Polyomavirus T Antigen Induces Expression Using an LXCXE-Dependent and TP53-Independent Mechanism (Q64274647)

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object named as

Teneale A Stewart

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Jennifer L McCann

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object named as

Jennifer L McCann

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author name string

Gabriel J Starrett

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Artur A Serebrenik

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Pieter A Roelofs

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Brandy Verhalen

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Matthew C Jarvis

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Emily K Law

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Annabel Krupp

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Mengxi Jiang

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John W M Martens

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Ellen Cahir-McFarland

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Paul N Span

The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein

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language of work or name

English

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publication date

5 February 2019

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published in

mBio

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volume

10

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issue

1

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cites work

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The region of the HPV E7 oncoprotein homologous to adenovirus E1a and Sv40 large T antigen contains separate domains for Rb binding and casein kinase II phosphorylation

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SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family

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Inactivation of the retinoblastoma susceptibility protein is not sufficient for the transforming function of the conserved region 2-like domain of simian virus 40 large T antigen.

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WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis

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mdm2 expression is induced by wild type p53 activity

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BK virus large T antigen: interactions with the retinoblastoma family of tumor suppressor proteins and effects on cellular growth control

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Regulation of expression of nuclear and mitochondrial forms of human uracil-DNA glycosylase

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p107 and p130: versatile proteins with interesting pockets

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Myc suppression of the p21 Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

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BKV and SV40 infection of human kidney tubular epithelial cells in vitro

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FoxM1 is required for execution of the mitotic programme and chromosome stability

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Role of the interaction between large T antigen and Rb family members in the oncogenicity of JC virus

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Rates of evolutionary change in viruses: patterns and determinants

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Evidence for editing of human papillomavirus DNA by APOBEC3 in benign and precancerous lesions

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Early events during BK virus entry and disassembly

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A truncated T antigen expressed from an alternatively spliced BK virus early mRNA.

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Mechanism of genomic instability in cells infected with the high-risk human papillomaviruses

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Functional reorganization of promyelocytic leukemia nuclear bodies during BK virus infection

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The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycle

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Roles of ATM and ATR-mediated DNA damage responses during lytic BK polyomavirus infection

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APOBEC3B is an enzymatic source of mutation in breast cancer.

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A cornucopia of human polyomaviruses

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Evidence for APOBEC3B mutagenesis in multiple human cancers

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APOBEC3 deaminases induce hypermutation in human papillomavirus 16 DNA upon beta interferon stimulation.

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In vitro and in vivo growth suppression of human papillomavirus 16-positive cervical cancer cells by CRISPR/Cas9.

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Discovery of biomarkers predictive of GSI response in triple-negative breast cancer and adenoid cystic carcinoma

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Elevated APOBEC3B correlates with poor outcomes for estrogen-receptor-positive breast cancers

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The NF-κB genomic landscape in lymphoblastoid B cells

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APOBEC3A functions as a restriction factor of human papillomavirus

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Human papillomavirus E6 triggers upregulation of the antiviral and cancer genomic DNA deaminase APOBEC3B

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The history and future of targeting cyclin-dependent kinases in cancer therapy

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APOBEC3B expression in breast cancer reflects cellular proliferation, while a deletion polymorphism is associated with immune activation

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Ferroptosis as a p53-mediated activity during tumour suppression

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Identification of APOBEC3B promoter elements responsible for activation by human papillomavirus type 16 E6.

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APOBECs and virus restriction

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Extremely High Mutation Rate of HIV-1 In Vivo

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DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway

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The PKC/NF-κB signaling pathway induces APOBEC3B expression in multiple human cancers

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Targeting CDK4 and CDK6: From Discovery to Therapy

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APOBEC-induced mutations in human cancers are strongly enriched on the lagging DNA strand during replication

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Mutational Strand Asymmetries in Cancer Genomes Reveal Mechanisms of DNA Damage and Repair

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APOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA Replication

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Strand-biased cytosine deamination at the replication fork causes cytosine to thymine mutations in Escherichia coli.

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APOBEC3G Expression Correlates with T-Cell Infiltration and Improved Clinical Outcomes in High-grade Serous Ovarian Carcinoma

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Treating cancer with selective CDK4/6 inhibitors

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The Ancient Evolutionary History of Polyomaviruses

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Functional Upregulation of the DNA Cytosine Deaminase APOBEC3B by Polyomaviruses.

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Integration of TP53, DREAM, MMB-FOXM1 and RB-E2F target gene analyses identifies cell cycle gene regulatory networks.

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Mechanisms of viral mutation

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Role of the host restriction factor APOBEC3 on papillomavirus evolution

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The DNA cytosine deaminase APOBEC3B promotes tamoxifen resistance in ER-positive breast cancer.

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Bats, Primates, and the Evolutionary Origins and Diversification of Mammalian Gammaherpesviruses

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Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B.

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Human Papillomavirus 16 E6 Upregulates APOBEC3B via the TEAD Transcription Factor

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Cell cycle proteins as promising targets in cancer therapy

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Inhibitors of cyclin-dependent kinases as cancer therapeutics

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Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity

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Elevated APOBEC3B expression drives a kataegic-like mutation signature and replication stress-related therapeutic vulnerabilities in p53-defective cells

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CDK4 phosphorylation status and a linked gene expression profile predict sensitivity to palbociclib

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HPV16 E7 Genetic Conservation Is Critical to Carcinogenesis

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12 December 2020

p53 controls expression of the DNA deaminase APOBEC3B to limit its potential mutagenic activity in cancer cells

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12 December 2020

NRF2 Is a Major Target of ARF in p53-Independent Tumor Suppression

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12 December 2020

APOBEC mutagenesis in drug resistance and immune escape in HIV and cancer evolution

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12 December 2020

Characterization of BK Polyomaviruses from Kidney Transplant Recipients Suggests a Role for APOBEC3 in Driving In-Host Virus Evolution.

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12 December 2020