MYH9: Structure, functions and role of non-muscle myosin IIA in human disease. (Q65950270)

26 July 2019

review article

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title

MYH9: Structure, functions and role of non-muscle myosin IIA in human disease. (English)

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26 July 2019

part of the series

Gene Wiki Review Series

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author

Anna Savoia

3

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26 July 2019

author name string

Alessandro Pecci

1

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26 July 2019

Xuefei Ma

2

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26 July 2019

Robert S Adelstein

4

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26 July 2019

language of work or name

English

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publication date

19 April 2018

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26 July 2019

published in

Gene

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26 July 2019

volume

664

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26 July 2019

page(s)

152-167

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26 July 2019

Phosphorylation of platelet myosin increases actin-activated myosin ATPase activity

cites work

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Chicken nonmuscle myosin heavy chains: differential expression of two mRNAs and evidence for two different polypeptides

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Phosphorylation of bovine platelet myosin by protein kinase C.

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In situ phosphorylation of human platelet myosin heavy and light chains by protein kinase C

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Fechtner syndrome--a variant of Alport's syndrome with leukocyte inclusions and macrothrombocytopenia

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Reversible phosphorylation of smooth muscle myosin, heavy meromyosin, and platelet myosin

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Protein kinase C modulates in vitro phosphorylation of the smooth muscle heavy meromyosin by myosin light chain kinase

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Light-chain phosphorylation controls the conformation of vertebrate non-muscle and smooth muscle myosin molecules

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Phosphorylation of vertebrate nonmuscle and smooth muscle myosin heavy chains and light chains

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Fechtner syndrome: report of a third family and literature review

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Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes

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Visualization of head-head interactions in the inhibited state of smooth muscle myosin

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Myosins: a diverse superfamily

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12 December 2020

Distinct roles of ROCK (Rho-kinase) and MLCK in spatial regulation of MLC phosphorylation for assembly of stress fibers and focal adhesions in 3T3 fibroblasts.

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12 December 2020

Mutations in MYH9 result in the May-Hegglin anomaly, and Fechtner and Sebastian syndromes. The May-Heggllin/Fechtner Syndrome Consortium

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12 December 2020

Mutation of MYH9, encoding non-muscle myosin heavy chain A, in May-Hegglin anomaly.

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12 December 2020

Human nonsyndromic hereditary deafness DFNA17 is due to a mutation in nonmuscle myosin MYH9

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12 December 2020

Mutations in the NMMHC-A gene cause autosomal dominant macrothrombocytopenia with leukocyte inclusions (May-Hegglin anomaly/Sebastian syndrome).

1 reference

12 December 2020

Cloning of the murine non-muscle myosin heavy chain IIA gene ortholog of human MYH9 responsible for May-Hegglin, Sebastian, Fechtner, and Epstein syndromes

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12 December 2020

Mutations in human nonmuscle myosin IIA found in patients with May-Hegglin anomaly and Fechtner syndrome result in impaired enzymatic function

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12 December 2020

Immunofluorescence analysis of neutrophil nonmuscle myosin heavy chain-A in MYH9 disorders: association of subcellular localization with MYH9 mutations.

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12 December 2020

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12 December 2020

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12 December 2020

Ablation and mutation of nonmuscle myosin heavy chain II-B results in a defect in cardiac myocyte cytokinesis

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12 December 2020

Identification and characterization of nonmuscle myosin II-C, a new member of the myosin II family

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12 December 2020

Correlation between the clinical phenotype of MYH9-related disease and tissue distribution of class II nonmuscle myosin heavy chains

1 reference

12 December 2020

Defects in cell adhesion and the visceral endoderm following ablation of nonmuscle myosin heavy chain II-A in mice

1 reference

12 December 2020

First description of somatic mosaicism in MYH9 disorders

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12 December 2020

Disease-associated mutations and alternative splicing alter the enzymatic and motile activity of nonmuscle myosins II-B and II-C

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12 December 2020

Suppression of tumor development and metastasis formation in mice lacking the S100A4(mts1) gene

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12 December 2020

Genotype-phenotype correlation in MYH9-related thrombocytopenia

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12 December 2020

New insights into myosin evolution and classification

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12 December 2020

The S100A4 Metastasis Factor Regulates Cellular Motility via a Direct Interaction with Myosin-IIA

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12 December 2020

Phosphorylation of nonmuscle myosin heavy chain IIA on Ser1917 is mediated by protein kinase C beta II and coincides with the onset of stimulated degranulation of RBL-2H3 mast cells

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12 December 2020

Branching morphogenesis during development of placental villi

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12 December 2020

A product of their environment: do megakaryocytes rely on extracellular cues for proplatelet formation?

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12 December 2020

Haematological characteristics of MYH9 disorders due to MYH9 R702 mutations

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12 December 2020

The May-Hegglin anomaly gene MYH9 is a negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway

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12 December 2020

Myosin II isoforms in smooth muscle: heterogeneity and function

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12 December 2020

Myosin-IIA heavy-chain phosphorylation regulates the motility of MDA-MB-231 carcinoma cells

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12 December 2020

Structures of smooth muscle myosin and heavy meromyosin in the folded, shutdown state.

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12 December 2020

Drawing the tree of eukaryotic life based on the analysis of 2,269 manually annotated myosins from 328 species

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12 December 2020

The phosphorylation of myosin II at the Ser1 and Ser2 is critical for normal platelet-derived growth factor induced reorganization of myosin filaments

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12 December 2020

Position of nonmuscle myosin heavy chain IIA (NMMHC-IIA) mutations predicts the natural history of MYH9-related disease

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12 December 2020

TRPM7 regulates myosin IIA filament stability and protein localization by heavy chain phosphorylation

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12 December 2020

Head-head and head-tail interaction: a general mechanism for switching off myosin II activity in cells

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12 December 2020

Renin-angiotensin system blockade is effective in reducing proteinuria of patients with progressive nephropathy caused by MYH9 mutations (Fechtner-Epstein syndrome).

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12 December 2020

The alpha-kinases TRPM6 and TRPM7, but not eEF-2 kinase, phosphorylate the assembly domain of myosin IIA, IIB and IIC.

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12 December 2020

Adhesive receptors, extracellular proteins and myosin IIA orchestrate proplatelet formation by human megakaryocytes.

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12 December 2020

MYH9 is associated with nondiabetic end-stage renal disease in African Americans

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12 December 2020

MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis

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12 December 2020

The C-terminal tail region of nonmuscle myosin II directs isoform-specific distribution in migrating cells

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12 December 2020

Germinal mosaicism in MYH9 disorders: a family with two affected siblings of normal parents.

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12 December 2020

Identification of the first duplication in MYH9-related disease: a hot spot for unequal crossing-over within exon 24 of the MYH9 gene

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12 December 2020

Identification of three in-frame deletion mutations in MYH9 disorders suggesting an important hot spot for small rearrangements in MYH9 exon 24.

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12 December 2020

Megakaryocytes of patients with MYH9-related thrombocytopenia present an altered proplatelet formation

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12 December 2020

Non-muscle myosin II takes centre stage in cell adhesion and migration

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12 December 2020

Megakaryocyte and platelet abnormalities in a patient with a W33C mutation in the conserved SH3-like domain of myosin heavy chain IIA.

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12 December 2020

Heavy chain myosin 9-related disease (MYH9 -RD): neutrophil inclusions of myosin-9 as a pathognomonic sign of the disorder.

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12 December 2020

Patients with Epstein-Fechtner syndromes owing to MYH9 R702 mutations develop progressive proteinuric renal disease

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12 December 2020

S100A4 regulates macrophage chemotaxis

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12 December 2020

Glomerular pathology in autosomal dominant MYH9 spectrum disorders: what are the clues telling us about disease mechanism?

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12 December 2020

Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene

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12 December 2020

Association of trypanolytic ApoL1 variants with kidney disease in African Americans

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12 December 2020

Nonmuscle myosin II isoform and domain specificity during early mouse development

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12 December 2020

Eltrombopag for the treatment of the inherited thrombocytopenia deriving from MYH9 mutations

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12 December 2020

Ablation of nonmuscle myosin II-B and II-C reveals a role for nonmuscle myosin II in cardiac myocyte karyokinesis

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12 December 2020

Direct evidence for functional smooth muscle myosin II in the 10S self-inhibited monomeric conformation in airway smooth muscle cells

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12 December 2020

Renal manifestations of patients with MYH9-related disorders

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12 December 2020

Polymorphisms in the nonmuscle myosin heavy chain 9 gene (MYH9) are associated with the progression of IgA nephropathy in Chinese

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12 December 2020

The MYH9/APOL1 region and chronic kidney disease in European-Americans

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12 December 2020

Mutations responsible for MYH9-related thrombocytopenia impair SDF-1-driven migration of megakaryoblastic cells

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12 December 2020

Mouse models of MYH9-related disease: mutations in nonmuscle myosin II-A.

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12 December 2020

Polymorphisms in MYH9 are associated with diabetic nephropathy in European Americans

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12 December 2020

APOL1 genetic variants in focal segmental glomerulosclerosis and HIV-associated nephropathy

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12 December 2020

Myosin II isoform switching mediates invasiveness after TGF-β-induced epithelial-mesenchymal transition

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12 December 2020

Analysis of the role of Ser1/Ser2/Thr9 phosphorylation on myosin II assembly and function in live cells

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12 December 2020

The role of non-muscle myosin IIA in aggregation and invasion of human MCF-7 breast cancer cells.

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12 December 2020

In vivo studies on nonmuscle myosin II expression and function in heart development

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12 December 2020

Short-term eltrombopag for surgical preparation of a patient with inherited thrombocytopenia deriving from MYH9 mutation

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12 December 2020

Crystal structure of the S100A4-nonmuscle myosin IIA tail fragment complex reveals an asymmetric target binding mechanism

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12 December 2020

Alteration of liver enzymes is a feature of the MYH9-related disease syndrome.

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12 December 2020

Nonmuscle myosin-2: mix and match

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12 December 2020

Microtubule and cortical forces determine platelet size during vascular platelet production

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12 December 2020

Does size matter in platelet production?

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12 December 2020

Platelets: production, morphology and ultrastructure

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12 December 2020

MYBPH inhibits NM IIA assembly via direct interaction with NMHC IIA and reduces cell motility

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12 December 2020

Crawling from soft to stiff matrix polarizes the cytoskeleton and phosphoregulates myosin-II heavy chain

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12 December 2020

Diagnosis and management of inherited thrombocytopenias

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12 December 2020

Application of massively parallel sequencing to genetic diagnosis in multiplex families with idiopathic sensorineural hearing impairment

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12 December 2020

NMII forms a contractile transcellular sarcomeric network to regulate apical cell junctions and tissue geometry

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12 December 2020

Platelet size for distinguishing between inherited thrombocytopenias and immune thrombocytopenia: a multicentric, real life study

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12 December 2020

Keratin 5-Cre-driven excision of nonmuscle myosin IIA in early embryo trophectoderm leads to placenta defects and embryonic lethality.

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12 December 2020

Apparent genotype–phenotype mismatch in a patient with MYH9-related disease: When the exception proves the rule

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12 December 2020

First successful use of eltrombopag before surgery in a child with MYH9-related thrombocytopenia

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12 December 2020

Targeted exon sequencing successfully discovers rare causative genes and clarifies the molecular epidemiology of Japanese deafness patients.

1 reference

12 December 2020

Establishment of mouse model of MYH9 disorders: heterozygous R702C mutation provokes macrothrombocytopenia with leukocyte inclusion bodies, renal glomerulosclerosis and hearing disability

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12 December 2020

The heavy chain has its day: regulation of myosin-II assembly

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12 December 2020

Normal neutrophil myosin IIA localization in an immunofluorescence analysis can rule out MYH9 disorders.

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12 December 2020

A Post-Hoc Comparison of the Utility of Sanger Sequencing and Exome Sequencing for the Diagnosis of Heterogeneous Diseases

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12 December 2020

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12 December 2020

The tumor suppressor Lgl1 forms discrete complexes with NMII-A and Par6α-aPKCζ that are affected by Lgl1 phosphorylation

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12 December 2020

Structure of the S100A4/myosin-IIA complex

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12 December 2020

Direct in vivo RNAi screen unveils myosin IIa as a tumor suppressor of squamous cell carcinomas

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12 December 2020

Evolution and classification of myosins, a paneukaryotic whole-genome approach

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12 December 2020

Somatic mosaicism in MYH9 disorders: the need to carefully evaluate apparently healthy parents.

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12 December 2020

Nonmuscle myosin II isoforms coassemble in living cells

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12 December 2020

R705H mutation of MYH9 is associated with MYH9-related disease and not only with non-syndromic deafness DFNA17.

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12 December 2020

Cochlear implantation is safe and effective in patients with MYH9-related disease

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12 December 2020

Platelet diameters in inherited thrombocytopenias: analysis of 376 patients with all known disorders

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12 December 2020

Mutation spectrum and genotype-phenotype correlations in a large French cohort of MYH9-Related Disorders

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12 December 2020

The role of vertebrate nonmuscle Myosin II in development and human disease

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12 December 2020

Endogenous species of mammalian nonmuscle myosin IIA and IIB include activated monomers and heteropolymers.

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12 December 2020

The tumor suppressor Lgl1 regulates front-rear polarity of migrating cells

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12 December 2020

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12 December 2020

S100 proteins in cancer

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12 December 2020

Myosin II isoform co-assembly and differential regulation in mammalian systems

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12 December 2020

Distinct localizations and roles of non-muscle myosin II during proplatelet formation and platelet release

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12 December 2020

Myosin 18A coassembles with nonmuscle myosin 2 to form mixed bipolar filaments

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12 December 2020

Prognostic significance of MYH9 expression in resected non-small cell lung cancer

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12 December 2020

A novel MYH9 mutation in a patient with MYH9 disorders and platelet size-specific effect of romiplostim on macrothrombocytopenia.

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12 December 2020

Nonmuscle Myosin Heavy Chain IIA Mutation Predicts Severity and Progression of Sensorineural Hearing Loss in Patients With MYH9-Related Disease

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12 December 2020

Conditional deletion of nonmuscle myosin II-A in mouse tongue epithelium results in squamous cell carcinoma

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12 December 2020

Load-dependent modulation of non-muscle myosin-2A function by tropomyosin 4.2.

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12 December 2020

Kinetic Adaptations of Myosins for Their Diverse Cellular Functions

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12 December 2020

Comprehensive genetic testing in the clinical evaluation of 1119 patients with hearing loss

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12 December 2020

Genetic association of MYH genes with hereditary hearing loss in Korea.

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12 December 2020

Local pulsatile contractions are an intrinsic property of the myosin 2A motor in the cortical cytoskeleton of adherent cells

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12 December 2020

Myosin IIA Heavy Chain Phosphorylation Mediates Adhesion Maturation and Protrusion in Three Dimensions

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12 December 2020

Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice

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12 December 2020

LIMCH1 regulates nonmuscle myosin-II activity and suppresses cell migration

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12 December 2020

Diagnosis of inherited platelet disorders on a blood smear: a tool to facilitate worldwide diagnosis of platelet disorders.

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12 December 2020

Insertional mutagenesis identifies drivers of a novel oncogenic pathway in invasive lobular breast carcinoma.

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12 December 2020

LIM kinase 1 interacts with myosin-9 and alpha-actinin-4 and promotes colorectal cancer progression.

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12 December 2020

Self-sorting of nonmuscle myosins IIA and IIB polarizes the cytoskeleton and modulates cell motility.

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12 December 2020

Eltrombopag to Treat Thrombocytopenia During Last Month of Pregnancy in a Woman With MYH9-Related Disease: A Case Report

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12 December 2020

MYBPH inhibits vascular smooth muscle cell migration and attenuates neointimal hyperplasia in a rat carotid balloon-injury model.

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12 December 2020

MicroRNA-647 Targets SRF-MYH9 Axis to Suppress Invasion and Metastasis of Gastric Cancer

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12 December 2020

MYH9 E1841K Mutation Augments Proteinuria and Podocyte Injury and Migration

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12 December 2020

Activation of ROCK and MLCK tunes regional stress fiber formation and mechanics via preferential myosin light chain phosphorylation

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12 December 2020

10.1016/J.GENE.2018.04.048

Identifiers

DOI

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26 July 2019

PMCID

5970098

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26 July 2019

PubMed ID

29679756

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26 July 2019