GAB2 is a novel target of 11q amplification in AML/MDS (Q58957431)

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28 January 2020

title

GAB2 is a novel target of 11q amplification in AML/MDS (English)

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28 January 2020

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28 January 2020

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Frank Speleman

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28 January 2020

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Andrea Zatkova

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28 January 2020

author name string

Bruce Poppe

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28 January 2020

Christa Fonatsch

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28 January 2020

Katharina Wimmer

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28 January 2020

Claudia Schoch

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publication date

1 September 2006

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Genes, Chromosomes and Cancer

28 January 2020

published in

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volume

45

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28 January 2020

page(s)

798-807

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28 January 2020

issue

9

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Combined array comparative genomic hybridization and tissue microarray analysis suggest PAK1 at 11q13.5-q14 as a critical oncogene target in ovarian carcinoma

28 January 2020

cites work

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Duplication or amplification of chromosome band 11q23, including the unrearranged MLL gene, is a recurrent abnormality in therapy-related MDS and AML, and is closely related to mutation of the TP53 gene and to previous therapy with alkylating agents

21 January 2018

1 reference

7 January 2021

A role for the scaffolding adapter GAB2 in breast cancer

1 reference

7 January 2021

Molecular basis of 11q23 rearrangements in hematopoietic malignant proliferations.

1 reference

7 January 2021

Transcriptional regulation of AKT activation by E2F.

1 reference

7 January 2021

MLL amplification in acute leukaemia: a United Kingdom Cancer Cytogenetics Group (UKCCG) study

1 reference

7 January 2021

The docking protein Gab2 is overexpressed and estrogen regulated in human breast cancer

1 reference

7 January 2021

Regulation of the Erk2-Elk1 signaling pathway and megakaryocytic differentiation of Bcr-Abl(+) K562 leukemic cells by Gab2

1 reference

7 January 2021

Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation

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7 January 2021

Progestins and androgens increase expression of Spot 14 in T47-D breast tumor cells

1 reference

7 January 2021

Scaffolding protein Gab2 mediates fibroblast transformation by the SEA tyrosine kinase

1 reference

7 January 2021

The application of comparative genomic hybridization as an additional tool in the chromosome analysis of acute myeloid leukemia and myelodysplastic syndromes

1 reference

7 January 2021

Cytogenetic profile of myelodysplastic syndromes with complex karyotypes: an analysis using spectral karyotyping

1 reference

7 January 2021

Analysis of myelodysplastic syndromes with complex karyotypes by high-resolution comparative genomic hybridization and subtelomeric CGH array

1 reference

7 January 2021

MLL amplification in myeloid leukemias: A study of 14 cases with multiple copies of 11q23

1 reference

7 January 2021

Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations.

1 reference

7 January 2021

Spectral karyotyping in patients with acute myeloid leukemia and a complex karyotype shows hidden aberrations, including recurrent overrepresentation of 21q, 11q, and 22q.

1 reference

7 January 2021

The role of Gab family scaffolding adapter proteins in the signal transduction of cytokine and growth factor receptors

1 reference

7 January 2021

Oncogene amplification in transforming myelodysplasia

1 reference

7 January 2021

RTPrimerDB: the real-time PCR primer and probe database

1 reference

7 January 2021

Critical role for hematopoietic cell kinase (Hck)-mediated phosphorylation of Gab1 and Gab2 docking proteins in interleukin 6-induced proliferation and survival of multiple myeloma cells.

1 reference

7 January 2021

Expression analyses identify MLL as a prominent target of 11q23 amplification and support an etiologic role for MLL gain of function in myeloid malignancies

1 reference

7 January 2021

Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases

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7 January 2021

The multiple function of Grb2 associated binder (Gab) adaptor/scaffolding protein in immune cell signaling.

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7 January 2021

Critical role for Gab2 in transformation by BCR/ABL

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7 January 2021

Abnormal dicentric chromosome with co-amplification of sequences from chromosomes 11 and 19: a novel rearrangement in a patient with myelodysplastic syndrome transforming to acute myeloid leukemia

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7 January 2021

Amplification of the MLL gene on double minutes, a homogeneously staining region, and ring chromosomes in five patients with acute myeloid leukemia or myelodysplastic syndrome

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7 January 2021

Amplified, lost, and fused genes in 11q23-25 amplicon in acute myeloid leukemia, an array-CGH study

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7 January 2021

Identification of cytogenetic subclasses and recurring chromosomal aberrations in AML and MDS with complex karyotypes using M-FISH.

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7 January 2021

Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

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7 January 2021

Amplification and overexpression of the IGF2 regulator PLAG1 in hepatoblastoma

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7 January 2021

Distinct sequences on 11q13.5 and 11q23-24 are frequently coamplified with MLL in complexly organized 11q amplicons in AML/MDS patients

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7 January 2021

G-CSF-induced tyrosine phosphorylation of Gab2 is Lyn kinase dependent and associated with enhanced Akt and differentiative, not proliferative, responses

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7 January 2021

Identifiers

DOI

10.1002/GCC.20344

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28 January 2020

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