A Dual Role of Heme Oxygenase-1 in Cancer Cells (Q60939671)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Reactive oxygen species in cancer

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Modulation of oxidative stress as an anticancer strategy

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Cancer cell killing via ROS: to increase or decrease, that is the question

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Ferroptosis: an iron-dependent form of nonapoptotic cell death

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Regulation of ferroptotic cancer cell death by GPX4

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

HO-1/CO system in tumor growth, angiogenesis and metabolism - Targeting HO-1 as an anti-tumor therapy

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

HO-1 Induction in Cancer Progression: A Matter of Cell Adaptation

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Mechanisms of cell protection by heme oxygenase-1.

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Heme Oxygenase 1 as a Therapeutic Target in Acute Kidney Injury

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Heme Oxygenase 1 in the Nervous System: Does It Favor Neuronal Cell Survival or Induce Neurodegeneration?

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Heme oxygenase-1 mediates BAY 11-7085 induced ferroptosis.

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Mechanisms of ferroptosis

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Ferroptosis: process and function

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Oxidative stress inhibits distant metastasis by human melanoma cells

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

The Role of Ferroptosis in Cancer Development and Treatment Response.

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

The xc- cystine/glutamate antiporter: a mediator of pancreatic cancer growth with a role in drug resistance

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

The heme catabolic pathway and its protective effects on oxidative stress-mediated diseases.

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Pharmacological and clinical aspects of heme oxygenase

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Heme Oxygenase-1 Mitigates Ferroptosis in Renal Proximal Tubule Cells.

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Magnesium isoglycyrrhizinate ameliorates liver fibrosis and hepatic stellate cell activation by regulating ferroptosis signaling pathway

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Metals, oxidative stress and neurodegenerative disorders

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Heme oxygenase-1 induction and dependent increase in ferritin. A protective antioxidant stratagem in hemin-treated rat brain

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Endoplasmic reticulum anchored heme-oxygenase 1 faces the cytosol

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Heme oxygenase-1 protein localizes to the nucleus and activates transcription factors important in oxidative stress

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

HO-1 is located in liver mitochondria and modulates mitochondrial heme content and metabolism

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Heme oxygenase-1 induction by NRF2 requires inactivation of the transcriptional repressor BACH1.

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Depletion of reduced glutathione enhances motor neuron degeneration in vitro and in vivo

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Ubiquitin-proteasome system mediates heme oxygenase-1 degradation through endoplasmic reticulum-associated degradation pathway

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Degradation of heme oxygenase-1 by the immunoproteasome in astrocytes: A potential interferon-γ-dependent mechanism contributing to HIV neuropathogenesis.

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Preservation solution supplemented with biliverdin prevents lung cold ischaemia/reperfusion injury.

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Role of heme oxygenase in preserving vascular bioactive NO.

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Heme oxygenase-1 inhibits apoptosis in Caco-2 cells via activation of Akt pathway

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Biliverdin's regulation of reactive oxygen species signalling leads to potent inhibition of proliferative and angiogenic pathways in head and neck cancer

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Bilirubin inhibits tumor cell growth via activation of ERK.

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Hyperbilirubinemia, hemolysis, and increased bilirubin neurotoxicity

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Iron metabolism and toxicity

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Gene transfection of H25A mutant heme oxygenase-1 protects cells against hydroperoxide-induced cytotoxicity

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Iron in multiple sclerosis: roles in neurodegeneration and repair

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Non-protein-bound iron detection in small samples of biological fluids and tissues.

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Intracellular iron transport and storage: from molecular mechanisms to health implications

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Lysosomal proteolysis is the primary degradation pathway for cytosolic ferritin and cytosolic ferritin degradation is necessary for iron exit.

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Iron-regulatory proteins: molecular biology and pathophysiological implications

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Haem oxygenase-1 overexpression alters intracellular iron distribution

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Salinomycin kills cancer stem cells by sequestering iron in lysosomes.

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Ferroptosis is an autophagic cell death process

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Haem oxygenase shows pro-oxidant activity in microsomal and cellular systems: implications for the release of low-molecular-mass iron.

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Dynamics of haem oxygenase-1 expression and bilirubin production in cellular protection against oxidative stress.

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Reversal of HO-1 related cytoprotection with increased expression is due to reactive iron.

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Acute iron overload and oxidative stress in brain

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Lipid metabolite involvement in the activation of the human heme oxygenase-1 gene

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

The Role of Reactive Oxygen Species and Ferroptosis in Heme-Mediated Activation of Human Platelets

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Heme enzyme structure and function

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Cardiovascular complications and risk of death in sickle-cell disease

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Induction of ferritin synthesis in human lung epithelial cells treated with crocidolite asbestos

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

p62/SQSTM1: a missing link between protein aggregates and the autophagy machinery

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Drug-induced hepatotoxicity in cancer patients - implication for treatment

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Cellular and molecular functions of hepatic stellate cells in inflammatory responses and liver immunology

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Amelioration of Ethanol-Induced Hepatitis by Magnesium Isoglycyrrhizinate through Inhibition of Neutrophil Cell Infiltration and Oxidative Damage

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Artesunate activates mitochondrial apoptosis in breast cancer cells via iron-catalyzed lysosomal reactive oxygen species production

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Antimalarial action of artesunate involves DNA damage mediated by reactive oxygen species

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Mitochondria-targeted heme oxygenase-1 induces oxidative stress and mitochondrial dysfunction in macrophages, kidney fibroblasts and in chronic alcohol hepatotoxicity

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Heme oxygenase-1 regulates mitochondrial quality control in the heart.

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Molecular targets and mechanisms of cancer prevention and treatment by withaferin a, a naturally occurring steroidal lactone

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Withaferin-A--A Natural Anticancer Agent with Pleitropic Mechanisms of Action

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Withaferin A induces heme oxygenase (HO-1) expression in endothelial cells via activation of the Keap1/Nrf2 pathway

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Implication of heme oxygenase-1 in the sensitivity of nasopharyngeal carcinomas to radiotherapy

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Heme oxygenase-1 and its metabolites affect pancreatic tumor growth in vivo

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Heme oxygenase-1 promotes survival of renal cancer cells through modulation of apoptosis- and autophagy-regulating molecules

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

The expression, function and targeting of haem oxygenase-1 in cancer.

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Heme oxygenase-1 nuclear translocation regulates bortezomibinduced cytotoxicity and mediates genomic instability in myeloma cells

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Heme oxygenase-1: A new druggable target in the management of chronic and acute myeloid leukemia.

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Upregulation Is a Mutual Marker in Human Tumor Cells Exposed to Physical Plasma-Derived Oxidants

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Oncogenic potential of Nrf2 and its principal target protein heme oxygenase-1.

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Imidazole-dioxolane compounds as isozyme-selective heme oxygenase inhibitors

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Metalloporphyrins - an update

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Novel Structural Insight into Inhibitors of Heme Oxygenase-1 (HO-1) by New Imidazole-Based Compounds: Biochemical and In Vitro Anticancer Activity Evaluation

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Targeting of heat shock protein 32 (Hsp32)/heme oxygenase-1 (HO-1) in leukemic cells in chronic myeloid leukemia: a novel approach to overcome resistance against imatinib

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Low expression of GFI-1 Gene is associated with Panobinostat-resistance in acute myeloid leukemia through influencing the level of HO-1.

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Enhancement of chemotherapeutic response of tumor cells by a heme oxygenase inhibitor, pegylated zinc protoporphyrin.

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Zinc protoporphyrin IX enhances chemotherapeutic response of hepatoma cells to cisplatin

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Inhibition of heme oxygenase-1 enhances the chemosensitivity of laryngeal squamous cell cancer Hep-2 cells to cisplatin

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Inhibition of heme oxygenase-1 increases responsiveness of melanoma cells to ALA-based photodynamic therapy.

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Inhibition of heme oxygenase-1 by zinc protoporphyrin IX reduces tumor growth of LL/2 lung cancer in C57BL mice

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

ZnPPIX inhibits peritoneal metastasis of gastric cancer via its antiangiogenic activity

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Selective inhibition of heme oxygenase, without inhibition of nitric oxide synthase or soluble guanylyl cyclase, by metalloporphyrins at low concentrations.

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Selectivity of imidazole-dioxolane compounds for in vitro inhibition of microsomal haem oxygenase isoforms

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Heme oxygenase inhibition in cancers: possible tools and targets.

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Structural characterization of human heme oxygenase-1 in complex with azole-based inhibitors

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Novel imidazole derivatives as heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2) inhibitors and their cytotoxic activity in human-derived cancer cell lines.

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Targeting heme Oxygenase-1 with hybrid compounds to overcome Imatinib resistance in chronic myeloid leukemia cell lines

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Suppression of Nrf2-driven heme oxygenase-1 enhances the chemosensitivity of lung cancer A549 cells toward cisplatin

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Potential crosstalk of Ca2+-ROS-dependent mechanism involved in apoptosis of Kasumi-1 cells mediated by heme oxygenase-1 small interfering RNA.

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Evaluation of HO-1 expression, cellular ROS production, cellular proliferation and cellular apoptosis in human esophageal squamous cell carcinoma tumors and cell lines

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Knockdown of heme oxygenase-1 promotes apoptosis and autophagy and enhances the cytotoxicity of doxorubicin in breast cancer cells

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Inhibition of heme oxygenase-1 increases responsiveness of pancreatic cancer cells to anticancer treatment

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

The inhibition of heme oxygenase-1 enhances the chemosensitivity and suppresses the proliferation of pancreatic cancer cells through the SHH signaling pathway

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Inhibition of heme oxygenase 1 expression by small interfering RNA decreases orthotopic tumor growth in livers of mice.

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Epigenetic modification of Nrf2 in 5-fluorouracil-resistant colon cancer cells: involvement of TET-dependent DNA demethylation

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503

Pharmacological versus genetic inhibition of heme oxygenase-1 - the comparison of metalloporphyrins, shRNA and CRISPR/Cas9 system.

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337503