Parallel Post-Polyketide Synthase Modification Mechanism Involved in FD-891 Biosynthesis inStreptomyces graminofaciensA-8890 (Q60152012)

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1 March 2020

title

Parallel Post-Polyketide Synthase Modification Mechanism Involved in FD-891 Biosynthesis in Streptomyces graminofaciens A-8890 (English)

1 reference

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Streptomyces graminofaciens

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main subject

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Streptomyces halstedii

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(3E,5E,7R,8R,9E,13E,16S)-16-[(E,2S,7S,8R,9R,10S,11S)-7,9-dihydroxy-11-methoxy-8,10-dimethyldodec-4-en-2-yl]-8-hydroxy-3,5,7-trimethyl-1-oxacyclohexadeca-3,5,9,13-tetraen-2-one

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(1S,2S,3R,4Z,6Z,10S,12Z,14Z)-10-[(5S,6R,7R,8S,9S)-5,7-Dihydroxy-9-methoxy-6,8-dimethyldecan-2-YL]-2,17-dihydroxy-3,5,7-trimethyl-9,19-dioxabicyclo[16.1.0]nonadeca-4,6,12,14-tetraen-8-one

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(1S,4E,7S,10E,12E,14R,15S,16S)-7-[(E,2S,7S,8R,9R,10S,11S)-7,9-dihydroxy-11-methoxy-8,10-dimethyldodec-4-en-2-yl]-15-hydroxy-10,12,14-trimethyl-8,17-dioxabicyclo[14.1.0]heptadeca-4,10,12-trien-9-one

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(1S,4E,7S,10E,12E,14R,15S,16S)-15-hydroxy-10,12,14-trimethyl-7-[(2S,4E,7S,8R,9S,10R,11S)-7,9,11-trihydroxy-8,10-dimethyldodec-4-en-2-yl]-8,17-dioxabicyclo[14.1.0]heptadeca-4,10,12-trien-9-one

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(3E,5E,7R,8R,9E,13E,16S)-16-[(E,2S)-6-[(2S,3S,4R,5S)-4,6-dihydroxy-3,5,6-trimethyloxan-2-yl]hex-4-en-2-yl]-8-hydroxy-3,5,7-trimethyl-1-oxacyclohexadeca-3,5,9,13-tetraen-2-one

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(3Z,5Z,9Z,13Z,15Z)-8-hydroxy-3,5,7-trimethyl-18-(5,7,9-trihydroxy-6,8-dimethyldecan-2-yl)-1-oxacyclooctadeca-3,5,9,13,15-pentaen-2-one

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1

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Akimasa Miyanaga

8

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Tadashi Eguchi

9

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7

Mario Numakura

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author name string

Koichi Kawamura

2

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Takashi Furuya

3

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Hiroto Yamanishi

4

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Atsushi Motegi

5

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Akiko Komatsubara

6

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publication date

8 January 2016

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volume

17

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issue

3

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page(s)

233-238

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Stereoselective synthesis of the cytotoxic macrolide FD-891

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cites work

1 reference

9 March 2024

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RebG- and RebM-catalyzed indolocarbazole diversification

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Cloning and characterization of the biosynthetic gene cluster of 16-membered macrolide antibiotic FD-891: involvement of a dual functional cytochrome P450 monooxygenase catalyzing epoxidation and hydroxylation

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A concise and unified strategy for synthesis of the C1-C18 macrolactone fragments of FD-891, FD-892 and their analogues: formal total synthesis of FD-891.

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9 March 2024

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Stereoselective total synthesis of FD-891

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9 March 2024

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FD-891, a structural analogue of concanamycin A that does not affect vacuolar acidification or perforin activity, yet potently prevents cytotoxic T lymphocyte-mediated cytotoxicity through the blockage of conjugate formation

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9 March 2024

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Biosynthesis of Mupirocin by Pseudomonas fluorescens NCIMB 10586 Involves Parallel Pathways

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Protein measurement with the Folin phenol reagent

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9 March 2024

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S-adenosyl-methionine-dependent methyltransferases: highly versatile enzymes in biocatalysis, biosynthesis and other biotechnological applications.

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Isolation and characterization of new 18-membered macrolides FD-891 and FD-892

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Characterization of FK506 biosynthetic intermediates involved in post-PKS elaboration

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9 March 2024

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The Post-Polyketide Synthase Modification Steps in the Biosynthesis of the Antitumor Agent Ansamitocin by Actinosynnema pretiosum

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9 March 2024

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FK506 maturation involves a cytochrome p450 protein-catalyzed four-electron C-9 oxidation in parallel with a C-31 O-methylation.

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9 March 2024

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Enantioselective total synthesis of FD-891

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Production of Phytotoxins, Concanamycins A and B by Streptomyces spp. Causing Potato Scab.

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9 March 2024

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Structure revision of FD-891, a 16-membered macrolide antibiotic

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9 March 2024

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Structure and mechanism of the rebeccamycin sugar 4'-O-methyltransferase RebM

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9 March 2024

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Parallel pathways for oxidation of 14-membered polyketide macrolactones in Saccharopolyspora erythraea

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9 March 2024

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The cytotoxic macrolide FD-891 induces caspase-8-dependent mitochondrial release of cytochrome c and subsequent apoptosis in human leukemia Jurkat cells

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Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis

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9 March 2024

https://opencitations.net/index/api/v1/references/10.1002/CBIC.201500533

Identifiers

DOI

10.1002/CBIC.201500533

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