The yeast homeodomain protein MATalpha2 shows extended DNA binding specificity in complex with Mcm1 (Q73174600)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9079665%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

title

The yeast homeodomain protein MATalpha2 shows extended DNA binding specificity in complex with Mcm1 (English)

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1 November 2019

author name string

H Zhong

series ordinal

1

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1 November 2019

A K Vershon

series ordinal

2

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1 November 2019

language of work or name

English

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publication date

1 March 1997

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Journal of Biological Chemistry

1 November 2019

published in

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1 November 2019

volume

272

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1 November 2019

page(s)

8402-8409

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1 November 2019

issue

13

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1 November 2019

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Yeast a1 and alpha 2 homeodomain proteins form a DNA-binding activity with properties distinct from those of either protein

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The yeast cell-type-specific repressor alpha 2 acts cooperatively with a non-cell-type-specific protein.

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Yeast repressor alpha 2 binds to its operator cooperatively with yeast protein Mcm1.

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A protein involved in minichromosome maintenance in yeast binds a transcriptional enhancer conserved in eukaryotes

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Sequences upstream of the STE6 gene required for its expression and regulation by the mating type locus in Saccharomyces cerevisiae

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Flexibility of the yeast alpha 2 repressor enables it to occupy the ends of its operator, leaving the center free

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A molecular mechanism for combinatorial control in yeast: MCM1 protein sets the spacing and orientation of the homeodomains of an alpha 2 dimer

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Homeo domain of the yeast repressor alpha 2 is a sequence-specific DNA-binding domain but is not sufficient for repression

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The WD repeats of Tup1 interact with the homeo domain protein alpha 2.

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A short, disordered protein region mediates interactions between the homeodomain of the yeast alpha 2 protein and the MCM1 protein

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The carboxy-terminal tail of the homeo domain protein alpha 2 is required for function with a second homeo domain protein.

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Crystal structure of the MATa1/MAT alpha 2 homeodomain heterodimer bound to DNA

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Secondary structure of the homeo domain of yeast alpha 2 repressor determined by NMR spectroscopy

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Identifiers

DOI

10.1074/JBC.272.13.8402

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9079665%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

1 reference