HNF4A Regulates the Formation of Hepatic Progenitor Cells from Human iPSC-Derived Endoderm by Facilitating Efficient Recruitment of RNA Pol II (Q61811912)

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English	HNF4A Regulates the Formation of Hepatic Progenitor Cells from Human iPSC-Derived Endoderm by Facilitating Efficient Recruitment of RNA Pol II	article

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scholarly article

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16 April 2020

HNF4A Regulates the Formation of Hepatic Progenitor Cells from Human iPSC-Derived Endoderm by Facilitating Efficient Recruitment of RNA Pol II (English)

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16 April 2020

hepatocyte differentiation

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liver development

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Hepatocyte nuclear factor 4 alpha

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GOA release 2020-03-11

positive regulation of transcription by RNA polymerase II

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GOA release 2020-03-11

3

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Stephen A. Duncan

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Ann DeLaForest

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Francesca Di Furio

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16 April 2020

Amy Ludwig-Kubinski

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Kirk Twaroski

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Amanda Urick

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Kirthi Pulakanti

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Sridhar Rao

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28 December 2018

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Creative Commons Attribution 4.0 International

28 December 2018

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April 2022 Public Data File from Crossref

copyright status

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Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the mouse HNF-4 gene and its expression during mouse embryogenesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TFIIB-directed transcriptional activation by the orphan nuclear receptor hepatocyte nuclear factor 4.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The DNA binding domain of hepatocyte nuclear factor 4 mediates cooperative, specific binding to DNA and heterodimerization with the retinoid X receptor alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding of the winged-helix transcription factor HNF3 to a linker histone site on the nucleosome.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional association between CBP and HNF4 in trans-activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GATA transcription factors as potentiators of gut endoderm differentiation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CREB-binding protein is a transcriptional coactivator for hepatocyte nuclear factor-4 and enhances apolipoprotein gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An enhancer element 6 kb upstream of the mouse HNF4alpha1 promoter is activated by glucocorticoids and liver-enriched transcription factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of HNF4alpha isoforms in mouse liver development is regulated by sequential promoter usage and constitutive 3' end splicing

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coordination of PIC Assembly and Chromatin Remodeling During Differentiation-Induced Gene Activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HNF4: A central regulator of hepatocyte differentiation and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatocyte nuclear factor 4alpha controls the development of a hepatic epithelium and liver morphogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of pancreas and liver gene expression by HNF transcription factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The initiation of liver development is dependent on Foxa transcription factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficient differentiation of human embryonic stem cells to definitive endoderm

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defined conditions for development of functional hepatic cells from human embryonic stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation of mice harbouring a conditional loss-of-function allele of Gata6.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatocyte nuclear factor 4alpha is essential for embryonic development of the mouse colon

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatocyte nuclear factor 4alpha orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasticity and expanding complexity of the hepatic transcription factor network during liver development

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two functional modes of a nuclear receptor-recruited arginine methyltransferase in transcriptional activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Directed differentiation of human embryonic stem cells into functional hepatic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue-specific transcriptional regulation has diverged significantly between human and mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cited2, a coactivator of HNF4alpha, is essential for liver development

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficient differentiation of hepatocytes from human embryonic stem cells exhibiting markers recapitulating liver development in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficient differentiation of functional hepatocytes from human embryonic stem cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tbx3 controls the fate of hepatic progenitor cells in liver development by suppressing p19ARF expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crucial role of vHNF1 in vertebrate hepatic specification

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GATA4 is essential for jejunal function in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differentiation and transplantation of human embryonic stem cell-derived hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tbx3 promotes liver bud expansion during mouse development by suppression of cholangiocyte differentiation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of liver development: concepts for understanding liver disorders and design of novel therapies

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integrated approach for the identification of human hepatocyte nuclear factor 4alpha target genes using protein binding microarrays

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Organogenesis and development of the liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation of functional hepatocytes from human embryonic stem cells under chemically defined conditions that recapitulate liver development

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Foxa1 functions as a pioneer transcription factor at transposable elements to activate Afp during differentiation of embryonic stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Five-vertebrate ChIP-seq reveals the evolutionary dynamics of transcription factor binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Culture of human pluripotent stem cells using completely defined conditions on a recombinant E-cadherin substratum

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation of human induced pluripotent stem cells by simple transient transfection of plasmid DNA encoding reprogramming factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HNF4A is essential for specification of hepatic progenitors from human pluripotent stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cistrome: an integrative platform for transcriptional regulation studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pioneer transcription factors: establishing competence for gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a binding motif specific to HNF4 by comparative analysis of multiple nuclear receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatocyte-like cells differentiated from human induced pluripotent stem cells: relevance to cellular therapies

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differentiation of hepatocytes from pluripotent stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activin/nodal signaling and NANOG orchestrate human embryonic stem cell fate decisions by controlling the H3K4me3 chromatin mark.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FGF2 mediates hepatic progenitor cell formation during human pluripotent stem cell differentiation by inducing the WNT antagonist NKD1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A small-molecule screen reveals that HSP90β promotes the conversion of induced pluripotent stem cell-derived endoderm to a hepatic fate and regulates HNF4A turnover.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The use of human pluripotent stem cells for modelling liver development and disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30597922

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3390/GENES10010021

1 reference

Europe PubMed Central

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16 April 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30597922%20AND%20SRC:MED&resulttype=core&format=json

16 April 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30597922%20AND%20SRC:MED&resulttype=core&format=json

16 April 2020

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