Functional analyses and molecular modeling of two c-Kit mutations responsible for imatinib secondary resistance in GIST patients (Q58813365)

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29 January 2020

title

Functional analyses and molecular modeling of two c-Kit mutations responsible for imatinib secondary resistance in GIST patients (English)

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29 January 2020

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1

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Sabrina Pricl

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29 January 2020

Tiziana Negri

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29 January 2020

Angela Greco

6

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29 January 2020

Alessandro Gronchi

7

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29 January 2020

Paolo Giovanni Casali

8

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29 January 2020

Maurizio Fermeglia

10

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29 January 2020

Antonino Carbone

11

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29 January 2020

Marco A. Pierotti

12

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29 January 2020

author name string

M S Lagonigro

4

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29 January 2020

F Miselli

5

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29 January 2020

M Ferrone

9

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29 January 2020

S Pilotti

13

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language of work or name

English

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publication date

5 June 2006

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29 January 2020

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29 January 2020

volume

25

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29 January 2020

issue

45

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29 January 2020

page(s)

6140-6146

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1209639

29 January 2020

exact match

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cites work

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Structural and energetic responses to cavity-creating mutations in hydrophobic cores: observation of a buried water molecule and the hydrophilic nature of such hydrophobic cavities

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A missense mutation in KIT kinase domain 1 correlates with imatinib resistance in gastrointestinal stromal tumors

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Biology of gastrointestinal stromal tumors.

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KIT mutations are common in incidental gastrointestinal stromal tumors one centimeter or less in size

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A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules

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Mechanisms of resistance to imatinib mesylate in gastrointestinal stromal tumors and activity of the PKC412 inhibitor against imatinib-resistant mutants

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Response of a protein structure to cavity-creating mutations and its relation to the hydrophobic effect

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Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor

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Structural basis for the autoinhibition and STI-571 inhibition of c-Kit tyrosine kinase

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Structure of a c-kit product complex reveals the basis for kinase transactivation

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Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

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In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants

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T315I-mutated Bcr-Abl in chronic myeloid leukemia and imatinib: insights from a computational study

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Investigating the binding specificity of U1A-RNA by computational mutagenesis

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A new mutation in the KIT ATP pocket causes acquired resistance to imatinib in a gastrointestinal stromal tumor patient

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7 January 2021

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