Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein (Q63879931)

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scientific article published on 01 January 2019

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English	Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein	scientific article published on 01 January 2019

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scholarly article

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1 May 2020

Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein (English)

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infectious disease

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based on heuristic

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based on heuristic

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monoclonal antibody

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Javier Gutiérrez-Álvarez

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Victor Stalin Raj

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Raul Fernandez-Delgado

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Bart L. Haagmans

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Berend Jan Bosch

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Berend-Jan Bosch

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Frank J. M. van Kuppeveld

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Frank J M van Kuppeveld

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author name string

Ivy Widjaja

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Chunyan Wang

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Rien van Haperen

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Brenda van Dieren

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Frank Grosveld

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Dubravka Drabek

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Luis Enjuanes

13

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1 January 2019

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Emerging Microbes & Infections

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8

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1

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516-530

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copyright license

Creative Commons Attribution 4.0 International

1 January 2019

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April 2022 Public Data File from Crossref

copyright status

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April 2022 Public Data File from Crossref

Novel human monoclonal antibody combination effectively neutralizing natural rabies virus variants and individual in vitro escape mutants

1 reference

https://pubmed.ncbi.nlm.nih.gov/30938227

12 December 2020

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Developments towards effective treatments for Nipah and Hendra virus infection

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https://pubmed.ncbi.nlm.nih.gov/30938227

12 December 2020

based on heuristic

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Acquisition of complement resistance through incorporation of CD55/decay-accelerating factor into viral particles bearing baculovirus GP64.

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A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins

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Successful treatment of ebola virus-infected cynomolgus macaques with monoclonal antibodies

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https://pubmed.ncbi.nlm.nih.gov/30938227

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Crosstalk between human IgG isotypes and murine effector cells

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https://pubmed.ncbi.nlm.nih.gov/30938227

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Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC

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Development of a highly protective combination monoclonal antibody therapy against Chikungunya virus

1 reference

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The receptor binding domain of the new Middle East respiratory syndrome coronavirus maps to a 231-residue region in the spike protein that efficiently elicits neutralizing antibodies

1 reference

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12 December 2020

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Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation

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https://pubmed.ncbi.nlm.nih.gov/30938227

12 December 2020

based on heuristic

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A conformation-dependent neutralizing monoclonal antibody specifically targeting receptor-binding domain in Middle East respiratory syndrome coronavirus spike protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30938227

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of human neutralizing antibodies against MERS-CoV and their role in virus adaptive evolution

1 reference

https://pubmed.ncbi.nlm.nih.gov/30938227

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potent neutralization of MERS-CoV by human neutralizing monoclonal antibodies to the viral spike glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/30938227

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exceptionally potent neutralization of Middle East respiratory syndrome coronavirus by human monoclonal antibodies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30938227

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia, 2013.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30938227

12 December 2020

based on heuristic

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Evidence for camel-to-human transmission of MERS coronavirus

1 reference

https://pubmed.ncbi.nlm.nih.gov/30938227

12 December 2020

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Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp

1 reference

https://pubmed.ncbi.nlm.nih.gov/30938227

12 December 2020

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Molecular characterization of the monoclonal antibodies composing ZMAb: a protective cocktail against Ebola virus

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https://pubmed.ncbi.nlm.nih.gov/30938227

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Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/30938227

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based on heuristic

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Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus

1 reference

https://pubmed.ncbi.nlm.nih.gov/30938227

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of candidate vaccine approaches for MERS-CoV.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30938227

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural basis for the neutralization of MERS-CoV by a human monoclonal antibody MERS-27

1 reference

https://pubmed.ncbi.nlm.nih.gov/30938227

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30938227

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Middle East Respiratory Syndrome Coronavirus Causes Multiple Organ Damage and Lethal Disease in Mice Transgenic for Human Dipeptidyl Peptidase 4.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30938227

12 December 2020

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3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012

1 reference

https://pubmed.ncbi.nlm.nih.gov/30938227

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30938227

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of an antibody for pan-ebolavirus therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/30938227

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Middle East respiratory syndrome coronavirus (MERS-CoV): animal to human interaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/30938227

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pre-fusion structure of a human coronavirus spike protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30938227

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prophylaxis With a Middle East Respiratory Syndrome Coronavirus (MERS-CoV)-Specific Human Monoclonal Antibody Protects Rabbits From MERS-CoV Infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/30938227

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single-dose treatment with a humanized neutralizing antibody affords full protection of a human transgenic mouse model from lethal Middle East respiratory syndrome (MERS)-coronavirus infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/30938227

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Feverish Quest for Ebola Immunotherapy: Straight or Cocktail?

1 reference

https://pubmed.ncbi.nlm.nih.gov/30938227

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Passive Transfer of A Germline-like Neutralizing Human Monoclonal Antibody Protects Transgenic Mice Against Lethal Middle East Respiratory Syndrome Coronavirus Infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/30938227

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycan shield and epitope masking of a coronavirus spike protein observed by cryo-electron microscopy

1 reference

https://pubmed.ncbi.nlm.nih.gov/30938227

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular Basis of Coronavirus Virulence and Vaccine Development

1 reference

https://pubmed.ncbi.nlm.nih.gov/30938227

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MERS-CoV spike protein: a key target for antivirals

1 reference

https://pubmed.ncbi.nlm.nih.gov/30938227

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains

1 reference

https://pubmed.ncbi.nlm.nih.gov/30938227

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of sialic acid-binding function for the Middle East respiratory syndrome coronavirus spike glycoprotein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30938227

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beyond binding: antibody effector functions in infectious diseases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30938227

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cryo-EM structure of porcine delta coronavirus spike protein in the pre-fusion state

1 reference

https://pubmed.ncbi.nlm.nih.gov/30938227

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tectonic conformational changes of a coronavirus spike glycoprotein promote membrane fusion.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30938227

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycan shield and fusion activation of a deltacoronavirus spike glycoprotein fine-tuned for enteric infections.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30938227

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Importance of neutralizing monoclonal antibodies targeting multiple antigenic sites on MERS-CoV Spike to avoid neutralization escape.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30938227

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cryo-EM structure of infectious bronchitis coronavirus spike protein reveals structural and functional evolution of coronavirus spike proteins.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30938227

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/30938227

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systematic Analysis of Monoclonal Antibodies against Ebola Virus GP Defines Features that Contribute to Protection

1 reference

https://pubmed.ncbi.nlm.nih.gov/30938227

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chimeric camel/human heavy-chain antibodies protect against MERS-CoV infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/30938227

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1080/22221751.2019.1597644

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30938227%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30938227%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30938227%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

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