Adjuvants Enhancing Cross-Presentation by Dendritic Cells: The Key to More Effective Vaccines? (Q60956640)

Europe PubMed Central

2 October 2020

Europe PubMed Central

1 November 2020

Europe PubMed Central

11 December 2020

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12 December 2020

Genetically-engineered subunit vaccine against feline leukaemia virus: protective immune response in cats

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12 December 2020

Separation and characterization of saponins with adjuvant activity from Quillaja saponaria Molina cortex

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Class I-restricted processing and presentation of exogenous cell-associated antigen in vivo

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Saponin adjuvants. 3. Isolation of a substance from Quillaja saponaria Molina with adjuvant activity in food-and-mouth disease vaccines.

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Iscom, a novel structure for antigenic presentation of membrane proteins from enveloped viruses.

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Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens

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A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules

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Adjuvant activity of non-toxic Quillaja saponaria Molina components for use in ISCOM matrix

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12 December 2020

Effects of carbohydrate modification of Quillaja saponaria Molina QH-B fraction on adjuvant activity, cholesterol-binding capacity and toxicity

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12 December 2020

Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen

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12 December 2020

CD8(+) but not CD8(-) dendritic cells cross-prime cytotoxic T cells in vivo.

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12 December 2020

Cutting Edge: Intravenous Soluble Antigen Is Presented to CD4 T Cells by CD8- Dendritic Cells, but Cross-Presented to CD8 T Cells by CD8+ Dendritic Cells

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Antigen presentation capacity and cytokine production by murine splenic dendritic cell subsets upon Salmonella encounter

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12 December 2020

Constitutive versus activation-dependent cross-presentation of immune complexes by CD8(+) and CD8(-) dendritic cells in vivo

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12 December 2020

Protective immunity induced with malaria vaccine, RTS,S, is linked to Plasmodium falciparum circumsporozoite protein-specific CD4+ and CD8+ T cells producing IFN-gamma

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12 December 2020

Control of cross-presentation during dendritic cell maturation

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12 December 2020

NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

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12 December 2020

Recombinant NY-ESO-1 protein with ISCOMATRIX adjuvant induces broad integrated antibody and CD4+ and CD8+ T cell responses in humans

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12 December 2020

Important role of cathepsin S in generating peptides for TAP-independent MHC class I crosspresentation in vivo

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12 December 2020

Toll-like receptor control of the adaptive immune responses

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12 December 2020

Liposome-encapsulated CpG oligodeoxynucleotides as a potent adjuvant for inducing type 1 innate immunity

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12 December 2020

ISCOM-based vaccines: the second decade.

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12 December 2020

Pathogen recognition and innate immunity

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12 December 2020

Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1

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12 December 2020

The dominant role of CD8+ dendritic cells in cross-presentation is not dictated by antigen capture

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12 December 2020

Role of immunoproteasomes in cross-presentation

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12 December 2020

NOX2 Controls Phagosomal pH to Regulate Antigen Processing during Crosspresentation by Dendritic Cells

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Synergy between In situ Cryoablation and TLR9 Stimulation Results in a Highly Effective In vivo Dendritic Cell Vaccine

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A role for the endoplasmic reticulum protein retrotranslocation machinery during crosspresentation by dendritic cells

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12 December 2020

Differential antigen processing by dendritic cell subsets in vivo

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12 December 2020

Cooperation of Toll-like receptor signals in innate immune defence

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12 December 2020

Activation of dendritic cells and induction of CD4(+) T cell differentiation by aluminum-containing adjuvants

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12 December 2020

CD8– dendritic cells preferentially cross-presentSaccharomyces cerevisiae antigens

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12 December 2020

Selective suicide of cross-presenting CD8+ dendritic cells by cytochrome c injection shows functional heterogeneity within this subset

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12 December 2020

Direct proteasome-independent cross-presentation of viral antigen by plasmacytoid dendritic cells on major histocompatibility complex class I.

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12 December 2020

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

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12 December 2020

Cutting edge: inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3.

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12 December 2020

Clearance of influenza virus from the lung depends on migratory langerin+CD11b- but not plasmacytoid dendritic cells

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12 December 2020

In vivo colocalization of antigen and CpG [corrected] within dendritic cells is associated with the efficacy of cancer immunotherapy

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12 December 2020

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

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12 December 2020

Molecular and cellular signatures of human vaccine adjuvants.

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12 December 2020

Plasmacytoid dendritic cells efficiently cross-prime naive T cells in vivo after TLR activation.

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12 December 2020

Batf3 Deficiency Reveals a Critical Role for CD8 + Dendritic Cells in Cytotoxic T Cell Immunity

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12 December 2020

Differential roles of migratory and resident DCs in T cell priming after mucosal or skin HSV-1 infection

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12 December 2020

ISCOMATRIX adjuvant induces efficient cross-presentation of tumor antigen by dendritic cells via rapid cytosolic antigen delivery and processing via tripeptidyl peptidase II.

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12 December 2020

Advances in saponin-based adjuvants

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12 December 2020

Innovative strategies for co-delivering antigens and CpG oligonucleotides

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12 December 2020

The small GTPase Rac2 controls phagosomal alkalinization and antigen crosspresentation selectively in CD8(+) dendritic cells

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12 December 2020

Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells

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12 December 2020

Immunogenicity and safety of low dose virosomal adjuvanted influenza vaccine administered intradermally compared to intramuscular full dose administration

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12 December 2020

IRAP identifies an endosomal compartment required for MHC class I cross-presentation

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12 December 2020

A role for lipid bodies in the cross-presentation of phagocytosed antigens by MHC class I in dendritic cells

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12 December 2020

The GTPase Rab3b/3c-positive recycling vesicles are involved in cross-presentation in dendritic cells

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12 December 2020

AS04, an aluminum salt- and TLR4 agonist-based adjuvant system, induces a transient localized innate immune response leading to enhanced adaptive immunity

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12 December 2020

Using 3 TLR ligands as a combination adjuvant induces qualitative changes in T cell responses needed for antiviral protection in mice

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12 December 2020

Processing and cross-presentation of individual HLA-A, -B, or -C epitopes from NY-ESO-1 or an HLA-A epitope for Melan-A differ according to the mode of antigen delivery

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12 December 2020

Nomenclature of monocytes and dendritic cells in blood.

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12 December 2020

First in humans: a new molecularly defined vaccine shows excellent safety and strong induction of long-lived Mycobacterium tuberculosis-specific Th1-cell like responses

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12 December 2020

Adjuvant System AS03 containing α-tocopherol modulates innate immune response and leads to improved adaptive immunity.

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12 December 2020

Recent clinical experience with vaccines using MPL- and QS-21-containing adjuvant systems

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12 December 2020

ISCOMATRIX adjuvant combines immune activation with antigen delivery to dendritic cells in vivo leading to effective cross-priming of CD8+ T cells.

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12 December 2020

Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells

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12 December 2020

Immunological mechanisms of vaccination

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12 December 2020

CD103+ pulmonary dendritic cells preferentially acquire and present apoptotic cell-associated antigen

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12 December 2020

ISCOMATRIX vaccines mediate CD8+ T-cell cross-priming by a MyD88-dependent signaling pathway

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12 December 2020

Circumsporozoite-specific T cell responses in children vaccinated with RTS,S/AS01E and protection against P falciparum clinical malaria

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12 December 2020

Sec22b regulates phagosomal maturation and antigen crosspresentation by dendritic cells

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12 December 2020

Zinc finger transcription factor zDC is a negative regulator required to prevent activation of classical dendritic cells in the steady state

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12 December 2020

Human plasmacytoid dendritic cells efficiently cross-present exogenous Ags to CD8+ T cells despite lower Ag uptake than myeloid dendritic cell subsets.

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12 December 2020

Targeting antigen to bone marrow stromal cell-2 expressed by conventional and plasmacytoid dendritic cells elicits efficient antigen presentation

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12 December 2020

Targeting dendritic cells--why bother?

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12 December 2020

Antigen cross-presentation by dendritic cell subsets: one general or all sergeants?

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12 December 2020

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12 December 2020

Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses

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An overview of adjuvant formulations and delivery systems.

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Dendritic cell maturation: functional specialization through signaling specificity and transcriptional programming

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Synergistic anticancer effects of Pam3CSK4 and Ara-C on B-cell lymphoma cells

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Therapeutic in situ autovaccination against solid cancers with intratumoral poly-ICLC: case report, hypothesis, and clinical trial

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Development and function of dendritic cell subsets

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12 December 2020

Enhancement of adaptive immunity by the human vaccine adjuvant AS01 depends on activated dendritic cells

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12 December 2020

Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny

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12 December 2020

TLR signals induce phagosomal MHC-I delivery from the endosomal recycling compartment to allow cross-presentation

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12 December 2020

The mechanisms of action of vaccines containing aluminum adjuvants: an in vitro vs in vivo paradigm.

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12 December 2020

The translocon protein Sec61 mediates antigen transport from endosomes in the cytosol for cross-presentation to CD8(+) T cells

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12 December 2020

Vaccines, Adjuvants, and Dendritic Cell Activators--Current Status and Future Challenges

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12 December 2020

Identification of QS-21 as an Inflammasome-activating Molecular Component of Saponin Adjuvants

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12 December 2020

Toll-like Receptor 4 Engagement on Dendritic Cells Restrains Phago-Lysosome Fusion and Promotes Cross-Presentation of Antigens

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12 December 2020

Different human vaccine adjuvants promote distinct antigen-independent immunological signatures tailored to different pathogens

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12 December 2020

Lipid peroxidation causes endosomal antigen release for cross-presentation

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12 December 2020

Matrix-M adjuvant enhances antibody, cellular and protective immune responses of a Zaire Ebola/Makona virus glycoprotein (GP) nanoparticle vaccine in mice

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12 December 2020

Vaccines for established cancer: overcoming the challenges posed by immune evasion

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12 December 2020

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

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12 December 2020

Saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation

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12 December 2020

Lysosome-Dependent Activation of Human Dendritic Cells by the Vaccine Adjuvant QS-21.

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12 December 2020

C1q-Dependent Dendritic Cell Cross-Presentation of In Vivo-Formed Antigen-Antibody Complexes.

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12 December 2020

Mapping the human DC lineage through the integration of high-dimensional techniques.

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12 December 2020

A Critical Analysis of the Role of SNARE Protein SEC22B in Antigen Cross-Presentation.

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12 December 2020

Critical role for Sec22b-dependent antigen cross-presentation in antitumor immunity.

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12 December 2020

An Overview of Novel Adjuvants Designed for Improving Vaccine Efficacy

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12 December 2020

Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer.

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12 December 2020

Sec61 blockade by mycolactone inhibits antigen cross-presentation independently of endosome-to-cytosol export

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12 December 2020

MHC Class I Cross-Presentation: Stage Lights on Sec22b

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12 December 2020

TLR Agonists as Adjuvants for Cancer Vaccines.

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12 December 2020

UNC93B1 interacts with the calcium sensor STIM1 for efficient antigen cross-presentation in dendritic cells.

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12 December 2020

STIM1 promotes migration, phagosomal maturation and antigen cross-presentation in dendritic cells.

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12 December 2020

Turning the Old Adjuvant from Gel to Nanoparticles to Amplify CD8+ T Cell Responses.

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12 December 2020

Vx3-Functionalized Alumina Nanoparticles Assisted Enrichment of Ubiquitinated Proteins from Cancer Cells for Enhanced Cancer Immunotherapy.

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12 December 2020

Lipid Droplets as Immune Modulators in Myeloid Cells

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12 December 2020

Elucidating the Mechanisms of Action of Saponin-Derived Adjuvants

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12 December 2020

Correlates of adjuvanticity: A review on adjuvants in licensed vaccines

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12 December 2020

Mitochondrial reactive oxygen species regulate the induction of CD8+ T cells by plasmacytoid dendritic cells.

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12 December 2020

Polyethyleneimine modification of aluminum hydroxide nanoparticle enhances antigen transportation and cross-presentation of dendritic cells.

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12 December 2020

Human in vivo-generated monocyte-derived dendritic cells and macrophages cross-present antigens through a vacuolar pathway.

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12 December 2020

Current Concepts of Antigen Cross-Presentation

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12 December 2020

Modulation of Vaccine-Induced CD4 T Cell Functional Profiles by Changes in Components of HIV Vaccine Regimens in Humans

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Targeting Toll-Like Receptors for Cancer Therapy

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12 December 2020