Combining Immune Checkpoint Blockade and Tumor-Specific Vaccine for Patients With Incurable Human Papillomavirus 16-Related Cancer: A Phase 2 Clinical Trial (Q59351645)

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English	Combining Immune Checkpoint Blockade and Tumor-Specific Vaccine for Patients With Incurable Human Papillomavirus 16-Related Cancer: A Phase 2 Clinical Trial	article

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25 April 2020

Combining Immune Checkpoint Blockade and Tumor-Specific Vaccine for Patients With Incurable Human Papillomavirus 16-Related Cancer: A Phase 2 Clinical Trial (English)

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25 April 2020

phase II clinical trial

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human papillomavirus 16

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Ignacio I Wistuba

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Ignacio Wistuba

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25 April 2020

Erminia Massarelli

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Erminia Massarelli

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25 April 2020

Chantale Bernatchez

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Chantale Bernatchez

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25 April 2020

Sjoerd H van der Burg

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Sjoerd H van der Burg

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25 April 2020

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William William

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25 April 2020

Faye Johnson

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25 April 2020

Merrill Kies

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25 April 2020

Renata Ferrarotto

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25 April 2020

Ming Guo

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25 April 2020

Lei Feng

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25 April 2020

J Jack Lee

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25 April 2020

Hai Tran

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25 April 2020

Young Uk Kim

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25 April 2020

Cara Haymaker

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25 April 2020

Michael Curran

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25 April 2020

Tomas Zecchini Barrese

14

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25 April 2020

Jaime Rodriguez Canales

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25 April 2020

Lerong Li

17

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25 April 2020

Jing Wang

18

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25 April 2020

Cornelis J Melief

20

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25 April 2020

Bonnie Glisson

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25 April 2020

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1 January 2019

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25 April 2020

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25 April 2020

5

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25 April 2020

1

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25 April 2020

67-73

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25 April 2020

Optimal two-stage designs for phase II clinical trials

1 reference

https://pubmed.ncbi.nlm.nih.gov/30267032

12 December 2020

based on heuristic

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Phase I Immunotherapeutic Trial with Long Peptides Spanning the E6 and E7 Sequences of High-Risk Human Papillomavirus 16 in End-Stage Cervical Cancer Patients Shows Low Toxicity and Robust Immunogenicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30267032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of Tumor-Specific CD4+ and CD8+ T-Cell Immunity in Cervical Cancer Patients by a Human Papillomavirus Type 16 E6 and E7 Long Peptides Vaccine

1 reference

https://pubmed.ncbi.nlm.nih.gov/30267032

12 December 2020

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Superior induction of anti-tumor CTL immunity by extended peptide vaccines involves prolonged, DC-focused antigen presentation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30267032

12 December 2020

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inferred from PubMed ID database lookup

New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)

1 reference

https://pubmed.ncbi.nlm.nih.gov/30267032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia

1 reference

https://pubmed.ncbi.nlm.nih.gov/30267032

12 December 2020

based on heuristic

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Clinical validation of the Cervista HPV HR and 16/18 genotyping tests for use in women with ASC-US cytology

1 reference

https://pubmed.ncbi.nlm.nih.gov/30267032

12 December 2020

based on heuristic

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Immunotherapy against HPV16/18 generates potent TH1 and cytotoxic cellular immune responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/30267032

12 December 2020

based on heuristic

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HPV16 synthetic long peptide (HPV16-SLP) vaccination therapy of patients with advanced or recurrent HPV16-induced gynecological carcinoma, a phase II trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/30267032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dendritic cells process synthetic long peptides better than whole protein, improving antigen presentation and T-cell activation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30267032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/30267032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cervista HPV assays for fine-needle aspiration specimens are a valid option for human papillomavirus testing in patients with oropharyngeal carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30267032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clearance of persistent HPV infection and cervical lesion by therapeutic DNA vaccine in CIN3 patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/30267032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Statistical inference for extended or shortened phase II studies based on Simon's two-stage designs

1 reference

https://pubmed.ncbi.nlm.nih.gov/30267032

12 December 2020

based on heuristic

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Therapeutic cancer vaccines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30267032

12 December 2020

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Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: a randomised, double-blind, placebo-controlled phase 2b tri

1 reference

https://pubmed.ncbi.nlm.nih.gov/30267032

12 December 2020

based on heuristic

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Vaccination against Oncoproteins of HPV16 for Noninvasive Vulvar/Vaginal Lesions: Lesion Clearance Is Related to the Strength of the T-Cell Response.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30267032

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based on heuristic

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Vaccines for established cancer: overcoming the challenges posed by immune evasion

1 reference

https://pubmed.ncbi.nlm.nih.gov/30267032

12 December 2020

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Vaccination during myeloid cell depletion by cancer chemotherapy fosters robust T cell responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/30267032

12 December 2020

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Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): an open-label, multicentre, phase 1b trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/30267032

12 December 2020

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Image Analysis-based Assessment of PD-L1 and Tumor-Associated Immune Cells Density Supports Distinct Intratumoral Microenvironment Groups in Non-small Cell Lung Carcinoma Patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/30267032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumor Activity of Pembrolizumab in Biomarker-Unselected Patients With Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma: Results From the Phase Ib KEYNOTE-012 Expansion Cohort.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30267032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck

1 reference

https://pubmed.ncbi.nlm.nih.gov/30267032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pembrolizumab for Platinum- and Cetuximab-Refractory Head and Neck Cancer: Results From a Single-Arm, Phase II Study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30267032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intratumoral HPV16-specific T-cells constitute a type 1 oriented tumor microenvironment to improve survival in HPV16-driven oropharyngeal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30267032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Programmed Death-Ligand 1 Immunohistochemistry Testing: A Review of Analytical Assays and Clinical Implementation in Non-Small-Cell Lung Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30267032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficacy and safety of pembrolizumab in recurrent/metastatic head and neck squamous cell carcinoma: pooled analyses after long-term follow-up in KEYNOTE-012

1 reference

https://pubmed.ncbi.nlm.nih.gov/30267032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1001/JAMAONCOL.2018.4051

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Europe PubMed Central

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25 April 2020

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25 April 2020

PubMed publication ID

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Europe PubMed Central

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25 April 2020

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