Mechanistic investigation of the oxidation of hydrazides: implications for the activation of the TB drug isoniazid (Q58867028)

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18 February 2020

title

Mechanistic investigation of the oxidation of hydrazides: implications for the activation of the TB drug isoniazid (English)

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18 February 2020

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1

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18 February 2020

Brian F Yates

3

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18 February 2020

Trevor Lewis

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18 February 2020

Jason Smith

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18 February 2020

author name string

Brendon S Gourlay

2

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18 February 2020

Carl H Schiesser

4

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publication date

1 January 2013

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Organic and Biomolecular Chemistry

18 February 2020

published in

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18 February 2020

volume

11

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18 February 2020

issue

1

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18 February 2020

page(s)

170-176

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Tuberculosis: commentary on a reemergent killer

18 February 2020

cites work

1 reference

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Enzymatic characterization of the target for isoniazid in Mycobacterium tuberculosis

21 January 2018

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inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis

21 January 2018

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Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis

21 January 2018

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Evidence for isoniazid-dependent free radical generation catalyzed by Mycobacterium tuberculosis KatG and the isoniazid-resistant mutant KatG(S315T).

21 January 2018

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Use of site-directed mutagenesis to probe the structure, function and isoniazid activation of the catalase/peroxidase, KatG, from Mycobacterium tuberculosis

21 January 2018

1 reference

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A mechanistic study on the oxidation of hydrazides: application to the tuberculosis drug isoniazid.

21 January 2018

1 reference

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Synthesis, crystal structures, reactivity, and magnetochemistry of a series of binuclear complexes of manganese(II), -(III), and -(IV) of biological relevance. The crystal structure of [L'MnIV(.mu.-O)3MnIVL'](PF6)2.H2O containing an unprecedented sho

21 January 2018

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Evidence for a higher oxidation state of manganese in the reaction of dinuclear manganese complexes with oxidants. Comparison with iron based Gif chemistry

21 January 2018

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Binuclear manganese complexes as catalysts in the selective and efficient oxidation of sulfides to sulfones

21 January 2018

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Acyl radical addition to pyridine: multiorbital interactions

21 January 2018

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Nucleophilic acyl substitution of acyl diimides.

21 January 2018

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Regioselectivity in the addition of vinylmagnesium bromide to heteroarylic ketones: C- versus O-alkylation

21 January 2018

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Biomimetic carbene-catalyzed oxidations of aldehydes using TEMPO.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1039/C2OB26419F

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18 February 2020

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