An E460D substitution in the NS5 protein of tick-borne encephalitis virus confers resistance to the inhibitor Galidesivir (BCX4430) and also attenuates the virus for mice (Q64359221)

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scientific article published on 30 July 2019

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English	An E460D substitution in the NS5 protein of tick-borne encephalitis virus confers resistance to the inhibitor Galidesivir (BCX4430) and also attenuates the virus for mice	scientific article published on 30 July 2019

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scholarly article

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29 April 2020

An E460D Substitution in the NS5 Protein of Tick-Borne Encephalitis Virus Confers Resistance to the Inhibitor Galidesivir (BCX4430) and Also Attenuates the Virus for Mice (English)

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29 April 2020

tick-borne encephalitis

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tick-borne encephalitis virus

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Tick-Borne Encephalitis Virus

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Jean-Sélim Driouich

4

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29 April 2020

Xavier de Lamballerie

10

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Xavier de Lamballerie

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Ernest A. Gould

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Ernest A Gould

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Ludek Eyer

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ORCID Public Data File 2021

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Antoine Nougairède

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29 April 2020

Marie Uhlířová

3

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29 April 2020

Darina Zouharová

5

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James J Valdés

6

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Jan Haviernik

7

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publication date

30 July 2019

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Journal of Virology

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93

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29 April 2020

Pig kidney epithelial (PS) cells: a perfect tool for the study of flaviviruses and some other arboviruses

1 reference

https://pubmed.ncbi.nlm.nih.gov/31142664

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A simple micro-culture method for the study of group B arboviruses

1 reference

https://pubmed.ncbi.nlm.nih.gov/31142664

12 December 2020

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The molecular biology of tick-borne encephalitis virus. Review article.

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https://pubmed.ncbi.nlm.nih.gov/31142664

12 December 2020

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Attenuated virulence of pleconaril-resistant coxsackievirus B3 variants.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31142664

12 December 2020

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Tick‐Borne Encephalitis

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https://pubmed.ncbi.nlm.nih.gov/31142664

12 December 2020

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Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro

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https://pubmed.ncbi.nlm.nih.gov/31142664

12 December 2020

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[Isolation of new strains of meningoencephalitis virus in the Brno region during the summer of 1953]

1 reference

https://pubmed.ncbi.nlm.nih.gov/31142664

12 December 2020

based on heuristic

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Mutations in the NS2B and NS3 genes affect mouse neuroinvasiveness of a Western European field strain of tick-borne encephalitis virus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31142664

12 December 2020

based on heuristic

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Mechanism of antiviral drug resistance of vaccinia virus: identification of residues in the viral DNA polymerase conferring differential resistance to antipoxvirus drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/31142664

12 December 2020

based on heuristic

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Antiviral agents acting as DNA or RNA chain terminators

1 reference

https://pubmed.ncbi.nlm.nih.gov/31142664

12 December 2020

based on heuristic

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Tick-borne encephalitis: pathogenesis and clinical implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/31142664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment failure and resistance with direct-acting antiviral drugs against hepatitis C virus

1 reference

https://pubmed.ncbi.nlm.nih.gov/31142664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of mutational robustness in RNA virus evolution

1 reference

https://pubmed.ncbi.nlm.nih.gov/31142664

12 December 2020

based on heuristic

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Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31142664

12 December 2020

based on heuristic

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Inhibitors of the tick-borne, hemorrhagic fever-associated flaviviruses.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31142664

12 December 2020

based on heuristic

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Update on hepatitis C virus resistance to direct-acting antiviral agents

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https://pubmed.ncbi.nlm.nih.gov/31142664

12 December 2020

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Single-stranded positive-sense RNA viruses generated in days using infectious subgenomic amplicons

1 reference

https://pubmed.ncbi.nlm.nih.gov/31142664

12 December 2020

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BCX4430, a novel nucleoside analog, effectively treats yellow fever in a Hamster model

1 reference

https://pubmed.ncbi.nlm.nih.gov/31142664

12 December 2020

based on heuristic

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Nucleoside inhibitors of tick-borne encephalitis virus

1 reference

https://pubmed.ncbi.nlm.nih.gov/31142664

12 December 2020

based on heuristic

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"ISA-Lation" of Single-Stranded Positive-Sense RNA Viruses from Non-Infectious Clinical/Animal Samples

1 reference

https://pubmed.ncbi.nlm.nih.gov/31142664

12 December 2020

based on heuristic

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C-Nucleosides To Be Revisited

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https://pubmed.ncbi.nlm.nih.gov/31142664

12 December 2020

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The Attenuation Phenotype of a Ribavirin-Resistant Porcine Reproductive and Respiratory Syndrome Virus Is Maintained during Sequential Passages in Pigs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31142664

12 December 2020

based on heuristic

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BCX4430 - A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/31142664

12 December 2020

based on heuristic

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Structure-activity relationships of nucleoside analogues for inhibition of tick-borne encephalitis virus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31142664

12 December 2020

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Efficacy of the broad-spectrum antiviral compound BCX4430 against Zika virus in cell culture and in a mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/31142664

12 December 2020

based on heuristic

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Adenosine triphosphate analogs can efficiently inhibit the Zika virus RNA-dependent RNA polymerase

1 reference

https://pubmed.ncbi.nlm.nih.gov/31142664

12 December 2020

based on heuristic

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Purification of Zika virus RNA-dependent RNA polymerase and its use to identify small-molecule Zika inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/31142664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiviral activity of the adenosine analogue BCX4430 against West Nile virus and tick-borne flaviviruses

1 reference

https://pubmed.ncbi.nlm.nih.gov/31142664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural basis of Zika virus methyltransferase inhibition by sinefungin

1 reference

https://pubmed.ncbi.nlm.nih.gov/31142664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resistance Mechanisms in Hepatitis C Virus: implications for Direct-Acting Antiviral Use.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31142664

12 December 2020

based on heuristic

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Antiviral drug resistance as an adaptive process

1 reference

https://pubmed.ncbi.nlm.nih.gov/31142664

12 December 2020

based on heuristic

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Escape of tick-borne flavivirus from 2' -C-methylated nucleoside antivirals is mediated by a single conservative mutation in NS5 that has a dramatic effect on viral fitness

1 reference

https://pubmed.ncbi.nlm.nih.gov/31142664

12 December 2020

based on heuristic

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Nucleoside analogs as a rich source of antiviral agents active against arthropod-borne flaviviruses.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31142664

12 December 2020

based on heuristic

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SuPReMe: a rapid reverse genetics method to generate clonal populations of recombinant RNA viruses.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31142664

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based on heuristic

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Galidesivir limits Rift Valley fever virus infection and disease in Syrian golden hamsters

1 reference

https://pubmed.ncbi.nlm.nih.gov/31142664

12 December 2020

based on heuristic

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Differential Transmission of Antiviral Drug-Resistant Chikungunya Viruses by Mosquitoes

1 reference

https://pubmed.ncbi.nlm.nih.gov/31142664

12 December 2020

based on heuristic

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Tick-borne encephalitis in Europe and Russia: Review of pathogenesis, clinical features, therapy, and vaccines

1 reference

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12 December 2020

based on heuristic

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Identifiers

10.1128/JVI.00367-19

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Europe PubMed Central

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29 April 2020

1 reference

Europe PubMed Central

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29 April 2020

1 reference

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29 April 2020

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