Somatic alterations of TP53, ERBB2, PIK3CA and CCND1 are associated with chemosensitivity for breast cancers (Q64074228)

2

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Longlong Bao

3

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Xiaoyan Zhou

4

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Zhe Wang

5

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Peizhen Hu

6

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Nengtai Ouyang

7

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Xiaojuan Li

8

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Yi Shi

9

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Gang Chen

10

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Peiyi Xia

11

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Meiying Chui

12

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Wencai Li

13

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Ying Jia

14

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Yueping Liu

15

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Junjun Liu

16

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Junyi Ye

17

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Zhe Zhang

18

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Hong Bu

Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice

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language of work or name

English

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publication date

April 2019

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published in

Cancer Science

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volume

110

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issue

4

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page(s)

1389-1400

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cites work

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Inhibition of cyclin D1 expression in human pancreatic cancer cells is associated with increased chemosensitivity and decreased expression of multiple chemoresistance genes.

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Amplification and deletion of topoisomerase IIalpha associate with ErbB-2 amplification and affect sensitivity to topoisomerase II inhibitor doxorubicin in breast cancer

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Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance

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Apoptosis: a link between cancer genetics and chemotherapy

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Inhibition of phosphatidylinositol 3'-kinase increases efficacy of paclitaxel in in vitro and in vivo ovarian cancer models.

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Repeated observation of breast tumor subtypes in independent gene expression data sets

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Comparative value of tumour grade, hormonal receptors, Ki-67, HER-2 and topoisomerase II alpha status as predictive markers in breast cancer patients treated with neoadjuvant anthracycline-based chemotherapy

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Overexpression of cyclin D1 promotes tumor cell growth and confers resistance to cisplatin-mediated apoptosis in an elastase-myc transgene-expressing pancreatic tumor cell line

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Elevated expression of mitogen-activated protein kinase phosphatase 3 in breast tumors: a mechanism of tamoxifen resistance

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Pharmacogenomic predictor of sensitivity to preoperative chemotherapy with paclitaxel and fluorouracil, doxorubicin, and cyclophosphamide in breast cancer.

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Residual ductal carcinoma in situ in patients with complete eradication of invasive breast cancer after neoadjuvant chemotherapy does not adversely affect patient outcome

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FOXA1 Expression in Breast Cancer Correlation with Luminal Subtype A and Survival

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Preoperative chemotherapy: updates of National Surgical Adjuvant Breast and Bowel Project Protocols B-18 and B-27.

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Biological markers as predictive factors of response to neoadjuvant taxanes and anthracycline chemotherapy in breast carcinoma.

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Targeting the RAF-MEK-ERK pathway in cancer therapy

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Induction of Akt activity by chemotherapy confers acquired resistance

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Genomic grade index is associated with response to chemotherapy in patients with breast cancer

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High CCND1 amplification identifies a group of poor prognosis women with estrogen receptor positive breast cancer

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Association between HER2, TOP2A, and response to anthracycline-based preoperative chemotherapy in high-risk primary breast cancer

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FGFR4 Arg388 genotype is associated with pathological complete response to neoadjuvant chemotherapy for primary breast cancer

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ER, PgR, HER-2, Ki-67, topoisomerase IIα, and nm23-H1 proteins expression as predictors of pathological complete response to neoadjuvant chemotherapy for locally advanced breast cancer

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GSK1120212 (JTP-74057) is an inhibitor of MEK activity and activation with favorable pharmacokinetic properties for sustained in vivo pathway inhibition

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Association of the germline TP53 R72P and MDM2 SNP309 variants with breast cancer survival in specific breast tumor subgroups.

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Association between c-myc amplification and pathological complete response to neoadjuvant chemotherapy in breast cancer

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Small interfering RNAs targeting cyclin D1 and cyclin D2 enhance the cytotoxicity of chemotherapeutic agents in mantle cell lymphoma cell lines

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Outcome of triple-negative breast cancer in patients with or without deleterious BRCA mutations

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RAS mutations are associated with the development of cutaneous squamous cell tumors in patients treated with RAF inhibitors

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12 December 2020

RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors

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Effects of cyclin D1 gene amplification and protein expression on time to recurrence in postmenopausal breast cancer patients treated with anastrozole or tamoxifen: a TransATAC study

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The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

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Improved survival with MEK inhibition in BRAF-mutated melanoma

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Comprehensive molecular portraits of human breast tumours

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GATA3 acts upstream of FOXA1 in mediating ESR1 binding by shaping enhancer accessibility

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Phosphatidylinositol 3-kinases inhibitor LY294002 potentiates the cytotoxic effects of doxorubicin, vincristine, and etoposide in a panel of cancer cell lines.

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Mutational landscape and significance across 12 major cancer types

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Mutations in EGFR, BRAF and RAS are rare in triple-negative and basal-like breast cancers from Caucasian women

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Pathological complete response and long-term clinical benefit in breast cancer: the CTNeoBC pooled analysis

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Cyclin D1 gene amplification is highly homogeneous in breast cancer

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Mutational analysis of PI3K/AKT signaling pathway in tamoxifen exemestane adjuvant multinational pathology study.

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Frequency of mutations in individuals with breast cancer referred for BRCA1 and BRCA2 testing using next-generation sequencing with a 25-gene panel

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PIK3CA mutations are associated with decreased benefit to neoadjuvant human epidermal growth factor receptor 2-targeted therapies in breast cancer

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12 December 2020

Association of PIK3CA Mutation Status before and after Neoadjuvant Chemotherapy with Response to Chemotherapy in Women with Breast Cancer

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12 December 2020

Molecular characterization of patients with pathologic complete response or early failure after neoadjuvant chemotherapy for locally advanced breast cancer using next generation sequencing and nCounter assay

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12 December 2020

Inhibiting the PI3K signaling pathway: buparlisib as a new targeted option in breast carcinoma

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12 December 2020

p53 as an Effector or Inhibitor of Therapy Response

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12 December 2020

Hereditary truncating mutations of DNA repair and other genes inBRCA1/BRCA2/PALB2-negatively tested breast cancer patients

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12 December 2020

Multiple gene sequencing for risk assessment in patients with early-onset or familial breast cancer

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BRCA1-2 diagnostic workflow from next-generation sequencing technologies to variant identification and final report

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12 December 2020

A microscopic landscape of the invasive breast cancer genome

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Clinical implications of routine genomic mutation sequencing in PIK3CA/AKT1 and KRAS/NRAS/BRAF in metastatic breast cancer.

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12 December 2020

PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation

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12 December 2020