MICU1 and MICU2 Play an Essential Role in Mitochondrial Ca Uptake, Growth, and Infectivity of the Human Pathogen Trypanosoma cruzi (Q64064090)

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25 April 2020

title

MICU1 and MICU2 Play an Essential Role in Mitochondrial Ca2+ Uptake, Growth, and Infectivity of the Human Pathogen Trypanosoma cruzi (English)

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25 April 2020

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25 April 2020

Roberto Docampo

5

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25 April 2020

author name string

Mayara S Bertolini

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25 April 2020

Noelia Lander

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25 April 2020

Anibal E Vercesi

4

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25 April 2020

language of work or name

English

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publication date

7 May 2019

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25 April 2020

volume

10

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issue

3

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Calcium homeostasis in Trypanosoma cruzi amastigotes: presence of inositol phosphates and lack of an inositol 1,4,5-trisphosphate-sensitive calcium pool

25 April 2020

cites work

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Ca2+ transport by coupled Trypanosoma cruzi mitochondria in situ

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Characteristics of Ca2+ transport by Trypanosoma cruzi mitochondria in situ

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The kinetic properties of citrate synthase from rat liver mitochondria

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Transport of calcium by mitochondria

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Cytosolic-free calcium elevation in Trypanosoma cruzi is required for cell invasion

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Computational method to predict mitochondrially imported proteins and their targeting sequences

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Localization of lectin-binding sites on the surface of Trypanosoma cruzi grown in chemically defined conditions

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Increased mitochondrial mass in mitochondrial myopathy mice

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Isotopes incorporated in the Nucleic Acids of Trypanosoma mega

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Calcium uptake by rat kidney mitochondria

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Free fatty acids in carrot-tissue preparations and their effect on isolated carrot mitochondria

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ScanProsite: detection of PROSITE signature matches and ProRule-associated functional and structural residues in proteins

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Mitochondrial membrane permeabilization in cell death

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Autophagy is involved in nutritional stress response and differentiation in Trypanosoma cruzi.

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Localization and developmental regulation of a dispersed gene family 1 protein in Trypanosoma cruzi

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TriTrypDB: a functional genomic resource for the Trypanosomatidae

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The fateful encounter of mitochondria with calcium: how did it happen?

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12 December 2020

MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake

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12 December 2020

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

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12 December 2020

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

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The higher susceptibility of congenital analbuminemic rats to Ca2+-induced mitochondrial permeability transition is associated with the increased expression of cyclophilin D and nitrosothiol depletion.

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High-resolution respirometry: OXPHOS protocols for human cells and permeabilized fibers from small biopsies of human muscle

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Safranine as a fluorescent probe for the evaluation of mitochondrial membrane potential in isolated organelles and permeabilized cells.

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Trypanosomes and the solution to a 50-year mitochondrial calcium mystery

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12 December 2020

A role of autophagy in Trypanosoma brucei cell death.

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12 December 2020

Evolutionary diversity of the mitochondrial calcium uniporter

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12 December 2020

MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival

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12 December 2020

MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism

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12 December 2020

MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling

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12 December 2020

MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporter

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12 December 2020

The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit

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12 December 2020

Paratrypanosoma Is a Novel Early-Branching Trypanosomatid

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12 December 2020

Trypanosoma brucei vacuolar transporter chaperone 4 (TbVtc4) is an acidocalcisome polyphosphate kinase required for in vivo infection

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12 December 2020

EMRE is an essential component of the mitochondrial calcium uniporter complex

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12 December 2020

Essential regulation of cell bioenergetics in Trypanosoma brucei by the mitochondrial calcium uniporter

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12 December 2020

MICU1 and MICU2 play nonredundant roles in the regulation of the mitochondrial calcium uniporter

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12 December 2020

MICU1 and MICU2 finely tune the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activity

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12 December 2020

Evolution of parasitism in kinetoplastid flagellates.

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12 December 2020

Mitochondrial calcium transport in trypanosomes

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12 December 2020

Tissue and sex specificities in Ca2+ handling by isolated mitochondria in conditions avoiding the permeability transition.

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12 December 2020

CRISPR/Cas9-Induced Disruption of Paraflagellar Rod Protein 1 and 2 Genes in Trypanosoma cruzi Reveals Their Role in Flagellar Attachment

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12 December 2020

The Ca(2+)-Dependent Release of the Mia40-Induced MICU1-MICU2 Dimer from MCU Regulates Mitochondrial Ca(2+) Uptake

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12 December 2020

EMRE Is a Matrix Ca(2+) Sensor that Governs Gatekeeping of the Mitochondrial Ca(2+) Uniporter.

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12 December 2020

Functional roles of MICU1 and MICU2 in mitochondrial Ca(2+) uptake

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12 December 2020

MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets

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12 December 2020

Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complex

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12 December 2020

Expression and preliminary characterization of human MICU2.

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12 December 2020

MICU1 Serves as a Molecular Gatekeeper to Prevent In Vivo Mitochondrial Calcium Overload

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12 December 2020

Tissue-Specific Mitochondrial Decoding of Cytoplasmic Ca2+ Signals Is Controlled by the Stoichiometry of MICU1/2 and MCU.

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12 December 2020

Different Roles of Mitochondrial Calcium Uniporter Complex Subunits in Growth and Infectivity of Trypanosoma cruzi

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12 December 2020

Confidence Limits on Phylogenies: an Approach using the Bootstrap

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12 December 2020

High-affinity cooperative Ca2+ binding by MICU1-MICU2 serves as an on-off switch for the uniporter.

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12 December 2020

The MCU complex in cell death.

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12 December 2020

RNA targeting with CRISPR-Cas13.

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12 December 2020

Cardiovascular homeostasis dependence on MICU2, a regulatory subunit of the mitochondrial calcium uniporter

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12 December 2020

MICU2 Restricts Spatial Crosstalk between InsP3R and MCU Channels by Regulating Threshold and Gain of MICU1-Mediated Inhibition and Activation of MCU.

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12 December 2020

An Intracellular Ammonium Transporter Is Necessary for Replication, Differentiation, and Resistance to Starvation and Osmotic Stress in Trypanosoma cruzi.

1 reference

12 December 2020

Cryo-EM structure of a mitochondrial calcium uniporter

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12 December 2020

Cryo-EM structure of a fungal mitochondrial calcium uniporter

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12 December 2020

X-ray and cryo-EM structures of the mitochondrial calcium uniporter

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12 December 2020

Cryo-EM structures of fungal and metazoan mitochondrial calcium uniporters

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12 December 2020

The machineries, regulation and cellular functions of mitochondrial calcium

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12 December 2020

The Mitochondrial Ca Uniporter Complex (MCUC) of Trypanosoma brucei Is a Hetero-oligomer That Contains Novel Subunits Essential for Ca Uptake

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12 December 2020

Calcium-sensitive pyruvate dehydrogenase phosphatase is required for energy metabolism, growth, differentiation, and infectivity of

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12 December 2020

MICU1 Interacts with the D-Ring of the MCU Pore to Control Its Ca2+ Flux and Sensitivity to Ru360

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12 December 2020

The conserved aspartate ring of MCU mediates MICU1 binding and regulation in the mitochondrial calcium uniporter complex

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12 December 2020

Identifiers

DOI

10.1128/MBIO.00348-19

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31064825%20AND%20SRC:MED&resulttype=core&format=json

25 April 2020

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25 April 2020

PubMed publication ID

31064825

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