Janus kinase 2-dependent activation of p38 mitogen-activated protein kinase by growth hormone. Resultant transcriptional activation of ATF-2 and CHOP, cytoskeletal re-organization and mitogenesis (Q73357698)

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scientific article published on 01 January 2000

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English	Janus kinase 2-dependent activation of p38 mitogen-activated protein kinase by growth hormone. Resultant transcriptional activation of ATF-2 and CHOP, cytoskeletal re-organization and mitogenesis	scientific article published on 01 January 2000

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3 November 2019

Janus kinase 2-dependent activation of p38 mitogen-activated protein kinase by growth hormone. Resultant transcriptional activation of ATF-2 and CHOP, cytoskeletal re-organization and mitogenesis (English)

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3 November 2019

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T Zhu

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P E Lobie

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Journal of Biological Chemistry

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2103-2114

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Signal TransductionThrough Cytokine Receptors

1 reference

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21 January 2018

Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase

1 reference

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21 January 2018

JAK2, Ras, and Raf are required for activation of extracellular signal-regulated kinase/mitogen-activated protein kinase by growth hormone

1 reference

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21 January 2018

Growth hormone and prolactin stimulate tyrosine phosphorylation of insulin receptor substrate-1, -2, and -3, their association with p85 phosphatidylinositol 3-kinase (PI3-kinase), and concomitantly PI3-kinase activation via JAK2 kinase

1 reference

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21 January 2018

Growth hormone stimulates the tyrosine phosphorylation of the insulin receptor substrate-1 and its association with phosphatidylinositol 3-kinase in primary adipocytes

1 reference

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21 January 2018

Growth Hormone-promoted Tyrosyl Phosphorylation of SHC Proteins and SHC Association with Grb2

1 reference

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21 January 2018

Identification of SH2-Bbeta as a substrate of the tyrosine kinase JAK2 involved in growth hormone signaling

1 reference

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21 January 2018

Interaction of Growth Hormone-activated STATs with SH2-containing Phosphotyrosine Phosphatase SHP-1 and Nuclear JAK2 Tyrosine Kinase

1 reference

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21 January 2018

Involvement of the Src homology 2-containing tyrosine phosphatase SHP-2 in growth hormone signaling

1 reference

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21 January 2018

Growth hormone stimulates the tyrosine phosphorylation and association of p125 focal adhesion kinase (FAK) with JAK2. Fak is not required for stat-mediated transcription

1 reference

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21 January 2018

Growth hormone stimulates the formation of a multiprotein signaling complex involving p130(Cas) and CrkII. Resultant activation of c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK).

1 reference

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21 January 2018

Organization and regulation of mitogen-activated protein kinase signaling pathways

1 reference

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21 January 2018

Increasing complexity of the Ras signaling pathway.

1 reference

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21 January 2018

Hemopoietic growth factors with the exception of interleukin-4 activate the p38 mitogen-activated protein kinase pathway

1 reference

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21 January 2018

p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells.

1 reference

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21 January 2018

Cooperation of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways during granulocyte colony-stimulating factor-induced hemopoietic cell proliferation

1 reference

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21 January 2018

A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells

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21 January 2018

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

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21 January 2018

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1 reference

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21 January 2018

Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine

1 reference

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21 January 2018

Activation of the MAP kinase homologue RK requires the phosphorylation of Thr-180 and Tyr-182 and both residues are phosphorylated in chemically stressed KB cells

1 reference

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21 January 2018

Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta)

1 reference

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21 January 2018

Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles

1 reference

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21 January 2018

ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation

1 reference

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21 January 2018

Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38)

1 reference

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21 January 2018

MEKKs, GCKs, MLKs, PAKs, TAKs, and tpls: upstream regulators of the c-Jun amino-terminal kinases?

1 reference

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21 January 2018

Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1 reference

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21 January 2018

Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1.

1 reference

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21 January 2018

Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation

1 reference

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21 January 2018

Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting [...]

1 reference

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21 January 2018

A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3

1 reference

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21 January 2018

Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

1 reference

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21 January 2018

Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart

1 reference

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21 January 2018

Activation of p38 mitogen-activated protein kinase by PYK2/related adhesion focal tyrosine kinase-dependent mechanism

1 reference

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21 January 2018

Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms

1 reference

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21 January 2018

Characterization of the structure and function of a novel MAP kinase kinase (MKK6)

1 reference

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21 January 2018

MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway

1 reference

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21 January 2018

Cloning and characterization of MEK6, a novel member of the mitogen-activated protein kinase kinase cascade

1 reference

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21 January 2018

Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase

1 reference

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21 January 2018

Role of p38 and JNK mitogen-activated protein kinases in the activation of ternary complex factors

1 reference

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21 January 2018

CREB is activated by UVC through a p38/HOG-1-dependent protein kinase

1 reference

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21 January 2018

RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK)

1 reference

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21 January 2018

Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation

1 reference

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21 January 2018

p38 mitogen-activated protein kinase pathway promotes skeletal muscle differentiation. Participation of the Mef2c transcription factor

1 reference

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21 January 2018

Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors

1 reference

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21 January 2018

PRAK, a novel protein kinase regulated by the p38 MAP kinase

1 reference

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21 January 2018

Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase

1 reference

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21 January 2018

Constitutive nuclear localization of Janus kinases 1 and 2

1 reference

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21 January 2018

Specificity of transcription enhancement via the STAT responsive element in the serine protease inhibitor 2.1 promoter

1 reference

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21 January 2018

Evidence for an Endogenous Ultradian Rhythm Governing Growth Hormone Secretion in the Rat

1 reference

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21 January 2018

Effects of Preincubation on the Ability of Rat Adipocytes to Bind and Respond to Growth Hormone*

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21 January 2018

Controlling signaling with a specifically designed Gi-coupled receptor

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21 January 2018

How proteolysis drives the cell cycle

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21 January 2018

Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor

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21 January 2018

Fyn and JAK2 mediate Ras activation by reactive oxygen species

1 reference

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21 January 2018

Inhibition of v-raf-dependent c-fos expression and transformation by a kinase-defective mutant of the mitogen-activated protein kinase Erk2.

1 reference

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21 January 2018

Transcriptional regulation by extracellular signals: mechanisms and specificity

1 reference

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21 January 2018

Growth hormone stimulates phosphorylation and activation of elk-1 and expression of c-fos, egr-1, and junB through activation of extracellular signal-regulated kinases 1 and 2.

1 reference

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21 January 2018

Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor

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21 January 2018

PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

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21 January 2018

Cell stress and MKK6b-mediated p38 MAP kinase activation inhibit tumor necrosis factor-induced IkappaB phosphorylation and NF-kappaB activation

1 reference

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21 January 2018

Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1.

1 reference

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21 January 2018

A role for the p38 mitogen-activated protein kinase/Hsp 27 pathway in cholecystokinin-induced changes in the actin cytoskeleton in rat pancreatic acini

1 reference

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21 January 2018

Autocrine stimulation of human mammary carcinoma cell proliferation by human growth hormone

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21 January 2018

Growth hormone receptor C-terminal domains required for growth hormone-induced intracellular free Ca2+ oscillations and gene transcription

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21 January 2018

Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway

1 reference

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21 January 2018

Protein tyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPK and Stat1 in IFN-gamma, but not IFN-alpha, signaling

1 reference

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21 January 2018

Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone

1 reference

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21 January 2018

Transcription factor ATF2 regulation by the JNK signal transduction pathway

1 reference

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21 January 2018

Growth hormone induces expression of c-jun and jun B oncogenes and employs a protein kinase C signal transduction pathway for the induction of c-fos oncogene expression

1 reference

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21 January 2018

The N-terminal transactivation domain of ATF2 is a target for the co-operative activation of the c-jun promoter by p300 and 12S E1A

1 reference

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21 January 2018

Transcription factor ATF2 cooperates with v-Jun to promote growth factor-independent proliferation in vitro and tumor formation in vivo

1 reference

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21 January 2018

Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells

1 reference

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21 January 2018

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

1 reference

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21 January 2018

Amino Acid Limitation Induces Expression ofCHOP, a CCAAT/Enhancer Binding Protein-related Gene, at Both Transcriptional and Post-transcriptional Levels

1 reference

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21 January 2018

Ternary complex factors Elk-1 and Sap-1a mediate growth hormone-induced transcription of egr-1 (early growth response factor-1) in 3T3-F442A preadipocytes

1 reference

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21 January 2018

p38 mitogen-activated protein kinase functionally contributes to chondrogenesis induced by growth/differentiation factor-5 in ATDC5 cells

1 reference

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21 January 2018

Targeted down-regulation of caveolin-3 is sufficient to inhibit myotube formation in differentiating C2C12 myoblasts. Transient activation of p38 mitogen-activated protein kinase is required for induction of caveolin-3 expression and subsequent myot

1 reference

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21 January 2018

Changes in the phosphorylation status of the 27 kDa heat shock protein (HSP27) associated with the modulation of growth and/or differentiation in MCF-7 cells

1 reference

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21 January 2018

SAPK2/p38-dependent F-actin reorganization regulates early membrane blebbing during stress-induced apoptosis

1 reference

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21 January 2018

A Role for p38MAPK/HSP27 Pathway in Smooth Muscle Cell Migration

1 reference

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21 January 2018

Chemotactic peptide N-formyl-met-leu-phe activation of p38 mitogen-activated protein kinase (MAPK) and MAPK-activated protein kinase-2 in human neutrophils

1 reference

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21 January 2018

Requirement for phosphoinositide 3-OH kinase in growth hormone signalling to the mitogen-activated protein kinase and p70s6k pathways

1 reference

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21 January 2018

MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates

1 reference

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21 January 2018

Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

1 reference

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21 January 2018

Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27.

1 reference

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21 January 2018

3pK, a novel mitogen-activated protein (MAP) kinase-activated protein kinase, is targeted by three MAP kinase pathways

1 reference

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21 January 2018

Identifiers

10.1074/JBC.275.3.2103

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10636915%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10636915%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

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