Lamin B receptor (Q6481869)

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mammalian protein found in Homo sapiens

C-14 sterol reductase
LBR
sterol C14-reductase
lamin-B receptor
delta-14-SR
delta(14)-sterol reductase LBR
tudor domain containing 18
3-beta-hydroxysterol Delta (14)-reductase
delta(14)-sterol reductase
integral nuclear envelope inner membrane protein
LMN2R
Lamin-B receptor

Language	Label	Description	Also known as
English	Lamin B receptor	mammalian protein found in Homo sapiens	C-14 sterol reductase LBR sterol C14-reductase lamin-B receptor delta-14-SR delta(14)-sterol reductase LBR tudor domain containing 18 3-beta-hydroxysterol Delta (14)-reductase delta(14)-sterol reductase integral nuclear envelope inner membrane protein LMN2R Lamin-B receptor

Statements

1 reference

13 November 2019

UniProt protein ID

Ergosterol biosynthesis ERG4/ERG24

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q14739

Tudor domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Sterol reductase, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Lamin-B receptor of TUDOR domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

2 references

13 November 2019

UniProt protein ID

UniProt protein ID

17 September 2016

2 references

13 November 2019

UniProt protein ID

UniProt protein ID

30 June 2016

language of work or name

molecular function

oxidoreductase activity, acting on the CH-CH group of donors

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14739&geneProductId=UniProtKB:Q14739

determination method

oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14739

determination method

protein binding

determination method

chromo shadow domain binding

determination method

1 reference

8 April 2019

The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14739

determination method

determination method

1 reference

8 April 2019

Primary structure analysis and lamin B and DNA binding of human LBR, an integral protein of the nuclear envelope inner membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14739

determination method

delta14-sterol reductase activity

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14739&geneProductId=UniProtKB:Q14739

determination method

determination method

1 reference

26 September 2017

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14739&geneProductId=UniProtKB:Q14739

determination method

determination method

1 reference

8 April 2019

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14739

determination method

delta14-sterol reductase activity

determination method

8 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14739

determination method

8 April 2019

The Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutations

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14739

determination method

8 April 2019

Autosomal recessive HEM/Greenberg skeletal dysplasia is caused by 3 beta-hydroxysterol delta 14-reductase deficiency due to mutations in the lamin B receptor gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14739

determination method

8 April 2019

Mutations causing Greenberg dysplasia but not Pelger anomaly uncouple enzymatic from structural functions of a nuclear membrane protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14739

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14739

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14739

determination method

8 April 2019

Human lamin B receptor exhibits sterol C14-reductase activity in Saccharomyces cerevisiae.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14739

determination method

8 April 2019

Sterol dependent regulation of human TM7SF2 gene expression: role of the encoded 3beta-hydroxysterol Delta14-reductase in human cholesterol biosynthesis.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14739

determination method

determination method

1 reference

8 April 2019

The Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutations

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14739

determination method

oxidoreductase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14739

determination method

integral component of endoplasmic reticulum membrane

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14739&geneProductId=UniProtKB:Q14739

determination method

nuclear inner membrane

determination method

1 reference

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14739&geneProductId=UniProtKB:Q14739

determination method

integral component of nuclear inner membrane

determination method

1 reference

8 April 2019

Primary structure analysis and lamin B and DNA binding of human LBR, an integral protein of the nuclear envelope inner membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14739

determination method

determination method

3 references

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14739&geneProductId=UniProtKB:Q14739

determination method

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14739&geneProductId=UniProtKB:Q14739

determination method

26 September 2017

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14739&geneProductId=UniProtKB:Q14739

determination method

determination method

1 reference

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14739&geneProductId=UniProtKB:Q14739

determination method

determination method

1 reference

14 January 2019

Mutations causing Greenberg dysplasia but not Pelger anomaly uncouple enzymatic from structural functions of a nuclear membrane protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14739&geneProductId=UniProtKB:Q14739

determination method

endoplasmic reticulum membrane

determination method

1 reference

14 January 2019

Mutations causing Greenberg dysplasia but not Pelger anomaly uncouple enzymatic from structural functions of a nuclear membrane protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14739&geneProductId=UniProtKB:Q14739

determination method

determination method

endoplasmic reticulum

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14739

determination method

biological process

cholesterol biosynthetic process

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14739&geneProductId=UniProtKB:Q14739

determination method

sterol biosynthetic process

determination method

1 reference

14 January 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14739&geneProductId=UniProtKB:Q14739

determination method

cholesterol biosynthetic process

determination method

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14739

determination method

8 April 2019

The Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutations

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14739

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14739

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14739

determination method

8 April 2019

Sterol dependent regulation of human TM7SF2 gene expression: role of the encoded 3beta-hydroxysterol Delta14-reductase in human cholesterol biosynthesis.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14739

determination method

lipid metabolism

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14739

determination method

steroid biosynthetic process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14739

determination method

steroid metabolic process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14739

determination method

cholesterol metabolic process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14739

determination method

Gene Atlas image

PBB GE LBR 201795 at fs.png
732 × 530; 11 KB

0 references

Identifiers

MeSH descriptor ID

subject named as

Lamin B Receptor

0 references

D08.811.682.660.495

0 references

D12.776.826.187

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

1 reference

UniProt protein ID

30 June 2016

language of work or name

Ensembl protein ID

ENSP00000272163

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000272163

ENSP00000339883

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000339883

ENSP00000388059

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000388059

ENSP00000416554

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000416554

ENSP00000499114

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000499114

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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