Spray-applied cell therapy with human allogeneic fibroblasts and keratinocytes for the treatment of chronic venous leg ulcers: a phase 2, multicentre, double-blind, randomised, placebo-controlled trial (Q61051157)

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scientific article published in The Lancet

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English	Spray-applied cell therapy with human allogeneic fibroblasts and keratinocytes for the treatment of chronic venous leg ulcers: a phase 2, multicentre, double-blind, randomised, placebo-controlled trial	scientific article published in The Lancet

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scholarly article

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9 February 2020

Spray-applied cell therapy with human allogeneic fibroblasts and keratinocytes for the treatment of chronic venous leg ulcers: a phase 2, multicentre, double-blind, randomised, placebo-controlled trial (English)

1 reference

Europe PubMed Central

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9 February 2020

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phase II clinical trial

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multicenter clinical trial

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based on heuristic

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placebo-controlled trial

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Robert S. Kirsner

1

object named as

Robert S Kirsner

1 reference

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9 February 2020

author name string

William A Marston

2

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9 February 2020

Robert J Snyder

3

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9 February 2020

Tommy D Lee

4

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9 February 2020

D Innes Cargill

5

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9 February 2020

Herbert B Slade

6

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9 February 2020

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publication date

3 August 2012

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9 February 2020

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9 February 2020

380

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9 February 2020

9846

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9 February 2020

977-985

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9 February 2020

Chronic venous insufficiency and venous leg ulceration

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960644-8

7 January 2021

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Venous leg ulcer: incidence and prevalence in the elderly

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960644-8

7 January 2021

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Comparison of surgery and compression with compression alone in chronic venous ulceration (ESCHAR study): randomised controlled trial.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960644-8

7 January 2021

based on heuristic

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A gene signature of nonhealing venous ulcers: potential diagnostic markers

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960644-8

7 January 2021

based on heuristic

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Treatment of chronic venous ulcers with sheets of cultured allogenic keratinocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960644-8

7 January 2021

based on heuristic

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Tissue-engineered skin. Current status in wound healing

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960644-8

7 January 2021

based on heuristic

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Clinical and economic outcomes with graftskin for hard-to-heal venous leg ulcers: a single-center experience

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960644-8

7 January 2021

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Rapid healing of venous ulcers and lack of clinical rejection with an allogeneic cultured human skin equivalent. Human Skin Equivalent Investigators Group

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960644-8

7 January 2021

based on heuristic

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Keratinocyte grafting: a new means of transplantation for full-thickness wounds

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960644-8

7 January 2021

based on heuristic

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Allogenic keratinocytes suspended in human fibrin glue used for wound healing support in chronic leg ulcers

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960644-8

7 January 2021

based on heuristic

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Cultured keratinocytes and keratinocyte grafts

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960644-8

7 January 2021

based on heuristic

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Wound stimulation by growth-arrested human keratinocytes and fibroblasts: HP802-247, a new-generation allogeneic tissue engineering product

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960644-8

7 January 2021

based on heuristic

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Transplantation studies on sheets of pure epidermal epithelium and on epidermal cell suspensions

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960644-8

7 January 2021

based on heuristic

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Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960644-8

7 January 2021

based on heuristic

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An autologous epidermal equivalent tissue-engineered from follicular outer root sheath keratinocytes is as effective as split-thickness skin autograft in recalcitrant vascular leg ulcers

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960644-8

7 January 2021

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Epidermal keratinocytes do not activate peripheral T-cells: interleukin-10 as a possible regulator

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960644-8

7 January 2021

based on heuristic

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Influence of bioengineered skin substitutes on diabetic foot ulcer and venous leg ulcer outcomes

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960644-8

7 January 2021

based on heuristic

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Improving venous ulcer healing: designing and reporting randomised controlled trials

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960644-8

7 January 2021

based on heuristic

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Randomized clinical trial of four-layer and short-stretch compression bandages for venous leg ulcers (VenUS I).

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960644-8

7 January 2021

based on heuristic

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Risk factors associated with the failure of a venous leg ulcer to heal

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960644-8

7 January 2021

based on heuristic

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Pharmacologic enhancement of wound healing

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960644-8

7 January 2021

based on heuristic

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A review of a bi-layered living cell treatment (Apligraf) in the treatment of venous leg ulcers and diabetic foot ulcers

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960644-8

7 January 2021

based on heuristic

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Pathway analysis of senescence-associated miRNA targets reveals common processes to different senescence induction mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960644-8

7 January 2021

based on heuristic

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Fibroblast dysfunction is a key factor in the non-healing of chronic venous leg ulcers.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960644-8

7 January 2021

based on heuristic

inferred from DOI database lookup

The senescence-associated secretory phenotype: the dark side of tumor suppression

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960644-8

7 January 2021

based on heuristic

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Venous ulcer fibroblasts respond to basic fibroblast growth factor at the cell cycle protein level

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960644-8

7 January 2021

based on heuristic

inferred from DOI database lookup

A fragment of secreted Hsp90α carries properties that enable it to accelerate effectively both acute and diabetic wound healing in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960644-8

7 January 2021

based on heuristic

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Molecular mechanisms of late apoptotic/necrotic cell clearance

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960644-8

7 January 2021

based on heuristic

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Potential relevance of bell-shaped and u-shaped dose-responses for the therapeutic targeting of angiogenesis in cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960644-8

7 January 2021

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Identifiers

10.1016/S0140-6736(12)60644-8

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863328%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863328%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

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