Structural insights for the design of new PPARgamma partial agonists with high binding affinity and low transactivation activity (Q61697352)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21691811%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

title

Structural insights for the design of new PPARgamma partial agonists with high binding affinity and low transactivation activity (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21691811%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21691811%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

Miquel Mulero

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21691811%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

Lluís Arola

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21691811%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

Gerard Pujadas

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21691811%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

Santiago Garcia-Vallvé

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21691811%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

author name string

Laura Guasch

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21691811%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

Esther Sala

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21691811%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

Cristina Valls

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21691811%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

publication date

21 June 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21691811%20AND%20SRC:MED&resulttype=core&format=json

Journal of Computer - Aided Molecular Design

5 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21691811%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

volume

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21691811%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

page(s)

717-728

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21691811%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21691811%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1007/s10822-011-9446-9

5 February 2020

exact match

0 references

cites work

Horizontal gene transfer in glycosyl hydrolases inferred from codon usage in Escherichia coli and Bacillus subtilis

1 reference

12 December 2020

PHASE: a new engine for pharmacophore perception, 3D QSAR model development, and 3D database screening: 1. Methodology and preliminary results

1 reference

12 December 2020

Selective PPARgamma modulators with improved pharmacological profiles

1 reference

12 December 2020

Structural insight into PPARgamma ligands binding.

1 reference

12 December 2020

PPAR modulators and PPAR pan agonists for metabolic diseases: the next generation of drugs targeting peroxisome proliferator-activated receptors?

1 reference

12 December 2020

Partial agonists activate PPARgamma using a helix 12 independent mechanism

1 reference

12 December 2020

Characterization of new PPARgamma agonists: benzimidazole derivatives - the importance of position 2.

1 reference

12 December 2020

Synthesis and biological activities of novel aryl indole-2-carboxylic acid analogs as PPARgamma partial agonists

1 reference

12 December 2020

Highly functionalized 7-azaindoles as selective PPAR gamma modulators

1 reference

12 December 2020

Novel method for generating structure-based pharmacophores using energetic analysis

1 reference

12 December 2020

Synthesis and pharmacological evaluation of a new class of peroxisome proliferator-activated receptor modulators

1 reference

12 December 2020

Design, synthesis, and structure-activity relationship studies of novel 2,4,6-trisubstituted-5-pyrimidinecarboxylic acids as peroxisome proliferator-activated receptor gamma (PPARgamma) partial agonists with comparable antidiabetic efficacy to rosig

1 reference

12 December 2020

LigandScout: 3-D pharmacophores derived from protein-bound ligands and their use as virtual screening filters

1 reference

12 December 2020

Molecular basis of selective PPARgamma modulation for the treatment of Type 2 diabetes

1 reference

12 December 2020

Benzoyl 2-methyl indoles as selective PPARgamma modulators

1 reference

12 December 2020

Synthesis and biological activities of novel indole derivatives as potent and selective PPARgamma modulators

1 reference

12 December 2020

Structural basis for the design of PPAR-gamma ligands: a survey on quantitative structure- activity relationships.

1 reference

12 December 2020

Selective PPAR modulators, dual and pan PPAR agonists: multimodal drugs for the treatment of type 2 diabetes and atherosclerosis

1 reference

12 December 2020

New Insights on the mechanism of PPAR-targeted drugs.

1 reference

12 December 2020

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5.

1 reference

12 December 2020

Obesity: New life for antidiabetic drugs

1 reference

12 December 2020

Characterization of new PPARgamma agonists: analysis of telmisartan's structural components

1 reference

12 December 2020

Peroxisome proliferator-activated receptor gamma and metabolic disease.

1 reference

12 December 2020

Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-gamma binding agents with potential application to the treatment of osteoporosis

1 reference

12 December 2020

The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones

1 reference

12 December 2020

Discovery of a novel selective PPARgamma modulator from (-)-Cercosporamide derivatives

1 reference

12 December 2020

Crystal structure of the peroxisome proliferator-activated receptor gamma (PPARgamma) ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug design

1 reference

12 December 2020

Potential remains for PPAR-targeted drugs

1 reference

12 December 2020

Structure-based drug design of a novel family of PPARgamma partial agonists: virtual screening, X-ray crystallography, and in vitro/in vivo biological activities.

1 reference

12 December 2020

Peroxisome proliferator-activated receptor structures: ligand specificity, molecular switch and interactions with regulators.

1 reference

12 December 2020

An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)

1 reference

12 December 2020

Discovery of a peroxisome proliferator activated receptor gamma (PPARgamma) modulator with balanced PPARalpha activity for the treatment of type 2 diabetes and dyslipidemia

1 reference

12 December 2020

The mechanisms of action of PPARs

1 reference

12 December 2020

Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands

1 reference

12 December 2020

10.1007/S10822-011-9446-9

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21691811%20AND%20SRC:MED&resulttype=core&format=json

journals/jcamd/GuaschSVBMAPG11

5 February 2020

DBLP publication ID

1 reference

DBLP Dataset 2021-01-02

28 January 2021

1 reference