Improved outcomes in PI3K-pathway-altered metastatic HPV oropharyngeal cancer (Q58760723)

1

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Alec Kacew

2

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Nicole G Chau

3

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Priyanka Shivdasani

4

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Jochen H Lorch

5

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Ravindra Uppaluri

6

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Robert I Haddad

7

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Laura E MacConaill

Frameshift events predict anti-PD-1/L1 response in head and neck cancer.

8

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language of work or name

English

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publication date

6 September 2018

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published in

JCI insight

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volume

3

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issue

17

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cites work

1 reference

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Emerging insights into recurrent and metastatic human papillomavirus-related oropharyngeal squamous cell carcinoma

30 November 2018

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The prognostic impact of human papillomavirus status following treatment failure in oropharyngeal cancer.

30 November 2018

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Validation of OncoPanel: A Targeted Next-Generation Sequencing Assay for the Detection of Somatic Variants in Cancer.

30 November 2018

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Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.

30 November 2018

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Buparlisib and paclitaxel in patients with platinum-pretreated recurrent or metastatic squamous cell carcinoma of the head and neck (BERIL-1): a randomised, double-blind, placebo-controlled phase 2 trial

30 November 2018

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Head and Neck cancers-major changes in the American Joint Committee on cancer eighth edition cancer staging manual

30 November 2018

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E1308: Phase II Trial of Induction Chemotherapy Followed by Reduced-Dose Radiation and Weekly Cetuximab in Patients With HPV-Associated Resectable Squamous Cell Carcinoma of the Oropharynx- ECOG-ACRIN Cancer Research Group

30 November 2018

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Institutional implementation of clinical tumor profiling on an unselected cancer population

30 November 2018

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Detection of Mismatch Repair Deficiency and Microsatellite Instability in Colorectal Adenocarcinoma by Targeted Next-Generation Sequencing.

30 November 2018

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Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck

30 November 2018

1 reference

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Antitumor Activity of Pembrolizumab in Biomarker-Unselected Patients With Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma: Results From the Phase Ib KEYNOTE-012 Expansion Cohort.

30 November 2018

1 reference

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DNA-PKcs plays role in cancer metastasis through regulation of secreted proteins involved in migration and invasion

30 November 2018

1 reference

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Effect of human papillomavirus on patterns of distant metastatic failure in oropharyngeal squamous cell carcinoma treated with chemoradiotherapy.

30 November 2018

1 reference

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Comprehensive genomic characterization of head and neck squamous cell carcinomas

30 November 2018

1 reference

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HPV DNA, E6/E7 mRNA, and p16INK4a detection in head and neck cancers: a systematic review and meta-analysis

30 November 2018

1 reference

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BreaKmer: detection of structural variation in targeted massively parallel sequencing data using kmers

30 November 2018

1 reference

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Randomized phase III trial to test accelerated versus standard fractionation in combination with concurrent cisplatin for head and neck carcinomas in the Radiation Therapy Oncology Group 0129 trial: long-term report of efficacy and toxicity

30 November 2018

1 reference

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Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6171803

Human papillomavirus and overall survival after progression of oropharyngeal squamous cell carcinoma.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6171803

Prognostic significance of human papillomavirus in recurrent or metastatic head and neck cancer: an analysis of Eastern Cooperative Oncology Group trials

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6171803

Distant metastasis in p16-positive oropharyngeal squamous cell carcinoma: a critical analysis of patterns and outcomes

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6171803

Inhibition of Snail1-DNA-PKcs protein-protein interface sensitizes cancer cells and inhibits tumor metastasis

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6171803

Signatures of mutational processes in human cancer

30 November 2018

1 reference

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Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6171803

Natural course of distant metastases following radiotherapy or chemoradiotherapy in HPV-related oropharyngeal cancer

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6171803

Malignant and nonmalignant gene signatures in squamous head and neck cancer

30 November 2018

1 reference

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Prevalence of human papillomavirus in oropharyngeal and nonoropharyngeal head and neck cancer--systematic review and meta-analysis of trends by time and region

30 November 2018

1 reference

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Human Papillomavirus and Rising Oropharyngeal Cancer Incidence in the United States

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6171803

Survival and human papillomavirus in oropharynx cancer in TAX 324: a subset analysis from an international phase III trial.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6171803

Atypical clinical behavior of p16-confirmed HPV-related oropharyngeal squamous cell carcinoma treated with radical radiotherapy

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6171803

Human papillomavirus and survival of patients with oropharyngeal cancer.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6171803

Intensity-modulated radiotherapy in the treatment of oropharyngeal cancer: clinical outcomes and patterns of failure

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6171803

Activation of the PI3-K/AKT pathway and implications for radioresistance mechanisms in head and neck cancer

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6171803

Evidence for a causal association between human papillomavirus and a subset of head and neck cancers

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6171803