Transduction of mechanical and cytoskeletal cues by YAP and TAZ (Q58660991)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22895435%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

title

Transduction of mechanical and cytoskeletal cues by YAP and TAZ (English)

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11 February 2020

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1

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11 February 2020

Sirio Dupont

series ordinal

2

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11 February 2020

author name string

Stefano Piccolo

series ordinal

3

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11 February 2020

publication date

16 August 2012

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Nature Reviews Molecular Cell Biology

11 February 2020

published in

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11 February 2020

volume

13

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11 February 2020

issue

9

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11 February 2020

page(s)

591-600

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https://scigraph.springernature.com/pub.10.1038/nrm3416

11 February 2020

exact match

0 references

cites work

Mechanotransduction gone awry

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Mechanotransduction in development: a growing role for contractility

31 March 2020

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Cytoskeletal control of growth and cell fate switching

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Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase signaling.

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A tense situation: forcing tumour progression

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Mechanotransduction in vascular physiology and atherogenesis

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Growth factors, matrices, and forces combine and control stem cells

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Role of YAP/TAZ in mechanotransduction

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Hippo pathway regulation by cell morphology and stress fibers.

31 March 2020

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Modulating F-actin organization induces organ growth by affecting the Hippo pathway

31 March 2020

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Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila

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Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis

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The hippo signaling pathway in development and cancer

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The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version

31 March 2020

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Hippo signaling: growth control and beyond

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The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells

31 March 2020

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The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass

31 March 2020

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Cell adhesion: integrating cytoskeletal dynamics and cellular tension

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Local force and geometry sensing regulate cell functions

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Mechanisms of mechanical signaling in development and disease

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Integrins and extracellular matrix in mechanotransduction

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Role of cell shape in growth control

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Fibronectin modulation of cell shape and lipogenic gene expression in 3T3-adipocytes

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Engineering cell shape and function

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Geometric control of cell life and death

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Cell shape controls terminal differentiation of human epidermal keratinocytes

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Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment

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Matrix elasticity directs stem cell lineage specification

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Myotubes differentiate optimally on substrates with tissue-like stiffness: pathological implications for soft or stiff microenvironments

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Substrate elasticity regulates skeletal muscle stem cell self-renewal in culture

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Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK-ERK linkage

31 March 2020

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Cell-cycle control by physiological matrix elasticity and in vivo tissue stiffening

31 March 2020

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Mechanisms by which the extracellular matrix and integrin signaling act to regulate the switch between tumor suppression and tumor promotion

31 March 2020

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Of extracellular matrix, scaffolds, and signaling: tissue architecture regulates development, homeostasis, and cancer.

31 March 2020

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Unraveling the microenvironmental influences on the normal mammary gland and breast cancer

31 March 2020

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The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini.

31 March 2020

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Tensional homeostasis and the malignant phenotype

31 March 2020

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Matrix crosslinking forces tumor progression by enhancing integrin signaling

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Emergent patterns of growth controlled by multicellular form and mechanics

31 March 2020

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Emergence of patterned stem cell differentiation within multicellular structures

31 March 2020

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E-cadherin engagement stimulates proliferation via Rac1

31 March 2020

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alpha-Catenin as a tension transducer that induces adherens junction development

31 March 2020

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Mechanical integration of actin and adhesion dynamics in cell migration

31 March 2020

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Is the mechanical activity of epithelial cells controlled by deformations or forces?

31 March 2020

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Extracellular-matrix tethering regulates stem-cell fate

31 March 2020

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Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate.

31 March 2020

1 reference

Linking actin dynamics and gene transcription to drive cellular motile functions

31 March 2020

1 reference

Actin dynamics control SRF activity by regulation of its coactivator MAL

31 March 2020

1 reference

Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions.

31 March 2020

1 reference

Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

31 March 2020

1 reference

Traction forces exerted through N-cadherin contacts.

31 March 2020

1 reference

Upstream regulation of the hippo size control pathway

31 March 2020

1 reference

The Hippo pathway and apico-basal cell polarity

31 March 2020

1 reference

The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal

31 March 2020

1 reference

Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling

31 March 2020

1 reference

Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene

31 March 2020

1 reference

Yap1 acts downstream of α-catenin to control epidermal proliferation

31 March 2020

1 reference

α-catenin is a tumor suppressor that controls cell accumulation by regulating the localization and activity of the transcriptional coactivator Yap1

31 March 2020

1 reference

Collective and single cell behavior in epithelial contact inhibition.

31 March 2020

1 reference

Matrix stiffening sensitizes epithelial cells to EGF and enables the loss of contact inhibition of proliferation

31 March 2020

1 reference

Beta1 integrin-mediated adhesion signalling is essential for epidermal progenitor cell expansion

31 March 2020

1 reference

Relation of protein synthesis and transglutaminase activity to formation of the cross-linked envelope during terminal differentiation of the cultured human epidermal keratinocyte

31 March 2020

1 reference

Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases

31 March 2020

1 reference

Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth

31 March 2020

1 reference

Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin

31 March 2020

1 reference

YAP1 increases organ size and expands undifferentiated progenitor cells

31 March 2020

1 reference

Intercalary regeneration in imaginal wing disk of Drosophila melanogaster

31 March 2020

1 reference

Regulation of organ growth by morphogen gradients

31 March 2020

1 reference

Model for the regulation of size in the wing imaginal disc of Drosophila

31 March 2020

1 reference

Determination of mechanical stress distribution in Drosophila wing discs using photoelasticity

31 March 2020

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On the mechanism of wing size determination in fly development

31 March 2020

1 reference

Dynamic interplay between the collagen scaffold and tumor evolution

31 March 2020

1 reference

RETRACTED: Lysyl oxidase is essential for hypoxia-induced metastasis

31 March 2020

1 reference

Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies

31 March 2020

1 reference

TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway

31 March 2020

1 reference

The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant glioma

31 March 2020

1 reference

TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal

31 March 2020

1 reference

The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway.

31 March 2020

1 reference

The Hippo pathway regulates Wnt/beta-catenin signaling

31 March 2020

1 reference

Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size

31 March 2020

1 reference

Cooperative regulation of growth by Yorkie and Mad through bantam

31 March 2020

1 reference

The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis

31 March 2020

1 reference

hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts

31 March 2020

1 reference

Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway

31 March 2020

1 reference

The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila.

31 March 2020

1 reference

salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines

31 March 2020

1 reference

Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila

31 March 2020

1 reference

The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation

31 March 2020

1 reference

Elucidation of a universal size-control mechanism in Drosophila and mammals

31 March 2020

1 reference

The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP

31 March 2020

1 reference

In vivo analysis of Yorkie phosphorylation sites.

31 March 2020

1 reference

In vivo regulation of Yorkie phosphorylation and localization.

31 March 2020

1 reference

The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway

31 March 2020

1 reference

SCALLOPED interacts with YORKIE, the nuclear effector of the hippo tumor-suppressor pathway in Drosophila

31 March 2020

1 reference

TEAD mediates YAP-dependent gene induction and growth control

31 March 2020

1 reference

TEADs mediate nuclear retention of TAZ to promote oncogenic transformation

31 March 2020

1 reference

Transcription factor choice in the Hippo signaling pathway: homothorax and yorkie regulation of the microRNA bantam in the progenitor domain of the Drosophila eye imaginal disc

31 March 2020

1 reference

The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control

31 March 2020

1 reference

TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition

31 March 2020

1 reference

Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance

31 March 2020

1 reference

The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis

31 March 2020

1 reference

Kibra is a regulator of the Salvador/Warts/Hippo signaling network

31 March 2020

1 reference

Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded

31 March 2020

1 reference

The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals

31 March 2020

1 reference

Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms.

31 March 2020

1 reference

Tumor suppression by cell competition through regulation of the Hippo pathway

31 March 2020

1 reference

Loss of the Drosophila cell polarity regulator Scribbled promotes epithelial tissue overgrowth and cooperation with oncogenic Ras-Raf through impaired Hippo pathway signaling

31 March 2020

1 reference

Regulation of Hippo signaling by Jun kinase signaling during compensatory cell proliferation and regeneration, and in neoplastic tumors.

31 March 2020

1 reference

Polarity regulators and the control of epithelial architecture, cell migration, and tumorigenesis.

31 March 2020

1 reference

Novel insights into epithelial polarity proteins in Drosophila

31 March 2020

1 reference

Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded

31 March 2020

1 reference

The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded

31 March 2020

1 reference

The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila

31 March 2020

1 reference

Hippo pathway-dependent and -independent roles of RASSF6.

31 March 2020

1 reference

The Drosophila RASSF homolog antagonizes the hippo pathway

31 March 2020

1 reference

Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling

31 March 2020

1 reference

Deletion of beta 1 integrins in mice results in inner cell mass failure and peri-implantation lethality

31 March 2020

1 reference

Disruption of the talin gene arrests mouse development at the gastrulation stage

31 March 2020

1 reference

E-cadherin null mutant embryos fail to form a trophectoderm epithelium

31 March 2020

1 reference

Roles for laminin in embryogenesis: exencephaly, syndactyly, and placentopathy in mice lacking the laminin alpha5 chain

31 March 2020

1 reference

Tensile forces govern germ-layer organization in zebrafish.

31 March 2020

1 reference

Epithelial machines that shape the embryo

31 March 2020

1 reference

A mechanoresponsive cadherin-keratin complex directs polarized protrusive behavior and collective cell migration

31 March 2020

1 reference

Relaxation-expansion model for self-driven retinal morphogenesis: a hypothesis from the perspective of biosystems dynamics at the multi-cellular level

31 March 2020

1 reference

Mechanochemical control of mesenchymal condensation and embryonic tooth organ formation

31 March 2020

1 reference

The role of mechanical forces in the torsional component of cardiac looping

31 March 2020

1 reference

Intracardiac fluid forces are an essential epigenetic factor for embryonic cardiogenesis

31 March 2020

1 reference

Biomechanical forces promote embryonic haematopoiesis

31 March 2020

1 reference

Hematopoietic stem cell development is dependent on blood flow.

31 March 2020

1 reference

Mechanical tugging force regulates the size of cell-cell junctions

31 March 2020

1 reference

How we are shaped: the biomechanics of gastrulation

31 March 2020

1 reference

Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22895435

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Cell-extracellular matrix interactions in normal and diseased skin

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22895435

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRM3416

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22895435%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

1 reference