Design of a potent and orally active nonpeptide platelet fibrinogen receptor (GPIIb/IIIa) antagonist (Q72145456)

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24 October 2019

title

Design of a potent and orally active nonpeptide platelet fibrinogen receptor (GPIIb/IIIa) antagonist (English)

1 reference

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24 October 2019

author name string

W E Bondinell

1

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24 October 2019

R M Keenan

2

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24 October 2019

W H Miller

3

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24 October 2019

F E Ali

4

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24 October 2019

A C Allen

5

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24 October 2019

C W de Brosse

6

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24 October 2019

D S Eggleston

7

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24 October 2019

K F Erhard

8

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24 October 2019

R C Haltiwanger

9

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24 October 2019

W F Huffman

10

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24 October 2019

language of work or name

English

0 references

publication date

1 September 1994

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Bioorganic & Medicinal Chemistry

24 October 2019

published in

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24 October 2019

volume

2

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24 October 2019

issue

9

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24 October 2019

page(s)

897-908

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Development of GPIIb/IIIa antagonists as antithrombotic drugs

24 October 2019

cites work

1 reference

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7 January 2021

Platelet receptor recognition site on human fibrinogen. Synthesis and structure-function relationship of peptides corresponding to the carboxy-terminal segment of the .gamma. chain

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Platelet receptor recognition domain on the gamma chain of human fibrinogen and its synthetic peptide analogues

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Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule

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Recognition of distinct adhesive sites on fibrinogen by related integrins on platelets and endothelial cells.

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Development of a small RGD peptide fibrinogen receptor antagonist with potent antiaggregatory activity in vitro

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7 January 2021

Conformationally constrained peptides and semipeptides derived from RGD as potent inhibitors of the platelet fibrinogen receptor and platelet aggregation

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7 January 2021

The in vitro pharmacological profile of SK&F 106760, a novel GPIIB/IIIA antagonist

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7 January 2021

Low molecular weight, non-peptide fibrinogen receptor antagonists

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The influence of peptide structure on transport across Caco-2 cells

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Desolvation energy: a major determinant of absorption, but not clearance, of peptides in rats

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7 January 2021

The influence of peptide structure on transport across Caco-2 cells. II. Peptide bond modification which results in improved permeability

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7 January 2021

Design and synthesis of peptidomimetic inhibitors of HIV-1 protease and renin. Evidence for improved transport

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7 January 2021

Development of a new physicochemical model for brain penetration and its application to the design of centrally acting H2 receptor histamine antagonists

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7 January 2021

Practical approach to solid-phase synthesis of C-terminal peptide amides under mild conditions based on a photolysable anchoring linkage

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7 January 2021

Swelling and dissolution kinetics during peptide release from erodible anionic gel beads

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7 January 2021

Evaluation of mannitol for use as a probe marker of gastrointestinal permeability in man.

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7 January 2021

Pharmacokinetic profile of diazepam in man following single intravenous and oral and chronic oral administrations.

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Significance tests on the crystallographic R factor

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7 January 2021

Intestinal 5-fluorouracil absorption: use of Ussing chambers to assess transport and metabolism

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7 January 2021

10.1016/S0968-0896(00)82039-8

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7712125%20AND%20SRC:MED&resulttype=core&format=json

24 October 2019

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