HIV-1 nuclear import in macrophages is regulated by CPSF6-capsid interactions at the nuclear pore complex (Q64237728)

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20 April 2020

title

HIV-1 nuclear import in macrophages is regulated by CPSF6-capsid interactions at the nuclear pore complex (English)

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20 April 2020

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Pre-integration complex

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author

David Alejandro Bejarano

1

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20 April 2020

Ke Peng

2

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20 April 2020

Vibor Laketa

3

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20 April 2020

Bojana Lucic

6

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20 April 2020

Marina Lusic

8

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20 April 2020

Barbara Müller

9

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20 April 2020

Hans-Georg Kräusslich

10

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20 April 2020

4

Kathleen Börner

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20 April 2020

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Bärbel Glass

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20 April 2020

author name string

K Laurence Jost

5

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20 April 2020

language of work or name

English

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publication date

23 January 2019

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20 April 2020

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20 April 2020

volume

8

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Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone

20 April 2020

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Macrophage tropism of HIV-1 depends on efficient cellular dNTP utilization by reverse transcriptase

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Nuclear Pore Complex Structure and Dynamics Revealed by Cryoelectron Tomography

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HIV-1 DNA Flap formation promotes uncoating of the pre-integration complex at the nuclear pore

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HIV-1 pre-integration complexes selectively target decondensed chromatin in the nuclear periphery

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HIV Capsid is a Tractable Target for Small Molecule Therapeutic Intervention

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Far-field optical nanoscopy with reduced number of state transition cycles

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Transportin 3 promotes a nuclear maturation step required for efficient HIV-1 integration.

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HIV-1 replication in the central nervous system occurs in two distinct cell types.

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12 December 2020

HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiency

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Human immunodeficiency virus type 1 capsid mutation N74D alters cyclophilin A dependence and impairs macrophage infection

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12 December 2020

CPSF6 Defines a Conserved Capsid Interface that Modulates HIV-1 Replication

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HIV-1 reverse transcription

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12 December 2020

Cleavage factor Im is a key regulator of 3' UTR length.

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12 December 2020

TNPO3 protects HIV-1 replication from CPSF6-mediated capsid stabilization in the host cell cytoplasm.

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12 December 2020

The ability of TNPO3-depleted cells to inhibit HIV-1 infection requires CPSF6.

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12 December 2020

A carboxy-terminally truncated human CPSF6 lacking residues encoded by exon 6 inhibits HIV-1 cDNA synthesis and promotes capsid disassembly

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12 December 2020

Evidence for biphasic uncoating during HIV-1 infection from a novel imaging assay

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12 December 2020

Viral and cellular requirements for the nuclear entry of retroviral preintegration nucleoprotein complexes

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12 December 2020

Nucleoporin NUP153 phenylalanine-glycine motifs engage a common binding pocket within the HIV-1 capsid protein to mediate lentiviral infectivity

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12 December 2020

HIV-1 evades innate immune recognition through specific cofactor recruitment

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12 December 2020

A model for cofactor use during HIV-1 reverse transcription and nuclear entry

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12 December 2020

HIV-1 uncoating: connection to nuclear entry and regulation by host proteins

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12 December 2020

Molecular mechanisms of retroviral integration site selection

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12 December 2020

Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly.

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12 December 2020

Quantitative microscopy of functional HIV post-entry complexes reveals association of replication with the viral capsid

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12 December 2020

Structural basis of HIV-1 capsid recognition by PF74 and CPSF6.

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12 December 2020

Host factors for retroviral integration site selection

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12 December 2020

Complementary Assays Reveal a Low Level of CA Associated with Viral Complexes in the Nuclei of HIV-1-Infected Cells

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12 December 2020

HIV-1 capsid: the multifaceted key player in HIV-1 infection

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12 December 2020

Cellular and viral determinants of retroviral nuclear entry

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12 December 2020

Direct Visualization of HIV-1 Replication Intermediates Shows that Capsid and CPSF6 Modulate HIV-1 Intra-nuclear Invasion and Integration

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12 December 2020

A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin

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12 December 2020

The Cleavage and Polyadenylation Specificity Factor 6 (CPSF6) Subunit of the Capsid-recruited Pre-messenger RNA Cleavage Factor I (CFIm) Complex Mediates HIV-1 Integration into Genes

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12 December 2020

Roles of Capsid-Interacting Host Factors in Multimodal Inhibition of HIV-1 by PF74.

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12 December 2020

HIV-1 capsid is involved in post-nuclear entry steps

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12 December 2020

Capsid-CPSF6 Interaction Is Dispensable for HIV-1 Replication in Primary Cells but Is Selected during Virus Passage In Vivo

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12 December 2020

Cleavage factor Im (CFIm) as a regulator of alternative polyadenylation

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12 December 2020

Imaging HIV-1 Genomic DNA from Entry through Productive Infection

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12 December 2020

Capsid-Dependent Host Factors in HIV-1 Infection

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12 December 2020

Relevance of assembly-activating protein for Adeno-associated virus vector production and capsid protein stability in mammalian and insect cells

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12 December 2020

Early cytoplasmic uncoating is associated with infectivity of HIV-1.

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12 December 2020

Dynamics and regulation of nuclear import and nuclear movements of HIV-1 complexes

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12 December 2020

Cellular and molecular mechanisms of HIV-1 integration targeting.

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12 December 2020

Single HIV-1 Imaging Reveals Progression of Infection through CA-Dependent Steps of Docking at the Nuclear Pore, Uncoating, and Nuclear Transport

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12 December 2020

Kinetics of HIV-1 capsid uncoating revealed by single-molecule analysis.

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12 December 2020

Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration

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Detailed Characterization of Early HIV-1 Replication Dynamics in Primary Human Macrophages

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12 December 2020

Identifiers

DOI

10.7554/ELIFE.41800

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20 April 2020

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20 April 2020

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