Mutant insulin receptors in syndromes of insulin resistance (Q61908582)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8734453%20AND%20SRC:MED&resulttype=core&format=json

17 October 2019

review article

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title

Mutant insulin receptors in syndromes of insulin resistance (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8734453%20AND%20SRC:MED&resulttype=core&format=json

17 October 2019

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1

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17 October 2019

author name string

O'Rahilly S

series ordinal

2

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17 October 2019

language of work or name

English

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publication date

1 January 1996

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Bailliere's clinical endocrinology and metabolism

17 October 2019

published in

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17 October 2019

volume

10

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17 October 2019

page(s)

97-122

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17 October 2019

issue

1

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A 3-basepair in-frame deletion (delta Leu999) in exon 17 of the insulin receptor gene in a family with insulin resistance

17 October 2019

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Two mutant alleles of the insulin receptor gene in a family with a genetic form of insulin resistance: a 10 base pair deletion in exon 1 and a mutation substituting serine for asparagine-462.

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Phorbol esters induce insulin receptor phosphorylation in transfected fibroblasts without affecting tyrosine kinase activity

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A membrane-anchored cytoplasmic domain of the human insulin receptor mediates a constitutively elevated insulin-independent uptake of 2-deoxyglucose.

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Antibodies That Impair Insulin Receptor Binding in an Unusual Diabetic Syndrome with Severe Insulin Resistance

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Decreased kinase activity of insulin receptors from adipocytes of non-insulin-dependent diabetic subjects

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Insulin receptor tyrosine kinase activity is reduced in monocytes from non-obese normoglycaemic insulin-resistant subjects

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Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease

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Demonstration of insulin resistance in untreated adult onset diabetic subjects with fasting hyperglycemia

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Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases

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7 January 2021

Insulin receptor tyrosine-kinase activity is altered in both muscle and adipose tissue from non-obese normoglycaemic insulin-resistant subjects

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7 January 2021

Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain

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7 January 2021

An extracellular domain of the beta subunit is essential for processing, transport and kinase activity of insulin receptor

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Homozygosity for a new mutation (Ile119-->Met) in the insulin receptor gene in five sibs with familial insulin resistance

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Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha

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7 January 2021

Crystal structure of the tyrosine kinase domain of the human insulin receptor

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7 January 2021

A mutation (Trp1193-->Leu1193) in the tyrosine kinase domain of the insulin receptor associated with type A syndrome of insulin resistance

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7 January 2021

Two mutant alleles of the insulin receptor gene in a patient with extreme insulin resistance.

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Five mutant alleles of the insulin receptor gene in patients with genetic forms of insulin resistance

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The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man.

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7 January 2021

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7 January 2021

Functional properties of a heterozygous mutation (Arg1174-->Gln) in the tyrosine kinase domain of the insulin receptor from a type A insulin resistant patient

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7 January 2021

An in-frame insertion in exon 3 and a nonsense mutation in exon 2 of the insulin receptor gene associated with severe insulin resistance in a patient with Rabson-Mendenhall syndrome

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7 January 2021

Human diabetes associated with a mutation in the tyrosine kinase domain of the insulin receptor

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7 January 2021

Defects in human insulin receptor gene expression

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7 January 2021

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7 January 2021

Defective insulin action in fibroblasts from noninsulin-dependent diabetes mellitus patients with Gln1152 insulin receptor mutation

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1

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7 January 2021

Human diabetes associated with a deletion of the tyrosine kinase domain of the insulin receptor.

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7 January 2021

Leu 193 mutation in the cysteine rich region of the insulin receptor inhibits the cleavage of the insulin receptor precursor but not insulin binding

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7 January 2021

An assessment of human insulin receptor phosphorylation and exogenous kinase activity following deletion of 69 residues from the carboxyl-terminus of the receptor beta-subunit

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7 January 2021

Signal transduction by receptors with tyrosine kinase activity

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7 January 2021

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

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7 January 2021

Patients with lipodystrophic diabetes mellitus of the Seip-Berardinelli type, express normal insulin receptors

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7 January 2021

Molecular analysis of insulin receptor gene in Werner's syndrome.

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7 January 2021

Homozygous deletion of the human insulin receptor gene results in leprechaunism

1 reference

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7 January 2021

Deletion of exon 3 of the insulin receptor gene in a kindred with a familial form of insulin resistance

1 reference

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7 January 2021

Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity

1 reference

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7 January 2021

Ligand-binding properties of the two isoforms of the human insulin receptor

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7 January 2021

10.1016/S0950-351X(96)80330-2

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8734453%20AND%20SRC:MED&resulttype=core&format=json

17 October 2019

1 reference