Tamoxifen metabolism by microsomal cytochrome P450 and flavin-containing monooxygenase (Q71497736)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8791773%20AND%20SRC:MED&resulttype=core&format=json

19 October 2019

title

Tamoxifen metabolism by microsomal cytochrome P450 and flavin-containing monooxygenase (English)

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19 October 2019

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D Kupfer

1

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19 October 2019

S S Dehal

series ordinal

2

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19 October 2019

publication date

1 January 1996

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19 October 2019

published in

Methods in Enzymology

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19 October 2019

volume

272

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19 October 2019

page(s)

152-163

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The development of tamoxifen for breast cancer therapy: a tribute to the late Arthur L. Walpole

19 October 2019

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New Perspective on Cancer of the Contralateral Breast: A Marker for Assessing Tamoxifen as a Preventive Agent

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Adjuvant tamoxifen in early breast cancer: occurrence of new primary cancers

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Non-linearity of neoplastic conversion induced in rat liver by low exposures to diethylnitrosamine

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Metabolism of tamoxifen by rat liver microsomes: formation of the N-oxide, a new metabolite

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7 January 2021

Aspects of metabolism of tamoxifen by rat liver microsomes. Identification of a new metabolite: E-1-[4-(2-dimethylaminoethoxy)-phenyl]-1, 2-diphenyl-1-buten-3-ol N-oxide

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A comparative study of tamoxifen metabolism in female rat, mouse and human liver microsomes.

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The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature

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Identification of the cytochrome P450 IIIA family as the enzymes involved in the N-demethylation of tamoxifen in human liver microsomes

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Genotoxic potential of tamoxifen and analogues in female Fischer F344/n rats, DBA/2 and C57BL/6 mice and in human MCL-5 cells

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Microsomal and peroxidase activation of 4-hydroxy-tamoxifen to form DNA adducts: comparison with DNA adducts formed in Sprague-Dawley rats treated with tamoxifen.

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Involvement of cytochrome P4503A in catalysis of tamoxifen activation and covalent binding to rat and human liver microsomes.

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Induction of CYP2B1 and 3A1, and associated monoxygenase activities by tamoxifen and certain analogues in the livers of female rats and mice.

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A linear standard curve for the Folin Lowry determination of protein

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Covalent binding of [14C]methoxychlor metabolite(s) to rat liver microsomal components.

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Variations in catechol O-methyltransferase activity in rodent tissues: possible role in estrogen carcinogenicity.

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Estrogen-2-hydroxylase in the rat. Distribution and response to hormonal manipulation

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Metabolism of methoxychlor by hepatic P-450 monooxygenases in rat and human. 1. Characterization of a novel catechol metabolite.

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Identification of the cytochrome P-450 induced by macrolide antibiotics in rat liver as the glucocorticoid responsive cytochrome P-450p

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7 January 2021

Regulation of testosterone hydroxylation by rat liver microsomal cytochrome P-450.

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Reconstitution of testosterone oxidation by purified rat cytochrome P450p (IIIA1)

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7 January 2021

Antiestrogens inhibit the mitogenic effect of growth factors on breast cancer cells in the total absence of estrogens

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7 January 2021

Species differences in the covalent binding of [14C]tamoxifen to liver microsomes and the forms of cytochrome P450 involved

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Reduction of tertiary amine N-oxide by purified cytochrome P-450

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Reduced nicotinamide adenine dinucleotide-dependent reduction of tertiary amine N-oxide by liver microsomal cytochrome P-450

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7 January 2021

10.1016/S0076-6879(96)72019-0

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8791773%20AND%20SRC:MED&resulttype=core&format=json

19 October 2019

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