CTC1-STN1 terminates telomerase while STN1-TEN1 enables C-strand synthesis during telomere replication in colon cancer cells (Q61136030)

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13 April 2020

title

CTC1-STN1 terminates telomerase while STN1-TEN1 enables C-strand synthesis during telomere replication in colon cancer cells (English)

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13 April 2020

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Anukana Bhattacharjee

3

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13 April 2020

Jiajie Diao

5

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13 April 2020

author name string

Xuyang Feng

1

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13 April 2020

Shih-Jui Hsu

2

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13 April 2020

Yongyao Wang

4

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13 April 2020

Carolyn M Price

6

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13 April 2020

language of work or name

English

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publication date

19 July 2018

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13 April 2020

published in

Nature Communications

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13 April 2020

volume

9

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13 April 2020

issue

1

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13 April 2020

page(s)

2827

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describes a project that uses

13 April 2020

ImageQuant

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11 June 2022

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inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/s41467-018-05154-z

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cites work

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Telomerase Mechanism of Telomere Synthesis

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CTC1-mediated C-strand fill-in is an essential step in telomere length maintenance

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Human CST has independent functions during telomere duplex replication and C-strand fill-in

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Replicating through telomeres: a means to an end.

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Early and late steps in telomere overhang processing in normal human cells: the position of the final RNA primer drives telomere shortening

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Telomeric 3' overhangs derive from resection by Exo1 and Apollo and fill-in by POT1b-associated CST.

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Control of telomerase action at human telomeres

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Live Cell Imaging Reveals the Dynamics of Telomerase Recruitment to Telomeres

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Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation

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Telomere extension occurs at most chromosome ends and is uncoupled from fill-in in human cancer cells

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The human CST complex is a terminator of telomerase activity

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Xenopus laevis Ctc1-Stn1-Ten1 (xCST) protein complex is involved in priming DNA synthesis on single-stranded DNA template in Xenopus egg extract

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7 January 2021

A DNA polymerase-{alpha}⋅primase cofactor with homology to replication protein A-32 regulates DNA replication in mammalian cells

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7 January 2021

STN1-POLA2 interaction provides a basis for primase-pol α stimulation by human STN1.

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7 January 2021

Human CST abundance determines recovery from diverse forms of DNA damage and replication stress

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7 January 2021

Human CST promotes telomere duplex replication and general replication restart after fork stalling

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7 January 2021

Human CST Facilitates Genome-wide RAD51 Recruitment to GC-Rich Repetitive Sequences in Response to Replication Stress

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7 January 2021

Dynamic DNA binding, junction recognition and G4 melting activity underlie the telomeric and genome-wide roles of human CST.

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STN1 OB Fold Mutation Alters DNA Binding and Affects Selective Aspects of CST Function.

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A dynamic model for replication protein A (RPA) function in DNA processing pathways

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Replication protein A: single-stranded DNA's first responder: dynamic DNA-interactions allow replication protein A to direct single-strand DNA intermediates into different pathways for synthesis or repair

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Dynamic binding of replication protein a is required for DNA repair

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7 January 2021

Diffusion of human replication protein A along single-stranded DNA.

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7 January 2021

Structure of the Human Telomeric Stn1-Ten1 Capping Complex

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7 January 2021

Telomere capping proteins are structurally related to RPA with an additional telomere-specific domain

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7 January 2021

Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres

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7 January 2021

CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion

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7 January 2021

Human TEN1 maintains telomere integrity and functions in genome-wide replication restart

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7 January 2021

Human Stn1 protects telomere integrity by promoting efficient lagging-strand synthesis at telomeres and mediating C-strand fill-in

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7 January 2021

Telomere length homeostasis requires that telomerase levels are limiting

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7 January 2021

Human telomerase RNA accumulation in Cajal bodies facilitates telomerase recruitment to telomeres and telomere elongation

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7 January 2021

TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends

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7 January 2021

RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway

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7 January 2021

Molecular basis of telomere syndrome caused by CTC1 mutations

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7 January 2021

Human CST Prefers G-Rich but Not Necessarily Telomeric Sequences.

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7 January 2021

POT1-TPP1 regulates telomeric overhang structural dynamics.

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7 January 2021

Structure and conformational change of a replication protein A heterotrimer bound to ssDNA

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7 January 2021

A Shld1-controlled POT1a provides support for repression of ATR signaling at telomeres through RPA exclusion

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7 January 2021

Specific DNA replication mutations affect telomere length in Saccharomyces cerevisiae

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7 January 2021

Alterations of DNA and chromatin structures at telomeres and genetic instability in mouse cells defective in DNA polymerase alpha

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7 January 2021

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7 January 2021

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7 January 2021

POT1a and components of CST engage telomerase and regulate its activity in Arabidopsis

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7 January 2021

SUMOylation regulates telomere length by targeting the shelterin subunit Tpz1(Tpp1) to modulate shelterin-Stn1 interaction in fission yeast

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7 January 2021

Tpz1TPP1 SUMOylation reveals evolutionary conservation of SUMO-dependent Stn1 telomere association

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7 January 2021

Sequential phosphorylation of CST subunits by different cyclin-Cdk1 complexes orchestrate telomere replication.

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7 January 2021

Phosphorylation of TPP1 regulates cell cycle-dependent telomerase recruitment

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7 January 2021

Protein dynamics of human RPA and RAD51 on ssDNA during assembly and disassembly of the RAD51 filament

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7 January 2021

An emerging role for the conserved telomere component 1 (CTC1) in human genetic disease

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7 January 2021

Mutations in STN1 cause Coats plus syndrome and are associated with genomic and telomere defects.

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7 January 2021

Telomeres shorten during ageing of human fibroblasts

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7 January 2021

Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions.

1 reference

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7 January 2021

The mechanism of action of an accessory protein for DNA polymerase alpha/primase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/30026550

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/S41467-018-05154-Z

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30026550%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

13 April 2020

ADS bibcode

2018NatCo...9.2827F

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13 April 2020

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