Anti-IL-7 receptor α monoclonal antibody (GSK2618960) in healthy subjects - a randomized, double-blind, placebo-controlled study (Q61453292)

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20 April 2020

title

Anti-IL-7 receptor α monoclonal antibody (GSK2618960) in healthy subjects - a randomized, double-blind, placebo-controlled study (English)

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1

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20 April 2020

Andrew Want

8

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Joseph Cheriyan

19

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author name string

Andre van Maurik

2

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Lea Fortunato

3

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Sophie Gisbert

4

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Keguan Chen

5

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Ann Schwartz

6

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Simon McHugh

7

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Sara Santos Franco

9

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Joao-Joaquim Oliveira

10

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Jeffrey Price

11

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Alasdair Coles

12

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Kim Brown

13

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Donggang Su

14

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Jenny L Craigen

15

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Jiansong Yang

16

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Sara Brett

17

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Bill Davis

18

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Onajite Kousin-Ezewu

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Frank Gray

21

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Paul W Thompson

22

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Disala Fernando

23

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language of work or name

English

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publication date

3 December 2018

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British Journal of Clinical Pharmacology

20 April 2020

published in

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volume

85

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page(s)

304-315

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issue

2

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Interleukin 7 induces cytokine secretion and tumoricidal activity by human peripheral blood monocytes

20 April 2020

cites work

1 reference

12 December 2020

Elevated circulating interleukin-7 levels in patients with systemic juvenile rheumatoid arthritis

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12 December 2020

Synergistic effects of IL-7 and IL-12 on human T cell activation.

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12 December 2020

IL-7 differentially modulates the expression of IFN-gamma and IL-4 in activated human T lymphocytes by transcriptional and post-transcriptional mechanisms

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Increased interleukin-7 concentrations in lesional skin and in the sera of patients with plaque-type psoriasis

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Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency

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Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

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12 December 2020

IL-7 is critical for homeostatic proliferation and survival of naive T cells

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Therapeutic antibodies for human diseases at the dawn of the twenty-first century

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12 December 2020

Interleukin 7 stimulates tumour necrosis factor alpha and Th1 cytokine production in joints of patients with rheumatoid arthritis

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12 December 2020

Increased intraarticular interleukin-7 in rheumatoid arthritis patients stimulates cell contact-dependent activation of CD4(+) T cells and macrophages

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12 December 2020

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

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12 December 2020

Ectopic lymphoid-organ development occurs through interleukin 7-mediated enhanced survival of lymphoid-tissue-inducer cells.

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12 December 2020

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

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12 December 2020

Risk alleles for multiple sclerosis identified by a genomewide study

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12 December 2020

Identification of interleukin-7 as a candidate disease mediator in spondylarthritis

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12 December 2020

Increased expression of interleukin-7 in labial salivary glands of patients with primary Sjögren's syndrome correlates with increased inflammation

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12 December 2020

Thymic stromal lymphopoietin

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12 December 2020

Blockade of the interleukin-7 receptor inhibits collagen-induced arthritis and is associated with reduction of T cell activity and proinflammatory mediators.

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12 December 2020

Expansion of human NK-22 cells with IL-7, IL-2, and IL-1beta reveals intrinsic functional plasticity

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12 December 2020

IL-7 promotes T(H)1 development and serum IL-7 predicts clinical response to interferon-β in multiple sclerosis

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12 December 2020

Cytokine signals through PI-3 kinase pathway modulate Th17 cytokine production by CCR6+ human memory T cells

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12 December 2020

The IL-7Rα pathway is quantitatively and functionally altered in CD8 T cells in multiple sclerosis.

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12 December 2020

IL-7 drives Th1 and Th17 cytokine production in patients with primary SS despite an increase in CD4 T cells lacking the IL-7Rα

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12 December 2020

Increased interleukin (IL)-7Rα expression in salivary glands of patients with primary Sjogren's syndrome is restricted to T cells and correlates with IL-7 expression, lymphocyte numbers and activity

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12 December 2020

Immunogenicity to therapeutic proteins: impact on PK/PD and efficacy

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12 December 2020

IL-7 signaling and CD127 receptor regulation in the control of T cell homeostasis

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12 December 2020

IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells.

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12 December 2020

Anti-IL-7 receptor-α reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function

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12 December 2020

Interleukin-7 receptor blockade suppresses adaptive and innate inflammatory responses in experimental colitis

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12 December 2020

Exposure-response relationship of tocilizumab, an anti-IL-6 receptor monoclonal antibody, in a large population of patients with rheumatoid arthritis

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12 December 2020

Soluble IL7Rα potentiates IL-7 bioactivity and promotes autoimmunity

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12 December 2020

Interleukin-7 enhances the Th1 response to promote the development of Sjögren's syndrome-like autoimmune exocrinopathy in mice

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12 December 2020

Interleukin-7: Fuel for the autoimmune attack.

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12 December 2020

The genetic variants of thymic stromal lymphopoietin protein in children with asthma and allergic rhinitis.

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12 December 2020

Interleukin-7 and Toll-like receptor 7 induce synergistic B cell and T cell activation

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12 December 2020

Effects of an anti-TSLP antibody on allergen-induced asthmatic responses

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12 December 2020

Receptor occupancy and blocking of STAT5 signaling by an anti-IL-7 receptor α antibody in cynomolgus monkeys

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12 December 2020

Measurement of anti-drug antibodies to biologic drugs

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12 December 2020

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Voltage-gated ion channels.

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12 December 2020

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Catalytic receptors

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12 December 2020

The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY.

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12 December 2020

Identifiers

DOI

10.1111/BCP.13748

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20 April 2020

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