RB transcriptional corepressor like 2 (Q7316792)

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mammalian protein found in Homo sapiens

• PRB2
• 130 kDa retinoblastoma-associated protein
• retinoblastoma-like 2
• retinoblastoma-like protein 2
• retinoblastoma-related protein 2
• p130
• RBR-2
• RBL2

edit

Language	Label	Description	Also known as
English	RB transcriptional corepressor like 2	mammalian protein found in Homo sapiens	PRB2 130 kDa retinoblastoma-associated protein retinoblastoma-like 2 retinoblastoma-like protein 2 retinoblastoma-related protein 2 p130 RBR-2 RBL2

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q08999

part of

Cyclin-like superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q08999

Retinoblastoma-like protein 2

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q08999

Cyclin-like, protein family

1 reference

based on heuristic

inferred from protein domain or family

Retinoblastoma-associated protein, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Retinoblastoma-associated protein, B-box family

1 reference

based on heuristic

inferred from protein domain or family

Retinoblastoma-associated protein, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Retinoblastoma-associated protein, A-box family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q08999

encoded by

RBL2

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q08999

molecular function

DNA binding

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q08999

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08999

determination method

IEA

protein binding

determination method

IPI

12 references

retrieved

8 April 2019

stated in

Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence

GOA

curator

UniProt

UniProt protein ID

Q08999

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08999

determination method

IPI

retrieved

8 April 2019

stated in

The retinoblastoma family proteins bind to and activate diacylglycerol kinase zeta

GOA

curator

UniProt

UniProt protein ID

Q08999

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08999

determination method

IPI

retrieved

8 April 2019

stated in

Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08999

determination method

IPI

retrieved

8 April 2019

stated in

A dynamic equilibrium between CDKs and PP2A modulates phosphorylation of pRB, p107 and p130

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08999

determination method

IPI

retrieved

8 April 2019

stated in

LIN54 is an essential core subunit of the DREAM/LINC complex that binds to the cdc2 promoter in a sequence-specific manner

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08999

determination method

IPI

retrieved

8 April 2019

stated in

Interaction of the pRB-family proteins with factors containing paired-like homeodomains

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08999

determination method

IPI

retrieved

8 April 2019

stated in

Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130.

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08999

determination method

IPI

retrieved

8 April 2019

stated in

Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08999

determination method

IPI

retrieved

8 April 2019

stated in

Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08999

determination method

IPI

retrieved

8 April 2019

stated in

The retinoblastoma family proteins bind to and activate diacylglycerol kinase zeta

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08999

determination method

IPI

retrieved

8 April 2019

stated in

Pooled-matrix protein interaction screens using Barcode Fusion Genetics

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08999

determination method

IPI

retrieved

8 April 2019

stated in

Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08999

determination method

IPI

promoter-specific chromatin binding

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Post-transcriptional gene expression control by NANOS is up-regulated and functionally important in pRb-deficient cells

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08999

determination method

IDA

DNA-binding transcription repressor activity, RNA polymerase II-specific

determination method

IBA

1 reference

retrieved

1 January 2018

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08999&geneProductId=UniProtKB:Q08999

determination method

IBA

cell component

nucleolus

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08999

determination method

IDA

extracellular exosome

determination method

IDA

1 reference

retrieved

17 October 2017

stated in

Large-scale proteomics and phosphoproteomics of urinary exosomes

GOA

curator

UniProt

UniProt protein ID

Q08999

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08999&geneProductId=UniProtKB:Q08999

determination method

IDA

nucleus

determination method

IDA

IEA

4 references

retrieved

17 October 2017

stated in

GOA

curator

UniProt

UniProt protein ID

Q08999

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08999&geneProductId=UniProtKB:Q08999

determination method

IEA

retrieved

17 October 2017

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08999&geneProductId=UniProtKB:Q08999

determination method

IEA

retrieved

17 October 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08999&geneProductId=UniProtKB:Q08999

determination method

IEA

retrieved

17 October 2017

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08999&geneProductId=UniProtKB:Q08999

determination method

IDA

transcription regulator complex

determination method

IEA

2 references

retrieved

17 October 2017

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08999&geneProductId=UniProtKB:Q08999

determination method

IEA

retrieved

17 October 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08999&geneProductId=UniProtKB:Q08999

determination method

IEA

nucleoplasm

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08999

determination method

TAS

cytosol

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08999

determination method

IDA

chromatin

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08999

determination method

IBA

nucleus

determination method

IBA

IDA

IEA

5 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q08999

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08999

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08999

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08999

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08999

determination method

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08999

determination method

IBA

transcription regulator complex

determination method

IBA

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08999

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08999

determination method

IEA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08999

determination method

IBA

extracellular exosome

determination method

HDA

1 reference

retrieved

8 April 2019

stated in

Large-scale proteomics and phosphoproteomics of urinary exosomes

GOA

curator

UniProt

UniProt protein ID

Q08999

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08999

determination method

HDA

biological process

regulation of transcription by RNA polymerase II

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08999

determination method

IEA

regulation of cell cycle

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08999

determination method

IEA

cell cycle

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q08999

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08999

determination method

IEA

regulation of transcription, DNA-templated

determination method

IEA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

UniProt

UniProt protein ID

Q08999

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08999&geneProductId=UniProtKB:Q08999

determination method

IEA

transcription, DNA-templated

determination method

IEA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

UniProt

UniProt protein ID

Q08999

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08999&geneProductId=UniProtKB:Q08999

determination method

IEA

regulation of lipid kinase activity

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

The retinoblastoma family proteins bind to and activate diacylglycerol kinase zeta

GOA

curator

UniProt

UniProt protein ID

Q08999

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08999

determination method

IDA

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08999

determination method

TAS

negative regulation of gene expression

determination method

IMP

1 reference

retrieved

8 April 2019

stated in

Post-transcriptional gene expression control by NANOS is up-regulated and functionally important in pRb-deficient cells

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08999

determination method

IMP

negative regulation of transcription by RNA polymerase II

determination method

IEA

1 reference

retrieved

1 January 2018

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08999&geneProductId=UniProtKB:Q08999

determination method

IEA

chromatin organization

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q08999

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08999

determination method

IEA

regulation of mitotic cell cycle

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08999

determination method

IBA

cell differentiation

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08999

determination method

IBA

regulation of cell division

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08999

determination method

IEA

negative regulation of G1/S transition of mitotic cell cycle

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08999

determination method

IBA

Gene Atlas image

PBB GE RBL2 212331 at fs.png
732 × 530; 11 KB

0 references

exact match

https://identifiers.org/uniprot:Q08999

1 reference

stated in

Identifiers.org

UniProt protein ID

Q08999

reference URL

https://registry.identifiers.org/registry/uniprot

http://purl.uniprot.org/uniprot/Q08999

1 reference

stated in

Identifiers.org

UniProt protein ID

Q08999

reference URL

https://registry.identifiers.org/registry/uniprot

https://www.ncbi.nlm.nih.gov/protein/Q08999

1 reference

stated in

Identifiers.org

UniProt protein ID

Q08999

reference URL

https://registry.identifiers.org/registry/uniprot

has part(s)

Retinoblastoma-associated protein, N-terminal

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q08999

Cyclin-like

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q08999

Retinoblastoma-associated protein, C-terminal

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q08999

Retinoblastoma-associated protein, A-box

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q08999

Retinoblastoma-associated protein, B-box

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q08999

Identifiers

MeSH descriptor ID

D050717

0 references

RefSeq protein ID

NP_001310537

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

5934

NP_001310538

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

5934

NP_001310539

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

5934

NP_001310540

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

5934

NP_005602

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

5934

XP_011521555

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

5934

XP_016879002

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

5934

UniProt protein ID

Q08999

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q08999

Ensembl protein ID

ENSP00000262133

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000262133

ENSP00000443744

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000443744

ENSP00000462464

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000462464

PDB structure ID

4XI9

1 reference

stated in

UniProt

UniProt protein ID

Q08999

retrieved

5 August 2016

language of work or name

English

5C1D

1 reference

stated in

UniProt

UniProt protein ID

Q08999

retrieved

5 August 2016

language of work or name

English

UMLS CUI

C1529719

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

stated in

UMLS 2023

retrieved

25 May 2023

 

Sitelinks

Wikipedia(0 entries)

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Wikibooks(0 entries)

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Wikinews(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

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Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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Retrieved from "https://www.wikidata.org/w/index.php?title=Q7316792&oldid=2022910049"