumour-suppressor gene paradigm

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The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal

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Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene

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Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein

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Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2

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The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix

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Alternate choice of initiation codon produces a biologically active product of the von Hippel Lindau gene with tumor suppressor activity

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pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation

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A second major native von Hippel-Lindau gene product, initiated from an internal translation start site, functions as a tumor suppressor.

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Inhibition of transcription elongation by the VHL tumor suppressor protein

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Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C

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The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

21 January 2018

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Protective function of von Hippel-Lindau protein against impaired protein processing in renal carcinoma cells

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Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

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The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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Immunostaining of the von Hippel-Lindau gene product in normal and neoplastic human tissues

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Nuclear/cytoplasmic localization of the von Hippel-Lindau tumor suppressor gene product is determined by cell density

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Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein

21 January 2018

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Subcellular localization of the von Hippel-Lindau disease gene product is cell cycle-dependent

21 January 2018

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Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA

21 January 2018

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Analysis of trafficking of Rev and transdominant Rev proteins in living cells using green fluorescent protein fusions: transdominant Rev blocks the export of Rev from the nucleus to the cytoplasm

21 January 2018

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21 January 2018

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Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors

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Reconstitution of HIV-1 rev nuclear export: independent requirements for nuclear import and export

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The GTP-binding protein Ran/TC4 is required for protein import into the nucleus

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm

21 January 2018

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Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6

21 January 2018

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A cytosolic activity distinct from crm1 mediates nuclear export of protein kinase inhibitor in permeabilized cells.

21 January 2018

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Subnuclear trafficking of glucocorticoid receptors in vitro: chromatin recycling and nuclear export

21 January 2018

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CRM1 is an export receptor for leucine-rich nuclear export signals

21 January 2018

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Regulation of CFTR chloride channels by syntaxin and Munc18 isoforms

21 January 2018

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Identification of a signal for rapid export of proteins from the nucleus

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.275.12.8991

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10722748%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

1 reference