HLA-E: exploiting pathogen-host interactions for vaccine development (Q64062672)

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2 May 2020

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HLA-E: exploiting pathogen-host interactions for vaccine development (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30968409%20AND%20SRC:MED&resulttype=core&format=json

host microbial interaction

2 May 2020

main subject

immunology

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27 July 2020

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2 May 2020

Georgina Bowyer

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2 May 2020

Simon Brackenridge

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2 May 2020

Teresa Lambe

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T Lambe

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H R Sharpe

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G Bowyer

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S Brackenridge

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language of work or name

English

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publication date

9 April 2019

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Clinical and Experimental Immunology

2 May 2020

1 May 2019

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22 August 2022

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196

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issue

2

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2 May 2020

page(s)

167-177

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Creative Commons Attribution

2 May 2020

copyright license

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Polymorphism at the HLA-E locus predates most HLA-A and -B polymorphism

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12 December 2020

Severe herpesvirus infections in an adolescent without natural killer cells

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12 December 2020

The MHC E locus in macaques is polymorphic and is conserved between macaques and humans

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12 December 2020

The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol

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12 December 2020

Population genetic studies of HLA-E: evidence for selection.

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12 December 2020

The human major histocompatibility complex class Ib molecule HLA-E binds signal sequence-derived peptides with primary anchor residues at positions 2 and 9

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12 December 2020

A viral ER-resident glycoprotein inactivates the MHC-encoded peptide transporter.

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12 December 2020

TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide

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12 December 2020

HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C

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12 December 2020

Structural features impose tight peptide binding specificity in the nonclassical MHC molecule HLA-E

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12 December 2020

HLA-E-bound peptides influence recognition by inhibitory and triggering CD94/NKG2 receptors: preferential response to an HLA-G-derived nonamer

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12 December 2020

The inhibitory receptor LIR-1 uses a common binding interaction to recognize class I MHC molecules and the viral homolog UL18.

1 reference

12 December 2020

Paired inhibitory and triggering NK cell receptors for HLA class I molecules.

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12 December 2020

Surface expression of HLA-E, an inhibitor of natural killer cells, enhanced by human cytomegalovirus gpUL40.

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12 December 2020

Cutting edge: the human cytomegalovirus UL40 gene product contains a ligand for HLA-E and prevents NK cell-mediated lysis

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12 December 2020

Functional heterogeneity and high frequencies of cytomegalovirus-specific CD8(+) T lymphocytes in healthy seropositive donors.

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12 December 2020

Polymorphism and evolution of HLA class I and II genes and molecules

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12 December 2020

Human T cell receptor-mediated recognition of HLA-E.

1 reference

12 December 2020

UL40-mediated NK evasion during productive infection with human cytomegalovirus.

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12 December 2020

HLA-E allelic variants. Correlating differential expression, peptide affinities, crystal structures, and thermal stabilities

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12 December 2020

Definitive high resolution typing of HLA-E allelic polymorphisms: Identifying potential errors in existing allele data

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12 December 2020

A signal peptide derived from hsp60 binds HLA-E and interferes with CD94/NKG2A recognition

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12 December 2020

HLA-E-dependent presentation of Mtb-derived antigen to human CD8+ T cells

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12 December 2020

Complete sequence and genomic analysis of rhesus cytomegalovirus

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12 December 2020

Human cytomegalovirus inhibits tapasin-dependent peptide loading and optimization of the MHC class I peptide cargo for immune evasion

1 reference

12 December 2020

Evolutionary relationships of major histocompatibility complex class I genes in simian primates

1 reference

12 December 2020

Qa-1, a nonclassical class I histocompatibility molecule with roles in innate and adaptive immunity

1 reference

12 December 2020

Identification of a human HLA-E-restricted CD8+ T cell subset in volunteers immunized with Salmonella enterica serovar Typhi strain Ty21a typhoid vaccine

1 reference

12 December 2020

HIV-1 infection leads to increased HLA-E expression resulting in impaired function of natural killer cells

1 reference

12 December 2020

Simian Immunodeficiency Virus Infection of Chimpanzees

1 reference

12 December 2020

Rhesus cytomegalovirus contains functional homologues of US2, US3, US6, and US11.

1 reference

12 December 2020

MHC class Ib molecules bridge innate and acquired immunity

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12 December 2020

Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects

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12 December 2020

Identification of effector-memory CMV-specific T lymphocytes that kill CMV-infected target cells in an HLA-E-restricted fashion.

1 reference

12 December 2020

Structural basis for a major histocompatibility complex class Ib-restricted T cell response

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12 December 2020

The role of human leukocyte antigen E and G in HIV infection

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12 December 2020

Non-classical MHC-E (Mamu-E) expression in the rhesus monkey placenta

1 reference

12 December 2020

Modulation of natural killer cells by human cytomegalovirus

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12 December 2020

The heterodimeric assembly of the CD94-NKG2 receptor family and implications for human leukocyte antigen-E recognition

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12 December 2020

Rhesus CMV: an emerging animal model for human CMV.

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12 December 2020

CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence

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12 December 2020

Subtle changes in peptide conformation profoundly affect recognition of the non-classical MHC class I molecule HLA-E by the CD94-NKG2 natural killer cell receptors

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12 December 2020

Structural basis for NKG2A/CD94 recognition of HLA-E.

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12 December 2020

Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge

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12 December 2020

Chronic HIV-1 viremia reverses NKG2A/NKG2C ratio on natural killer cells in patients with human cytomegalovirus co-infection.

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12 December 2020

Mycobacterium tuberculosis peptides presented by HLA-E molecules are targets for human CD8 T-cells with cytotoxic as well as regulatory activity

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12 December 2020

Evasion of CD8+ T cells is critical for superinfection by cytomegalovirus

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12 December 2020

The other Janus face of Qa-1 and HLA-E: diverse peptide repertoires in times of stress

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12 December 2020

Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine

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12 December 2020

Trained immunity: a memory for innate host defense

1 reference

12 December 2020

Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques

1 reference

12 December 2020

Non-classical HLA-E gene variability in Brazilians: a nearly invariable locus surrounded by the most variable genes in the human genome

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12 December 2020

A single autoimmune T cell receptor recognizes more than a million different peptides

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12 December 2020

Alternative peptide repertoire of HLA-E reveals a binding motif that is strikingly similar to HLA-A2

1 reference

12 December 2020

Polymorphism in human cytomegalovirus UL40 impacts on recognition of human leukocyte antigen-E (HLA-E) by natural killer cells.

1 reference

12 December 2020

NK cell CD16 surface expression and function is regulated by a disintegrin and metalloprotease-17 (ADAM17).

1 reference

12 December 2020

Controlling natural killer cell responses: integration of signals for activation and inhibition

1 reference

12 December 2020

Adaptive reconfiguration of the human NK-cell compartment in response to cytomegalovirus: a different perspective of the host-pathogen interaction

1 reference

12 December 2020

Cytomegalovirus vectors violate CD8+ T cell epitope recognition paradigms

1 reference

12 December 2020

Training innate immunity: the changing concept of immunological memory in innate host defence

1 reference

12 December 2020

Immune clearance of highly pathogenic SIV infection

1 reference

12 December 2020

Synergistic inhibition of natural killer cells by the nonsignaling molecule CD94.

1 reference

12 December 2020

Worldwide HLA-E nucleotide and haplotype variability reveals a conserved gene for coding and 3' untranslated regions.

1 reference

12 December 2020

Human NK cell response to pathogens

1 reference

12 December 2020

The effect of adenovirus-specific antibodies on adenoviral vector-induced, transgene product-specific T cell responses

1 reference

12 December 2020

Natural killer cells: a coherent model for their functional role in Mycobacterium tuberculosis infection.

1 reference

12 December 2020

Autophagy controls BCG-induced trained immunity and the response to intravesical BCG therapy for bladder cancer

1 reference

12 December 2020

NK cells and their ability to modulate T cells during virus infections

1 reference

12 December 2020

Cytomegalovirus generates long-lived antigen-specific NK cells with diminished bystander activation to heterologous infection

1 reference

12 December 2020

BCG-induced trained immunity in NK cells: Role for non-specific protection to infection

1 reference

12 December 2020

Human CD8 T lymphocytes recognize Mycobacterium tuberculosis antigens presented by HLA-E during active tuberculosis and express type 2 cytokines

1 reference

12 December 2020

Peptide-induced HLA-E expression in human PBMCs is dependent on peptide sequence and the HLA-E genotype

1 reference

12 December 2020

Human CD8+ T-cells recognizing peptides from Mycobacterium tuberculosis (Mtb) presented by HLA-E have an unorthodox Th2-like, multifunctional, Mtb inhibitory phenotype and represent a novel human T-cell subset.

1 reference

12 December 2020

Trained innate immunity as underlying mechanism for the long-term, nonspecific effects of vaccines

1 reference

12 December 2020

HLA-E regulates NKG2C+ natural killer cell function through presentation of a restricted peptide repertoire

1 reference

12 December 2020

The diversity of the HLA-E-restricted peptide repertoire explains the immunological impact of the Arg107Gly mismatch

1 reference

12 December 2020

Broadly targeted CD8⁺ T cell responses restricted by major histocompatibility complex E.

1 reference

12 December 2020

A Conserved HIV-1-Derived Peptide Presented by HLA-E Renders Infected T-cells Highly Susceptible to Attack by NKG2A/CD94-Bearing Natural Killer Cells.

1 reference

12 December 2020

The cells that mediate innate immune memory and their functional significance in inflammatory and infectious diseases.

1 reference

12 December 2020

A Phase 1 Study of 4 Live, Recombinant Human Cytomegalovirus Towne/Toledo Chimera Vaccines in Cytomegalovirus-Seronegative Men

1 reference

12 December 2020

Characteristics of HLA-E Restricted T-Cell Responses and Their Role in Infectious Diseases

1 reference

12 December 2020

Genomic analysis of chimeric human cytomegalovirus vaccine candidates derived from strains Towne and Toledo

1 reference

12 December 2020

MHC Ib molecule Qa-1 presents Mycobacterium tuberculosis peptide antigens to CD8+ T cells and contributes to protection against infection.

1 reference

12 December 2020

Unusual antigen presentation offers new insight into HIV vaccine design

1 reference

12 December 2020

The COMPLEXity in herpesvirus entry

1 reference

12 December 2020

Fibroblast-adapted human CMV vaccines elicit predominantly conventional CD8 T cell responses in humans.

1 reference

12 December 2020

HLA-E Presents Glycopeptides from the Mycobacterium tuberculosis Protein MPT32 to Human CD8+ T cells

1 reference

12 December 2020

CD8+ T cell programming by cytomegalovirus vectors: applications in prophylactic and therapeutic vaccination

1 reference

12 December 2020

Detailed characterization of human Mycobacterium tuberculosis specific HLA-E restricted CD8+ T cells.

1 reference

12 December 2020

The Role of MHC-E in T Cell Immunity Is Conserved among Humans, Rhesus Macaques, and Cynomolgus Macaques

1 reference

12 December 2020

T cell recognition of Mycobacterium tuberculosis peptides presented by HLA-E derived from infected human cells

1 reference

12 December 2020

Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine.

1 reference

12 December 2020

Infectious Agents as Stimuli of Trained Innate Immunity

1 reference

12 December 2020

Functional and Phenotypic Changes of Natural Killer Cells in Whole Blood during Mycobacterium tuberculosis Infection and Disease.

1 reference

12 December 2020

The Effect of Human Immunodeficiency Virus and Cytomegalovirus Infection on Infant Responses to Vaccines: A Review.

1 reference

12 December 2020

The (gradual) rise of memory inflation.

1 reference

12 December 2020

Induction and Maintenance of CX3CR1-Intermediate Peripheral Memory CD8+ T Cells by Persistent Viruses and Vaccines.

1 reference

12 December 2020

HCMV triggers frequent and persistent UL40-specific unconventional HLA-E-restricted CD8 T-cell responses with potential autologous and allogeneic peptide recognition.

1 reference

12 December 2020

Liver HLA-E Expression Is Associated with Severity of Liver Disease in Chronic Hepatitis C.

1 reference

12 December 2020

Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding

1 reference

12 December 2020

Immune genes are primed for robust transcription by proximal long noncoding RNAs located in nuclear compartments

1 reference

12 December 2020

Identifiers

DOI

10.1111/CEI.13292

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30968409%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30968409%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

PubMed publication ID

30968409

1 reference